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  • 1
    Electronic Resource
    Electronic Resource
    Quality assurance of monoclonal products: Virologic and molecular biologic considerations (1988)
    Springer
    Journal of industrial microbiology and biotechnology 3 (1988), S. 157-165 
    Details
    ISSN: 1476-5535
    Keywords: Code of Federal Regulations ; DNA ; Factor 8 ; Food and Drug Administration ; Human immunodeficiency virus ; Infectious bovine rhinotracheitis virus ; Monoclonal antibody ; Polynucleotide ; Safety test ; Sindbis virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The FDA has set limits concerning the viral and molecular contamination of monoclonal antibody products intended for human use. Industry has an obligation to be as familiar with these limits as it has been with federal requirements pertaining to pyrogens and bacteria. The assessment of risk from polynucleotides, based on molecular biologic and existing technical limitations, is discssed, as is the strategy of validating the purification of monoclonal antibodies of viral contaminants in terms of an indicator organism concept.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01569522
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence that the methylation inhibitor cycloleucine causes accumulation of a discrete ribosomal RNA precursor in hamster mitochondria (1986)
    Springer
    Molecular biology reports 11 (1986), S. 51-55 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A novel RNA fraction, ‘Cy RNA,’ that accumulates in mitochondria when hamster cells are treated with the methylation inhibitor cycloleucine, has been characterized by high resolution acrylamide gel electrophoresis and DNA-RNA hybridization. Cy RNA ran in gels as a discrete band, with an apparent chain length of 2 600. It hybridized specifically to restriction fragments containing genes for the mitochondrial ribosomal RNAs. We infer that Cy RNA is a discrete polycistronic ribosomal RNA precursor transcript, whose processing is dependent on normal methylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417596
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mass spectrometry of modified nucleic acid bases and nucleosides: 1 - 3-deazauracil and 3-deazauridine (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1983), S. 34-45 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectral fragmentations of 3-deazauracil, 3-deazauridine and selected derivatives are described. Fragmnetations give rise to ions diagnostic of specific positions in the base and/or sugar moieties. Ion structure are rationalized based on isotopic labeling, metastable ion analysis and high resolution data. The spectrum of 3-deazauracil resembles that of cytosine more closely than uracil. The spectrum of 3-deazauridine is almost identical to that of 1-β-D-arabinofuranosyl cytosine, closely resembles that of cytidine and differs significantly from uridine. The formation of a strong b+41 ion in the spectrum of 3-deazauridine raises questions on the utility of the b+41 ions in assigning a cytidine structure to an unknown nucleoside based solely on this ion.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200100108
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    Paper (German National Licenses)
    Fulltext
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