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  • 1
    ISSN: 1432-0533
    Schlagwort(e): Labelled Penicillin ; Quantitative Radioautography ; Epileptogenous Foci ; Blood Brain Barrier
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The intracerebral diffusion of penicillin, intravenously injected to stimulate epileptogenic foci in the cat, has been studied by means of radioautography. Two facts are pointed out: First, penicillin is located in the lesion and its vicinity but nowhere else in the brain. The antibiotic seems to be stored in the focus from which it will spread into the nervous tissue. Second, the spread of penicillin is slightly increased when the time of contact of penicillin with the living brain is longer. Thus, the focus and its surroundings are the only regions concerned by penicillinic activation.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 33 (1975), S. 143-152 
    ISSN: 1432-0533
    Schlagwort(e): Electron microscopy ; Experimental epilepsy ; Oedema
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Three different types of lesions have been studied in the cortex of the cat, by means of electroencephalography and electron microscopy. These three types of lesions can be listed in order of increasing magnitude according to their capacity to induce abnormal electrical activity: 1. incision of the cortex gives paroxymal activity, 2. intracortical insertion of a resin pellet generates weak epileptic activity, 3. intracortical insertion of a cobalt resin pellet produces epileptic activity. A parallel can be drawn between electrophysiological and anatomical data: there seems to be a quantitative relationship between the degree of epileptic activity and the extent of perilesional tissue. Furthermore, in this perilesional tissue, oedema is observed, the intensity of which varies according to the type of lesion. Thus, the epileptic activity of a lesion seems to be proportional not only to the volume of the perilesional tissue but also to the development of the oedema.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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