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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of Immunoglobulin Heavy Chain Rearrangements Between Peripheral and Glandular B Cells in a Patient with Primary Sjögren's Syndrome (2003)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 57 (2003), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Myoepithelial sialadenitis (MESA) of the major salivary glands is a characteristic feature of primary Sjögren's syndrome (pSS). To delineate systemic and organ-specific influences on B cells in a patient with pSS and benign MESA, individual B cells were simultaneously obtained from the peripheral blood and inflamed parotid gland. Immunoglobulin variable heavy chain (VH) rearrangements in single sorted CD19+ B cells were subsequently amplified, sequenced and analysed. Despite the presence of two clonal expansions using VH1-08 and VH2-70 segments, respectively, the majority of glandular B cells were polyclonal, resembling the VH gene usage and mutational pattern of the corresponding blood population. However, striking differences were observed in the proportion of cells expressing mutated VH rearrangements (blood, 28.9% versus parotid, 80.4%; P 〈 0.0001). Moreover, the glandular productive VH rearrangements differed significantly from their blood counterparts by a higher mutational frequency (P 〈 0.0001), shorter CDR3 lengths (P = 0.001) and a less frequent usage of JH6 (P = 0.0292), indicating an accumulation of memory B cells in the inflamed parotid. Thus, both preferential influx/homing of memory B cells and local proliferation may contribute to the pattern of benign MESA in pSS. Notably, one of the glandular clonal rearrangements (using VH1-08) was also detected in the patient's peripheral repertoire.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2003.01226.x
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  • 2
    Electronic Resource
    Electronic Resource
    Reversible electrochemical insertion of anions in poly-p-phenylene from aqueous electrolytes
    Amsterdam : Elsevier
    Journal of Electroanalytical Chemistry 172 (1984), S. 281-288 
    Details
    ISSN: 0022-0728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-0728(84)80192-8
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  • 3
    Electronic Resource
    Electronic Resource
    Anodic overoxidation of poly-p-phenylene in aqueous electrolytes
    Amsterdam : Elsevier
    Journal of Electroanalytical Chemistry 216 (1987), S. 157-168 
    Details
    ISSN: 0022-0728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-0728(87)80204-8
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  • 4
    Electronic Resource
    Electronic Resource
    Subclinical activation of latent cytomegalovirus (CMV) infection and anti-CMV immune response in patients with atopic dermatitis (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Microbiological infections are considered to be of pathophysiological importance in atopic dermatitis (AD). As yet, no information is available regarding cytomegalovirus (CMV) infection in this disease. This, however, is of interest because of the high prevalence of latent infections in the general population, the frequent reactivation in inflammatory diseases, and the immunomodulating capacity of CMV. Objectives To investigate the prevalence of latent CMV infection, the frequency of active CMV infection, and the immune response to CMV in patients with moderate to severe AD. Methods To detect active infection we analysed CMV antigen expression by peripheral blood mononuclear cells (PBMC) from 27 patients with moderate to severe AD in comparison with 53 healthy volunteers. We used three monoclonal antibodies recognizing different CMV-encoded antigens and immunocytological staining (alkaline phosphatase–antialkaline phosphatase technique). Results Patients with AD had a higher mean frequency of CMV-positive PBMC: 2·25 per 10 000 vs. 0·74 per 10 000 in controls (P = 0·001) as well as a higher incidence of CMV antigenaemia: 29·6% vs. 7·5% (P 〈 0·01). Seropositivity for anti-CMV IgG antibodies indicated subclinical activation of latent infection. Remarkably, a clearance of CMV antigenaemia was observed during anti-eczematous treatment. Significantly higher plasma levels of tumour necrosis factor-α, which is involved in CMV reactivation, and interleukin-12, which is crucial for an antiviral cellular immune response, were observed in AD patients in comparison with healthy volunteers. Furthermore, a significantly enhanced frequency of circulating activated HLA-DR+ T cells especially in CMV-seropositive AD patients (19·3% vs. 13·5% in seronegative AD patients vs. 10·2% in controls) suggested that the active CMV infection triggers a cellular immune response. This was also supported by a high frequency of CMV-specific interferon-γ-producing T cells in CMV-seropositive patients with AD. Conclusions Our data suggest that active, subclinical CMV infection is more frequent in patients with moderate to severe AD and may have immunopathophysiological relevance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05263.x
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  • 5
    Electronic Resource
    Electronic Resource
    Diagnostik und Therapie der hämorrhagischen Diathese in der perioperativen Situation (1999)
    Springer
    Gefässchirurgie 4 (1999), S. 5-12 
    Details
    ISSN: 1434-3932
    Keywords: Schlüsselwörter Blutungsneigung ; Hämorrhagische Diathese ; Erworbene und angeborene Thrombopathien ; Plasmatische Gerinnungstörungen ; DDAVP ; Key words Bleeding tendency ; Hemorrhagic diathesis ; Acquired and congenital qualitative platelet disorders ; Blood coagulation disorders ; Deamino-d-arginine vasopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract In surgical procedures associated with high blood loss, such as vascular and cardiac operations, differential diagnosis and therapy of perioperative hemorrhage are of special importance. Preoperative screening for patients at high risk of bleeding and in particular for those with qualitative platelet disorders [drug-induced platelet disorders (in particular ASS), von Willebrand's disease and other congenital platelet disorders] is effective in minimizing blood loss. Bleeding in acute medical emergencies or during emergency operations may require treatment without specific investigations being performed in advance. Therefore, simple schemes are essential for the rapid management of acute hemostatic problems. The aim of this paper was to address the diagnostic and therapy of hemorrhagic diathesis focusing mainly on diagnosis and therapy of hemorrhagic diathesis due to blood platelet disorders and blood coagulation disorders and preoperative identification of patients at increased risk of bleeding.
