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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 40 (1977), S. 41-49 
    ISSN: 1432-0533
    Keywords: Brain death syndrome ; Anoxia ; Circulatory failure ; Fetal central nervous system ; Neuropathologic reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Report is given on the first example in which the clinical and electrographic criteria of brain death were obtained at birth. Global destruction of the central nervous system of a type seen only with anoxia and circulatory failure had occurredin utero without appreciable disturbance of maternal health. Neuropathologic reaction in fetal tissues was identical with that which has been observed in the child or adult in the brain death syndrome. Functional disturbance of cerebral spinal circulation of sufficient degree to destroy neuronal tissue had happened without change in maternal circulation and without demonstrable lesions in the placenta or the cardiovascular apparatus of the fetus.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1106
    Keywords: Homogenisation ; Fractionation ; Mouse cortex ; Isolated nuclei ; In situ nuclei
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to fractionate cortex nuclei into various classes reliable morphological criteria for the identification of isolated nuclei must be available. We have fractionated nuclei from mouse cortex on a discontinuous sucrose gradient into two fractions containing either large or small nuclei. Then we tried to identify them by comparison with in situ nuclei prepared by various techniques: paraffin embedded cortex sections stained by Nissl, cryostat sections of the cortex and corpus callosum unstained and stained with methylene blue (using phase contrast microscopy), cryostat sections of the cortex stained by Nissl and by the silver impregnation technique of Hortega-Maurer. However we found that isolated nuclei showed a completely different staining pattern after the centrifugation in high molar sucrose. Also the number of nucleoli and the size of the nuclei were not criteria sufficient to identify isolated nuclei as proposed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 37 (1979), S. 283-298 
    ISSN: 1432-1106
    Keywords: Cellular densities ; Cortical volume ; Postnatal undernutrition ; Maternal malnutrition ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Quantitative analysis of cellular densities as well as an estimate of the cortical volume and of its total cell population were performed on the cortex of postnatally undernourished mice (2–21 days) and on that of pups from malnourished mothers (gestation and lactation). Animals were followed until 180 days of age after more than 5 months of nutritional rehabilitation, and data were obtained at 10, 30, 60, and 180 days of age. The neuronal density was much higher in all cortical layers of the two experimental series, suggesting a delay in cortical maturation. Moreover, layers II, III, and IV were more delayed than layers I, V, and VI. Postnatal undernutrition had more severe effects than maternal malnutrition and the degree of recovery after a long rehabilitation was much less. The increase of the cortical volume was greatly reduced in postnatal undernutrition and to a lesser degree in maternal malnutrition. The total number of glial cells was also reduced more in postnatal undernutrition than in maternal malnutrition, but the total number of neurons was never smaller than in the controls.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 37 (1979), S. 299-308 
    ISSN: 1432-1106
    Keywords: Cerebral cortex ; Dendritic branchings and spines ; Postnatal undernutrition ; Protein maternal malnutrition ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Quantitative analysis of the dendritic branchings of pyramidal cells from layers V and III, as well as of the number of spines on their apical dendrites, were performed on the visual cortex of postnatally undernourished mice (2nd–21st day) and on that of pups from malnourished mothers (gestation and lactation). Animals were followed till 180 days of age after more than 5 months of nutritional rehabilitation, and data were obtained at 10, 15, 21, 30, 60, and 180 days of age. The increase and maturation of dendritic branchings and spines were much more reduced in postnatal undernutrition than in maternal malnutrition. Furthermore, permanent damage still remained at 180 days in postnatal undernutrition while almost no damage was statistically detectable after maternal malnutrition.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 38 (1980), S. 75-85 
    ISSN: 1432-1106
    Keywords: LGNd ; Quantitative development ; Bilateral and unilateral enucleation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Quantitative data (numbers of neurones and glial cells, total volumes, internuclear volumes) were obtained during normal development and after bilateral and unilateral enucleation at birth in the dorsal lateral geniculate nucleus (LGNd) of the mouse, at 5, 10, 30, 60, and 180 days postnatal. During normal development there is a neuronal loss of about 30% up to 30 days, at which age the total number of neurones stabilises at around 17,000. Glial proliferation and an increase in the volume of LGNd continues at least to 180 days. More severe degenerative effects were found after bilateral than after unilateral enucleation. At 180 days, bilateral enucleation leads to a neuronal loss of 27% compared to the controls, with a glial deficit of 53% and a decrease in the volume of LGNd of 57%. Degenerative effects were very different in LGNd contralateral or ipsilateral to enucleation in monocularly enucleated mice, due to the extensive crossing of the retinal fibres. At 180 days, we found a deficit of 10% in the numbers of neurones and glial cells, in the ipsilateral LGNd compared to normal: the volume of LGNd was slightly less (3%) than in controls. The contralateral LGNd after unilateral enucleation behaved like LGNd after bilateral enucleation until 60 days. At 180 days, some minor modifications were found, showing an additional neuropil decrease of 13% and an additional neuronal loss of 6% in the bilaterally enucleated LGNd compared to the unilaterally enucleated contralateral LGNd. The time-course of degeneration both after bilateral and unilateral enucleation was discussed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 216 (1977), S. 265-272 
    ISSN: 1432-1459
    Keywords: Coenurosis, cerebral ; Arteritis with coenurosis ; Cestodes, cerebral
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird ein ungewöhnliches zerebrales Krankheitsbild, welches durch eine Cönurose hervorgerufen war, beschrieben. Bei der seltenen Kombination einer meningovaskulären Läsion mit einer intrakraniellen Raumforderung soll immer die Möglichkeit einer Zestodenerkrankung (Echinokokkose, Zystizerkose, Cönurose) erwogen werden. Von diesen drei Krankheitsformen befällt lediglich die Cönurose isoliert das Gehirn. Die wiederholt angiographisch festgestellte Arteriitis der großen Hauptstämme äußerte sich klinisch durch wiederholte Halbseitenlähmungen. Der lumbale Liquor zeigte jeweils eine geringe Lymphozytose und eine Vermehrung der gamma-Globuline und der Immunglobuline. Diese entzündliche Reaktion wird durch die Anwesenheit der Parasiten als Fremdkörper, durch die Freisetzung von Toxinen und durch die immunologische Antwort des Wirtes hervorgerufen. Die Arteriitis selbst ist durch das Übergreifen der chronischen Leptomeningitis auf die Gefäßwand bedingt.
    Notes: Summary A case of the unusual clinical condition of cerebral coenurosis, the unique parasitic disease that is localized only in the CNS, is reported. The patient had repeated attacks of transient hemiparesis due to intracranial arteritis which was demonstrated by several angiographic studies. The CSF showed a discreet lymphocytosis and increased immunoglobulins. This inflammatory reaction which preceeded the manifestations of the intracranial mass can be explained by the parasitic foreign bodies, the liberation of somatic and metabolic parasitic toxins and the immunological reaction of the organism. The arteritis of the basal intracranial vessels was probably secondary to the inflammatory reaction of the leptomeninges. In presence of the rare association of meningovascular disease and an expanding intracranial lesion a parasitic condition due to a larval stage of Cestodes (Hydatidosis, Cysticercosis, Coenurosis) should be always considered.
    Type of Medium: Electronic Resource
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