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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Dental traumatology 6 (1990), S. 0 
    ISSN: 1600-0595
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Glutaraldehyde (GA) has been proposed as an alternative to formocresol for pulpotomies in primary teeth and as an irrigant in root canal therapy. These studies were undertaken to determine if GA can associate with the nucleus of living cells, thereby posing a mutagenic threat. Rats were infused IV with 14C-GA and killed 5 min and 1 h later. The cystolic, membrane, and nuclear fractions of harvested liver cells were separated and analyzed for radioactivity. We determined that significant radioactivity was located in the cytosol and membrane fractions, but not in the nuclear fraction. In an in vitro experiment, liver slices were incubated with 14C-GA in sealed vials in which 14C-CO2 was captured. After 1 h the nucleic acids of the liver slices were isolated and counted. In vitro the liver cells incorporated and metabolized GA to CO2 but no significant label could be detected in the isolated nucleic acids. We concluded from these experiments that GA which was incorporated into liver cells did not reach the nucleus to a significant extent, and that its potential for mutagenicity in the context of pulp treatment was nil.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 17 (1990), S. 0 
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract The aims of the present study were to examine, on the primary dentition of 75 human dried skulls, the distance from the cemento-enamel junction (CEJ) to the alveolar bone crest, and to evaluate its relation to developmental age, bone morphology and attrition. The measurements from the CEJ to the alveolar crest were longer for the maxillary teeth, the second molars showed the shortest measurements, while the cuspids showed the longest. Significant positive partial correlations were found between age and the distance from the CEJ to the alveolar crest when controlling for attrition (r=0.64), and between age and attrition when controlling for the distance from the CEJ to the alveolar bone crest (r=0.54). The partial correlation between migration and attrition when controlling for age proved to be not significant (r=0.13). Significant correlations were found between age and the distances from the mental foramen to: the alveolar crest (r=0.90), and to the lower border of the mandible (r=0.97). These findings suggest that root exposure takes place in the primary dentition, as the result of continuous eruption at a faster rate than formation of alveolar bone, presumably to compensate for facial growth.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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