    Notes: Zusammenfassung Die Differentialdiagnostik und Therapie von perioperativen Blutungen besitzt in der Gefäß- und Kardiochirurgie bei Eingriffen mit hohen Blutverlusten einen besonderen Stellenwert. So ist es sinnvoll, Patienten mit einem erhöhten Blutungsrisiko bereits präoperativ zu erfassen und adäquat vorzubereiten. Insbesondere die präoperative Erfassung von Thrombopathien [medikamenteninduzierte Thrombopathien (insbesondere durch ASS), von-Willebrand-Jürgens-Syndrom, andere angeborene Thrombopathien] ist bei der Minimierung von Blutverlusten effektiv. Nicht elektive Situationen (Blutung bei Notoperationen, Akutpatienten) müssen oft ohne gezielte hämostaseologische Diagnostik rational therapiert werden. Einfache Schemata sind für ein schnelles Handeln unabdingbar. In dieser Arbeit soll versucht werden, Hinweise zu Diagnostik und Therapie der hämorrhagischen Diathese mit den Schwerpunkten: Diagnostik und Therapie der thrombozytär bedingten hämorrhagischen Diathese und Diagnostik und Therapie der plasmatisch bedingten hämorrhagischen Diathese aus hämostaseologisch-transfusionsmedizinischer Sicht zu vermitteln. Ein für den Routinebetrieb auf chirurgischen Stationen anwendbares Schema zur präoperativen Erfassung von Patienten mit erhöhtem Blutungsrisiko sowie erste Erfahrungen damit werden vorgestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010539
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  • 6
    Electronic Resource
    Electronic Resource
    Preparation of a pure autologous biodegradable fibrin matrix for tissue engineering (2000)
    Springer
    Medical & biological engineering & computing 38 (2000), S. 686-689 
    Details
    ISSN: 1741-0444
    Keywords: Tissue engineering ; Autologous fibrinogen ; Thrombin ; Matrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Parallel to the growing role of tissue engineering, the need for cell embedding materials, which allow cells to stabilise in a three-dimensional distribution, has increased. Although several substances have been tested, fibrin is thus far the only one that permits the clinical application of cultured tissue. To date, can cause severe immunological side effects. The objective of this study was to explore the practicability of obtaining autologous thrombin from a single patient in an adequate concentration and amount. Fibrinogen was cryoprecipitated from 200 ml of freshly-frozen plasma. Thrombin was isolated from the supernatant through ionexchange chromatography. The thrombin was first bound to Sephadex A-50 and then eluated using 2ml of a salt buffer (2.0M NaCl in 0.015M trisodiumcitrate, pH 7.0). The activity of the thrombin (51 NIH ml−1 to 414 NIH ml−1) reached levels comparable to those in commercially available fibrin glues (4–500 NIH ml−1). The study has shown that it is possible to obtain a sufficient amount of autologous thrombin from a single donor to create a fibrin matrix of high efficiency without the risk of immunological and infectious side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02344876
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  • 7
    Electronic Resource
    Electronic Resource
    Remarks on summability of series formed from deviation probabilities of sums of independent identically distributed random variables (1996)
    Springer
    Ukrainian mathematical journal 48 (1996), S. 569-572 
    Details
    ISSN: 1573-9376
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Description / Table of Contents: Abstract Одержано результати, що уточнюють недавню роботу О. І. Кльосова (1993) про зв'язок між збіжністю $$\sum\nolimits_{n = 1}^\infty {\tau _n P(|S_n | \geqslant \varepsilon n^\alpha )} $$ для всіх ɛ〉0 і збіжністю $$\sum\nolimits_{n = 1}^\infty {n\tau _n P(|X_1 | \geqslant \varepsilon n^\alpha )} $$ також для всіх ɛ〉0.
    Notes: Abstract We make some remarks leading to a refinement of the recent work of O. I. Klesov (1993) on the connection between the convergence of $$\sum\nolimits_{n = 1}^\infty {\tau _n P(|S_n | \geqslant \varepsilon n^\alpha )} $$ for every ɛ〉0 and that of $$\sum\nolimits_{n = 1}^\infty {n\tau _n P(|X_1 | \geqslant \varepsilon n^\alpha )} $$ again for every ɛ〉0.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02390624
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  • 8
    Electronic Resource
    Electronic Resource
    Change of mechanical properties of hardened steel 45 in the process of tempering (1985)
    Springer
    Metal science and heat treatment 27 (1985), S. 661-662 
    Details
    ISSN: 1573-8973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00701060
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  • 9
    Electronic Resource
    Electronic Resource
    54. Neue Internationale Standard-Zustandsgleichung für Wasser zum allgemeinen und wissenschaftlichen Gebrauch (1996)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 68 (1996), S. 1100-1101 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330680956
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