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  • 1
    Electronic Resource
    Electronic Resource
    Acute bilateral brachial plexus neuritis associated with hypersensitivity vasculitis (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 643-645 
    Details
    ISSN: 1432-1440
    Keywords: Brachial plexopathy ; Churg-Strauss syndrome ; Sacral plexopathy ; Eosinophilia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The occurence of brachial plexus neuritis during the acute phase of vasculitis is uncommon. We describe a patient with a long history of rhinitis and a recent onset of asthma, who developed purpuric skin lesions, abdominal pain, eosinophilia and brachial neuritis along with evidence of sacral plexus neuropathy. High dose steroids and cyclophosphamide induced a remission. He stopped all medications after 3 years and after 6 years the patient has some fixed minimal residual neurological deficit. The importance of aggresive therapy in treating extensive polyneuropathy during the acute phase of hypersensitivity vasculitis is raised. A possible cytotoxic role of eosinophils in the pathological process is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732860
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Thymoma presenting as a superior vena cava syndrome remission following therapy (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 617-619 
    Details
    ISSN: 1432-1440
    Keywords: Thymoma ; Superior vena cava syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 45-year-old male developed myasthenia gravis 8 years ago. He received prednisone for 3 years, and resumed complete clinical remission. Five years later, he was admitted with obstruction of the superior vena cava. Invasive thymoma was diagnosed by chest X-ray and an open lung biopsy. Radiation followed by combination chemotherapy with cyclophosphamide, vincristine, and prednisone induced a complete remission. The patient remained disease-free for more than 20 months after the first admission to our department. To the best of our knowledge, superior vena cava syndrome as the presenting symptom of thymoma has never been reported previously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726671
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative pharmacokinetic analysis of a novel sustained-release dosage form of theophylline in humans (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 401-403 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; serum concentration ; sustained-release dosage form
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and relative bioavailability of theophylline from a new sustained-release formulation (Theotard®) and from a standard sustained-release formulation (Theo-Dur®) were compared in 6 healthy, adult, male volunteers. After a single oral dose of 300 mg Theotard, a mean maximal plasma concentration (Cbmax of 3.49±1.05 mg/l was obtained after 8 h (tmax). After an identical dose of Theo-Dur, a peak plasma concentration of 4.68±1.33 mg/l was obtained after 6.33 h. The mean relative bioavailability of theophylline from Theotard was 1.02±0.16 relative to that of Theo-Dur. In 5 of the volunteers the Theotard formulation exhibited a more prolonged and uniform absorption rate and yielded more sustained plasma levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548775
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of hyperglycaemia on the absorption of glibenclamide in patients with non-insulin-dependent diabetes mellitus (1994)
    Springer
    European journal of clinical pharmacology 47 (1994), S. 53-55 
    Details
    ISSN: 1432-1041
    Keywords: Glibenclamide ; Diabetes ; NIDDM ; absorption ; hyperglycaemia ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract We have studied the absorption of glibenclamide 10 mg as a single morning dose in 7 patients with non-insulin-dependent diabetes mellitus, comparing normoglycaemic and hyperglycaemic states. The maximal glibenclamide plasma concentrations were significantly higher in the normoglycaemic than in the hyperglycaemic state (448 vs 228 mg·1-1) and these peak concentrations were attained faster in normoglycaemia than in hyperglycaemia (3.7 vs 5 h). We conclude that the absorption of glibenclamide in the two states is different.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193478
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of valpromide after oral administration of a solution and a tablet to healthy volunteers (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 501-503 
    Details
    ISSN: 1432-1041
    Keywords: valpromide ; valproic acid ; pharmacokinetics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of valpromide, a primary amide of valproic acid, was investigated in 6 healthy, adult male volunteers, each of whom was given 900 mg as a marketed, enteric-coated tablet and a solution. Valpromide was biotransformed to valproic acid after the administration of the tablet and the solution with a bioavailability of 0.79±0.24 and 0.77±0.12, respectively, relative to a marketed tablet of valproic acid. The absorption of valpromide was not rate-limited by dissolution. As a solid, non-hygroscopic, neutral prodrug of valproic acid, valpromide may be a good alternative to valproic acid and sodium valproate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00549603
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  • 6
    Electronic Resource
    Electronic Resource
    Autoimmune hemolytic anemia in Gaucher's disease (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 94-95 
    Details
    ISSN: 1432-1440
