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  • 1
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Knowledge of the accurate margins of a lentigo maligna melanoma (LMM) is crucial in the presurgical evaluation of the patient. Towards this end clinicians have utilized the Wood's lamp and dermoscopy to help delineate the borders of the LMM. However, many LMMs arise on photodamaged skin, making it difficult to determine the border of the LMM and separate it from the background lentiginous skin. We present a case of a patient with a recurrent LMM on the scalp that developed in a background of photodamage with diffuse melanocytic atypia and lentigines, making it virtually impossible to determine the precise margins of the LMM by clinical, Wood's lamp or dermoscopic examination. To avoid subjecting the patient to multiple staged excisions we attempted to determine the margins of the LMM by utilizing in vivo confocal laser scanning reflectance microscopy. Using this, it was apparent that there were increased numbers of atypical/dendritic intraepidermal melanocytes in all layers of the epidermis within the LMM. In contrast, skin not involved with the LMM, as viewed under confocal laser examination, had normal honeycomb architecture and no abnormal melanocytes. The confocally determined border was further confirmed by obtaining multiple punch biopsies that were evaluated by haematoxylin and eosin histology and immunohistochemistry. Based on this information, the presurgical margins were marked and the tumour excised accordingly. The excised tissue was examined with multiple-step sections and the margins were determined to be clear. There has been no evidence of tumour recurrence after 1 year. In conclusion, this case illustrates that confocal reflectance microscopy, in conjunction with other in vivo optical instruments, can be utilized to enhance the accuracy for the presurgical margin mapping of LMM.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 156 (1992), S. 341-347 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Although the metal content of the human body is only about 3%, metals are very important for human lives. Diseases occur when an excess or deficiency of in-vivo metals appear, when other metal pollutants enter the body, or when poisons or viruses enter into the metal ligand competition. Cancer is caused by carcinogens, which are substances capable of producing tumors in any test species at any dose level. This paper discusses the determination of some elements in diseased tissues of the human brain. As the elements present are mostly at micro- or nano-gram levels, the very sensitive technique of neutron activation analysis involving radiochemical separation has been employed. Substocihiometric estimations were carried out wherever possible. The radiochemical separation procedure includes a solvent extraction and precipitation technique. The elements estimated in the tissue samples are Cu, Au, As, Se, Hg, Co, Zn, Ca, Fe, P, Cr, Na, and K. The accuracy, precision, and radiochemical purity of the method have been discussed. Two samples and a standard can be analyzed in four days.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 96 (1985), S. 19-25 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A rapid and selective method for the extraction of Ag/I/ with 2-mercaptobenzothiazole/2-HMBT/ into chloroform has been developed. The effect of various parameters on the extraction coefficient of Ag/I/ such as pH, time of equilibration, solvents, anion interferences, cation interference and stoichiometry of the metal to reagent have been established.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 96 (1985), S. 293-300 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Ideal conditions for the extraction of Au/III/ with 2-mercaptobenzothiazole/2-HMBT/ into chloroform have been established. The effects of various parameters such as pH, time of equilibration, solvents, cation interferences, anion interferences and stoichiometry of the metal to reagent have been established.
    Type of Medium: Electronic Resource
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