ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
2-Alkoxy-5-chloromethy1-1,3,4-thiadiazoles are prepared by ring closure of 3-chloroacetyl-thiocarbazic acid O-alkyl esters with concentrated sulfuric acid, 2-alkylthio-5-chloro-methy1-1,3,4-thiadiazoles directly from dithiocarbazic acid alkylesters with chloroacetylchloride in benzene in a one step synthesis omitting the 3-chloroacetyl-derivatives and 2-alkyl-5-chloro-methy1-1,3,4-oxadiazoles from 1-chloroacetyl-2-acyl-hydrazines with POCl3. These three types of chloromethyl heterocycles easily react with salts of thio- and dithiophosphoric acids to form the corresponding O,O-dialkyl-S-[(2-alkoxy- and 2-alkylthio-1,3,4-thiadiazol-5-yl)-methyl]- and -S-[(2-alky1-1,3,4-oxadiazol-5-yl)-methyl]-thio- and -dithiophosphates.
Additional Material:
7 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19720550616
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