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  • 1
    Electronic Resource
    Electronic Resource
    Electron microscopic study of metachromatic leucodystrophy (1969)
    Springer
    Acta neuropathologica 13 (1969), S. 149-156 
    Details
    ISSN: 1432-0533
    Keywords: Electron Microscopy ; Leucodystrophy, Metachromatic ; Enzyme Histochemistry, Electronmicroscopical ; Lysosomes ; Neurochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Dans la leucodystrophie métachromatique, les lipides anormaux s'accumulent dans les lysosomes des cellules gliales et des phagocytes. Les inclusions lipidiques les moins organisées sont les plus riches en phosphatases acides. Celles dont l'ultrastructure est prismatique ont une activité enzymatique très faible et semblent plus proches de corps résiduels que de lysosomes actifs. Il semble que l'absence d'arylsulfatase lysosomiale induise la persistance des sulfatides accumulés dans les lysosomes alors que les autres lipides provenant de la dégénérescence myélinique, seraient normalement catabolisés. Un remaniement progressif de l'ultrastructure du contenu des lysosomes en est la conséquence.
    Notes: Summary In metachromatic leucodystrophy abnormal lipids are stored within the lysosomes of the glial cells and phagocytes. The lipid inclusions which are the less structured are the richest in acid phosphatases. Those of which the ultrastructure is prismatic show a very low enzymatic activity and are more similar to residual bodies than to active lysosomes. It appears that the lack in lysosomal arylsulfatase leads to an accumulation of the sulfatide moiety of the stored lipids while the other lipids originating from the myelin breakdown, would be normally catabolized. This leads to a progressive transformation of the ultrastructure of the lysosome contents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687027
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  • 2
    Electronic Resource
    Electronic Resource
    Localization of transforming growth factor-β 1 precursor and latent TGF-β 1 binding protein in colorectal adenomas (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 1741-1748 
    Details
    ISSN: 1573-2568
    Keywords: transforming growth factor-β 1 ; latent TGF-β binding protein ; colorectal adenoma ; colorectal tumorigenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Transforming growth factor-β 1 (TGF-β 1) is a multifunctional cytokine and is thought to be involved in colorectal tumorigenesis as a regulator of cell growth and differentiation. This role is mainly supported byin vitro studies while its rolein vivo remains unclear. The aim of the present study was to investigate whether the TGF-β 1 precursor (β 1-LAP) and the latent TGF-β 1 binding protein (LTBP) are expressed in colorectal adenomas, the presumed precursors of most of colorectal adenocarcinomas. TGF-β 1 precursor and LTBP were examined in 35 adenomas and 10 normal colonic mucosa specimens by immunohistochemistry, using specific polyclonal antibodies. In normal colonic mucosa,β 1-LAP was moderately expressed in epithelial crypt cells and in the stromal cells in the lamina propria. In adenomas,β 1-LAP was localized in epithelial cells with an heterogeneous pattern and was also present in stromal cells around the adenomatous glands. LTBP was not detected in epithelial cells but was observed in stromal cells and in the extracellular matrix (ECM).β 1-LAP expression in epithelial cells did not correlate with the grade of dysplasia, while LTBP localized in stromal cells and ECM appeared to be closely associated with areas of higher grade of dysplasia. This study is the first demonstration of bothβ 1-LAP and LTBP in colorectal adenomas with different dysplasia grades. Our results suggest that TGF-β 1 might be involved in the mechanisms controllingin vivo colorectal tumorigenesis and support a role for the stromal-associated TGF-β 1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088739
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  • 3
    Electronic Resource
    Electronic Resource
    Mini-muduction: A new mode of gene transfer mediated by mini-Mu (1979)
    Springer
    Molecular genetics and genomics 176 (1979), S. 191-197 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We compared the transducing properties of Mucts62 and Mucts62/mini-Mu lysates, using Mu immune and non immune Rec+ and recA recipient strains. The Mu/mini-Mu lysates transduced all bacterial markers tested 10 times more efficiently than the Mucts62 lysates in Rec+ recipients. Most of the transductants obtained after infection with the Mu/mini-Mu lysates result from the substitution of the mutated gene of the recipient by the wild type allele from the donor, most probably carried on the gigantic variable end linked to the mini-Mu genome. Moreover the Mu/mini-Mu lysates gave a new type of Rec-independent transduction that we called mini-muduction. Mini-muduction requires the activity of Mu gene A and provides transductants which carry the transduced marker surrounded by two mini-Mu genomes similarly oriented, and inserted at random location in the recipient chromosome. The mini-Mu/transduced DNA/mini-Mu structures are able to transpose spontaneously, for instance into a transmissible plasmid, in the presence of Mu gene A product.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273213
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  • 4
    Electronic Resource
    Electronic Resource
    Epithelial and neuronal calbindin in avian intestine An immunohistochemical study (1988)
    Springer
    Cell & tissue research 251 (1988), S. 611-620 
    Details
    ISSN: 1432-0878
    Keywords: Calbindin ; Intestinal innervation ; Intestinal endocrine cells ; Calcium-binding protein ; Domestic fowl ; Japanese quail ; Mallard
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary It is well known that calbindin immunoreactivity is highly concentrated in the duodenal absorptive cells of young birds. We have shown that in the adult intestine of three avian species, calbindin content is much more variable. In addition to absorptive cells, we have detected throughout the gut of both sexes of the domestic fowl and in the large intestine of the Japanese quail a second type of calbindin-positive epithelial cell which has the shape of a typical endocrine cell. These cells were particularly abundant in the large intestine, in contrast to the usual distribution of endocrine cells along the gut. Calbindin was also detected in the nervous system of the intestine. Calbindinpositive nerve fibres were rare in the duodenum and ileum, numerous in plexuses and nerve processes in both muscular layers and lamina propria of the large intestine in domestic fowl and Japanese quail. In the mallard, nerve fibres were rarely calbindin positive while definitively positive for VIP. Calbindin of the peripheral nervous system of the domestic fowl and Japanese quail comigrates with the duodenal calbindin (27000 dalton) in SDS gel electrophoresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214010
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    Paper (German National Licenses)
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