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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 73 (1996), S. 205-205 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Retrovirus infectivity is the result of a cooperative interaction of three structural genes,gag, pol, andenv. Since the L-cell endogenous retrovirus (LCV) lacks theenv gene translation product, our aim was to study the biological and molecular basis of its non-infectiousness. Fusion experiments between LCV and homologous or heterologous cells demonstrated that virus production could be obtained only after LCV artificial penetration in murine cells and that the new progeny was still noninfectious. Northern blot analysis and heteroduplex mapping of the genomic RNA revealed a 0.99 kb deletion including the 3′ region of thepol reading frame, the whole xenotropic and part of the ecotropic domain of theenv gene. The results suggest that the observed deletion is responsible for the absence of the gp 70 and the gp 15 E molecules in the virion and seems therefore to be the molecular basis for the non-infectiousness of this retrovirus.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1590-3478
    Keywords: Computerised axial tomography (CT) ; central nervous system (CNS) ; fungal infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Le micosi profonde rappresentano un problema di sempre maggior rilievo nei pazienti immunosoppressi. Descriviamo tre pazienti affetti da emopatie maligne che in corso di infezione micotica sistemica hanno presentato interessamento cerebrale. La natura, la sede e l'estensione delle localizzazioni cerebrali sono state definite grazie alla TAC. In un paziente inoltre, è stato possibile seguire l'evoluzione della lesione e valutare l'efficacia del trattamento antifungino per la ripetibilità e la non invasività di questa metodica.
    Notes: Abstract Fungal infections of the CNS are becoming an increasingly serious problem in immunosuppressed patients. We describe three patients with malignant blood disease who in the course of systemic fungal infection presented cerebral involvement. The nature, site and extent of the cerebral involvement were defined by computed tomography (CT). Further, in one patient it was possible to follow the course of the lesion and assess the effectiveness of antimycotic therapy by CT because of its noninvasiveness and repeatability.
    Type of Medium: Electronic Resource
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