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  • 1
    Electronic Resource
    Electronic Resource
    The first phase insulin response to intravenous glucose is highly reproducible (1990)
    Springer
    Diabetologia 33 (1990), S. 631-634 
    Details
    ISSN: 1432-0428
    Keywords: Acute phase insulin response ; first phase insulin response ; intravenous glucose tolerance test ; reproducibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine the reproducibility of the first phase insulin response to intravenous glucose, ten normal subjects underwent two intravenous glucose tolerance tests separated by at least two weeks. Intravenous dextrose (0.3 g/kg) was administered over 2 min by continuous infusion and arterialised-venous samples were taken from a retrogradely cannulated hand vein in the opposite arm. Within subjects, median coefficient of variation for the 3 min insulin was 4.0% (range 1.2–24.3%) and median coefficient of variation for the 0–10 min area was 6.7% (range 1.7–18.8%). These coefficients of variation are close to those of the assay itself (〈 10%). Despite this, between subject responses varied by greater than sixfold. In conclusion, contrary to previous reports the intravenous glucose tolerance test is highly reproducible. This makes it a very valuable tool for further studies of the pathogenesis of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400209
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dependent oedema and attenuation of postural vasoconstriction associated with nifedipine therapy for hypertension in diabetic patients (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 333-335 
    Details
    ISSN: 1432-1041
    Keywords: diabetes mellitus ; nifedipine ; hypertension ; oedema ; vasodilator ; blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We studied the incidence of oedema 2 weeks following initation of nifedipine therapy for hypertension in a group of 10 diabetic subjects, and also measured skin blood flow (SBF) with a laser Doppler flowmeter, before and after lowering the foot. SBF with the foot horizontal increased after nifedipine from 0.31V (arbitrary units of flow) to 0.51V (NS). The postural fall in blood flow in dependency was significantly attenuated by nifedipine from 64.4 to 24.0%. Five patients developed ankle oedema. Results were similar in a small group of non-diabetic subjects starting nifedipine. The attenuation of reflex postural vasoconstriction is therefore likely to contribute to development of the oedema associated with starting nifedipine therapy, which should be monitored carefully in diabetic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558495
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The anaesthetic management of a patient with a reninoma (2003)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 58 (2003), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report on the anaesthetic management of a 28-year-old woman presenting for excision of a reninoma. This is a very rare tumour of the juxtaglomerular cells of the kidney, which can be cured immediately by surgery. Previous reports have failed to record the presence or absence of peri-operative cardiovascular lability. We have shown that blood pressure, cardiac index (CI) and systemic vascular resistance (SVRI) were remarkably stable in our patient throughout surgery, even during manipulation of the tumour. Isolation of the tumour was associated with a 23% reduction in SVRI, and a similar decrease in blood pressure. The cardiovascular lability associated with the removal of catecholamine-secreting tumours was not seen in this case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.2003.03143.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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