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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Numerische Mathematik 45 (1984), S. 219-225 
    ISSN: 0945-3245
    Keywords: AMS(MOS): 65H10 ; CR: G1.8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary We study monotone iterative methods for the numerical solution of a class of nonlinear elliptic boundary value problems by applying a theorem of Ortega and Rheinboldt. This generalizes the work of earlier authors to the case of nonlinear perturbations of linear problems with a nontrivial kernel.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 6 (1982), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Alpha-I-antitrypsin immunoreactivity was demonstrated by immunofluorescence in epithelial cells of the normal human small intestine. Its presence was also confirmed in biopsies of patients with Crohn's disease. Specific fluorescence was observed in only four out of 14 adult patients with coeliac disease. These results implicate the human small intestinal epithelium as a possible source of alpha-I-antitrypsin. The absence of positive cells may have implications in the aetiology of coeliac disease.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 6 (1982), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Alpha-1-antitrypsin (AAT) was demonstrated in tumour cells in three out of five cases of gastric carcinoma showing the histological characteristics of carcinoid tumour. It was also detected in normal stomach mucosa, but was not found in 10 cases of adenocarcinoma of intestinal or mucous cell type. The AAT-positive tumour cells were argyrophilic, PAS-positive and were negative for pancreatic and gastric hormones. These findings suggest a possible malignant proliferation of alpha-1-antitrypsin-containing cells in the stomach.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 5 (1981), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The incidental finding of orcein positive granules, indicating copper associated protein, in alpha-1-antitrypsin (AAT) positive liver biopsies stimulated a histochemical search for evidence of copper and copper-binding protein in a series of 46 liver biopsies with histological evidence of AAT accumulation. Hepatic accumulation of copper and copper-binding protein occurred in all 19 cirrhotics (100%) and in 14 out of 27 non-cirrhotic livers (51.85%). The overall percentage was 71.73%. AAT and copper deposits coexisted in the same periportal hepatocytes. AAT globules showed positive reactivity both to rhodanine and orcein stains. The severity of chronic liver damage correlated with increasing amounts of copper deposition. It is suggested that in AAT storage, not only is the metabolism of this substance disturbed, but also that of proteins involved in copper metabolism and excretion, resulting in copper accumulation within hepatocytes.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 492 (1987), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 187 (1978), S. 69-77 
    ISSN: 1432-0878
    Keywords: Pancreas (Human) ; Islet cells ; Alpha-1-antitrypsin ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Alpha-1-antitrypsin was demonstrated both by immunofluorescence and immunoperoxidase techniques in the peripheral islet cells of 15 normal human pancreases, processed freshly and after embedding in paraffin. Normal human liver obtained from the same patients was negative. The immunohistochemical reactions were stronger in frozen sections than in paraffin material. However, immunoperoxidase staining on paraffin sections permitted a more precise localization of positive cells. The specificity of the immunohistochemical reactions was confirmed by applying various control tests including absorption of the specific antisera with purified alpha-1-antitrypsin, inhibition and blocking tests. Further examination of pancreatic tissue for the presence of various immunoglobulins, alpha-1-lipoproteins, alpha-1-acid glycoproteins and ceruloplasmin were negative. These findings suggest that the pancreatic islets may be an extra source of alpha-1-antitrypsin.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 185 (1977), S. 63-68 
    ISSN: 1432-0878
    Keywords: Pancreas (Human) ; Islet cells ; Alpha-1-antitrypsin ; Immunofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Alpha-1-antitrypsin immunoreactivity was demonstrated by immunofluorescence technique in the peripheral islet cells of all ten normal adult human pancreata examined; normal adult human liver was negative. The specificity of the reactions was confirmed by applying various control tests including absorption of the specific antisera with purified alpha-1-antitryspin, inhibition and blocking tests and by ensuring the monospecificity of the antisera used. The findings suggest that the pancreatic islet may be an additional source of alpha-1-antitryspin.
    Type of Medium: Electronic Resource
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