ISSN:
1420-9071
Keywords:
Pyruvate kinase
;
mouse transplanted tumors
;
tumor marker
;
L-cysteine
;
steatic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Mouse transplanted tumors, in contrast to normal tissues, contain a pyruvate kinase (PK) variant sensitive to the inhibitory action of L-cysteine and less sensitive to saturated fatty acids than the normal enzyme. In selected normal and tumor materials two fractions of PK were separated. Fraction A (20–30% (NH4)2SO4 saturation) dominated in normal liver, and fraction B (50–60% (NH4)2SO4 saturation) in skeletal muscles and Ehrlich ascites tumor. Only this fraction B from tumor material was sensitive to L-cysteine, and seems to contain a tumor-specific PK variant which might be considered as a marker of neoplastic transformation in a broad spectrum of mouse experimental tumors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01960231
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