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  • 1
    Electronic Resource
    Electronic Resource
    Radiotherapy with a Radiolabeled Somatostatin Analogue, [111In-DTPA-d-Phe1]-Octreotide (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 733 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb17300.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Relationships between the lung-heart ratio assessed from post-exercise thallium-201 myocardial tomograms, myocardial ischemia and the extent of coronary artery disease (1990)
    Springer
    The international journal of cardiovascular imaging 6 (1990), S. 135-141 
    Details
    ISSN: 1573-0743
    Keywords: lung-heart ratio ; thallium-201 scintigraphy ; myocardial ischemia ; revascularisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Uptake of thallium (Tl)-201 in the lungs has been proposed as a measure of left ventricular dysfunction. In this study we were interested in pursuing two goals: 1) to assess possible relationships between the post-exercise Tl-201 lung-heart (LH-) ratio determined from the anterior view during SPECT-acquisition, myocardial ischemia and the extent of coronary artery disease; and 2) to explore the effects of coronary revascularisation procedures on the LH-ratio. The study group consisted of 145 patients with early and late postexercise Tl-201 tomograms, including 32 PTCA-patients with pre- and post-PTCA studies and 20 patients who underwent coronary artery bypass surgery (CABG) with corresponding pre- and post-CABG studies. Ischemia was defined as evoked angina during the exercise test in combination with ≥1 mm horizontal or downsloping ST-depression on the ECG. The severity of coronary obstructions was assessed from coronary angiograms with a PC-based digital caliper technique; a stenosis was defined to be significant when its severity exceeded 50% diameter stenosis. The LH-ratio was defined by the ratio of the mean pulmonary counts and the mean myocardial counts assessed from corresponding regions of interest (ROI's) positioned over the left lung and the heart, respectively in the anterior view of a tomographic data acquisition procedure. Our results made clear that the LH-ratio was not significantly different between patients with and without ischemia during exercise, and between patients with single vs. multiple vessel disease. However, the interventions had a significant effect of the LH-ratio: LH-ratio mean ± s.d. Pre-intervention Post-intervention p-value PTCA 0.33 ± 0.10 0.28 ± 0.08 〈 0.01 CABG 0.34 ± 0.11 0.29 ± 0.07 〈 0.01 In conclusion, the lung-heart ratio assessed from post-exercise Tl-201 tomograms is poorly correlated with myocardial ischemia and is not useful for the diagnosis of multiple CAD. However, the LH-ratio may be a useful complementary measurement in the serial assessment of patients undergoing revascularisation procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02398896
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative study of three different approaches on the estimation of the lung-heart ratio in thallium 201 scintigrams in relation to the extent of coronary artery disease and left ventricular function (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 252-258 
    Details
    ISSN: 1619-7089
    Keywords: Thallium 201 scintigram ; Lung-heart uptake ; Coronary artery disease ; Left ventricular function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Uptake of thallium 201 (201Tl) in the lungs has been proposed as a measure of left ventricular dysfunction with exercise. To study this hypothesis, we compared the lung/-heart (LH) ratio assessed from anterior planar images (ANT-P), from anterior images obtained during single photon emission tomography (SPET) acquisition (ANT-T) and from short-axis tomographic cross-sections (CS) in early post-exercise thallium 201 scintigrams. The study population consisted of 54 prepercutaneous transluminal coronary angioplasty (PTCA) studies (82% with single-vessel disease), 50 post-PTCA studies, 33 pre-coronary artery bypass surgery (CABG) studies (71 % with three-vessel disease), 30 post-CABG studies and 30 patients with a left ventricular dysfunction (LVD) due to an acute myocardial infarction; 18 individuals with a low likelihood of coronary artery disease (CAD) served as a control group. The results demonstrated that, on average, the LH ratios obtained from ANT-P and ANT-T were not significantly different for all study groups; these ratios increased significantly with ischaemia and with LVD relative to non-ischaemic situations. However, the LH ratios in CS did not show a relation with ischaemia nor with LVD and differed significantly from the LH-ratios assessed from the anterior approaches. Each of the three approaches (ANT-P, ANT-T, CS) was characterized by large overlaps of LH ratios for the different study groups. In conclusion, the LH ratio should be determined from ANT-P or ANT-T projection images, not CS. However, due to large overlaps in the measurement data, it is not a clinically useful parameter for the detection of CAD or LVD in the individual patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186649
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  • 4
    Electronic Resource
    Electronic Resource
    Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 716-731 
    Details
    ISSN: 1619-7089
    Keywords: Somatostatin ; Octreotide ; Tumour targeting ; Receptor imaging ; Apudoma ; Lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Various tumours, classically specified as either neuroendocrine or non-neuroendocrine, contain high numbers of somatostatin receptors, which enable in vivo localization of the primary tumour and its metastases by scintigraphy with the radiolabelled somatostatin analogue octreotide. In addition granulomas and autoimmune processes can be visualized because of local accumulation of somatostatin receptor-positive activated mononuclear leucocytes. In many instances a positive scintigram predicts a favourable response to treatment with octreotide. It is tempting to speculate that octreotide labelled with an appropriate radionuclide might be used in cancer therapy. The successful application of radiolabelled octreotide in scintigraphy indicates the possible usefulness of other radiolabelled peptides, either native peptides or derivatives of these, in, for example, nuclear oncology. The small size of these peptides, e.g. bombesin and substance P, is of the utmost importance for a relatively fast blood clearance, thus leading to low background radioactivity. In this way peptides are powerful alternatives to (fragments of) monoclonal antibodies, the application of which to scintigraphic localization of specific cell surface antigen-bearing tumours is plagued by slow blood clearance and, hence, high background levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181765
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison of iodine-123 epidepride and iodine-123 IBZM for dopamine D2 receptor imaging in clinically non-functioning pituitary macroadenomas and macroprolactinomas (1999)
    Springer
    European journal of nuclear medicine 26 (1999), S. 46-50 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Pituitary ; Single-photon emission tomography ; Dopamine receptors - Iodine-123 epidepride ; Iodine-123 IBZM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We compared pituitary iodine-123 epide- pride single-photon emission tomography (SPET) and 123I-IBZM SPET for the in vivo imaging of dopamine D2 receptors in 15 patients with clinically non-functioning pituitary adenomas. Four patients with dopamine agonist-sensitive macroprolactinomas were studied as positive controls. The uptake of radioactivity in the pituitary was established using a visual scoring system and an uptake index calculated by dividing the average count rates in the pituitary area by the average count rates in the cerebellum. All four macroprolactinomas showed specific binding of 123I-epidepride, but only one showed specific binding of 123I-IBZM. Specific binding of 123I-epidepride was demonstrated in 9 of the 15 clinically non-functioning pituitary adenomas (60%), but specific binding of 123I-IBZM was shown in only 6 of these 15 cases (40%). The uptake of 123I-epidepride in the pituitary region was consistently higher than that of 123I-IBZM. None of the patients who showed absence of uptake of 123I-epidepride in the pituitary area showed uptake of 123I-IBZM in this area. In conclusion: 123I-epidepride SPET is superior to 123I-IBZM SPET for the visualization of dopamine receptor-positive pituitary adenomas. Therefore, 123I-epidepride should replace 123I-IBZM for future D2 receptor SPET studies of pituitary adenomas. 123I-epidepride SPET potentially might serve to predict the response of clinically non-functioning pituitary adenomas to dopamine agonist therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590050358
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