    Keywords: Autoimmune hemolytic anemia ; Gaucher's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 23-year-old Ashkenazi woman with Gaucher's disease developed Coombs-positive warm-type autoimmune hemolytic anemia. Treatment with high-dose steroids resulted in complete remission within 2 weeks. Study of an additional 72 patients with Gaucher's disease revealed another case of Coombs-positive warm-type autoimmune hemolytic anemia; other autoimmune disorders were found in 17 of these patients. The possible association of Coombs-positive hemolytic anemia and Gaucher's disease is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646850
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  • 7
    Electronic Resource
    Electronic Resource
    Glibenclamide causing thrombocytopenia and bleeding tendency: Case reports and a review of the literature (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 223-224 
    Details
    ISSN: 1432-1440
    Keywords: Thrombocytopenia ; Glibenclamide ; Bleeding tendency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe two patients with severe thrombocytopenia and bleeding tendency related to treatment with glibenclamide (short-acting sulfonylurea). To the best of our knowledge, thrombocytopenic purpura associated with this medication has been reported only twice previously. We suggest that platelet count should be carried out early after initiating glibenclamide treatment and every 3 months thereafter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728201
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  • 8
    Electronic Resource
    Electronic Resource
    Reduced negative surface charge on arterial endothelium of diabetic rats (1988)
    Springer
    Diabetologia 31 (1988), S. 618-620 
    Details
    ISSN: 1432-0428
    Keywords: Cationized ferritin ; negative charge ; endothelium ; diabetic rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cationized ferritin binding was used to measure negative surface charge on endothelium of large arteries in streptozotocin-induced diabetic rats and normal control rats. The negative charge was significantly lower in the diabetic animals (p〈0.01). This change, possibly related to glycosylation, may lead to altered vascular permeability and may be of importance in the vascular pathology of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00264770
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  • 9
    Electronic Resource
    Electronic Resource
    Altered tissue content of trace metals in diabetic hyperinsulinaemic sand rats (psammomys obesus) (1988)
    Springer
    Diabetologia 31 (1988), S. 329-333 
    Details
    ISSN: 1432-0428
    Keywords: Sand rats ; trace metals ; zinc ; copper ; chromium ; diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The concentrations of zinc, copper, and chromium in liver, kidney, muscle, bone and serum from control normoinsulinaemic and hyperinsulinaemic sand rats (Psammomys obesus) and from untreated spontaneously hyperinsulinaemic-hyperglycaemic sand rats were compared. A chronic hyperinsulinaemic-hyperglycaemic state was associated with a significant reduction (p〈0.01) of zinc concentration in the liver, kidney and muscle but an elevation of zinc content in bone and of chromium in the liver. A hyperinsulinaemic-normoglycaemic state was not associated with similar changes in zinc concentration in the liver, kidney, muscle and bone. We conclude that in hyperinsulinaemic-hyperglycaemic sand rats there is a tendency to zinc depletion in several tissues. This depletion is not solely the result of a hyperinsulinaemic state but may be related to accompanying hyperglycaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277416
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  • 10
    Electronic Resource
    Electronic Resource
    Prevalence of diabetes mellitus among workers in Israel:¶a nation-wide study (1999)
    Springer
    Acta diabetologica 36 (1999), S. 169-172 
    Details
    ISSN: 1432-5233
    Keywords: Key words Prevalence ; Undiagnosed diabetes ; IGT ; National study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The prevalence of diabetes mellitus in Israel has been described in various populations and ranges from 4.1% to 8.9%. However, the large immigration wave in the late 1980s and early 1990s could have affected the previous estimates. Moreover, data from the United states and other countries report a significant proportion of undiagnosed diabetes. The main purpose of this study was to estimate the prevalence and the ratio of undiagnosed/diagnosed diabetes in a large sample of workers. The study involved interviews, anthropometric measurements at the work site, and blood glucose determinations (casual capillary, fasting, and when necessary, 2 h after a 75-gram oral glucose load). Diabetes and impaired glucose tolerance (IGT) were diagnosed according to WHO criteria. Five thousand four hundred sixteen workers participated in the study. Three hundred ten reported to be known diabetics (5.7%), 35 (0.7%) were diagnosed as diabetic during the survey, and an additional 93 (1.8%) were classified as IGT. The ratio undiagnosed/diagnosed diabetes was therefore 1:10. Extrapolation of these results produced an estimate of diabetes prevalence in Israel of 10% among people over age 40 years. It seems that in the Israeli health care system, based on universal health insurance and easy access to primary care, the proportion of undiagnosed diabetes is lower than that described in other countries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005920050162
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