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  • 1
    Electronic Resource
    Electronic Resource
    Accumulation of lipid in muscular arteries of short-term diabetic rats (1980)
    Springer
    Diabetologia 19 (1980), S. 529-534 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; streptozotocin ; coronaryartery ; muscular pulmonary artery ; tibial artery ; aorta ; main pulmonary artery ; elastic arteries ; plasmanon-esterified fatty acid (NEFA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lipid accumulation in muscular (pulmonary, coronary and tibial) arteries and elastic (aorta and pulmonary) arteries of streptozotocin diabetic (65 mg/kg) rats was studied with an electron microscope. Arterial tissue specimens taken 4 days after the induction of diabetes showed lipid deposits in smooth muscle cells in the muscular arteries of 9 out of 24 diabetic rats, but in none of the 17 control rats. Histochemically the lipid was identified as triacylglycerol. Lipid accumulation was not seen in the elastic arteries of either diabetic or control rats. The diabetic animals with lipid deposits had slightly but significantly higher plasma glucose concentrations (p〈0.02), higher non-esterified fatty acids levels (p〈0.01), and lower concentrations of plasma insulin (p〈0.02) than those without arterial deposits. The amount of lipid deposited in the arteries was closely related to the plasma non-esterified fatty acid level, which was in the ranges 0.8–1.1 mmol/l in diabetic rats without deposits, and 1.1–2.4 mmol/l in those with deposits. The findings suggest that lipid accumulation in smooth muscle cells of muscular arteries during acute diabetes could result from the high plasma non-esterified fatty acid concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253180
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of insulin on the lipids in the pulmonary artery and the lungs of severely diabetic rats (1979)
    Springer
    Diabetologia 16 (1979), S. 59-64 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; insulin ; non-esterified fatty acids ; lipid metabolism ; lung ; phospholipids ; pulmonary artery ; rat ; streptozotocin ; triglycerides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of insulin on the triglyceride deposits found in the pulmonary artery branches of streptozotocin-diabetic rats was investigated by treating the animals for two, five, nine or 14 days with insulin (3–8 units/day). Histochemical analysis showed that the triglyceride deposits in the pulmonary artery developed within three to four days after the induction of diabetes, but were not present in any animals five days from the initiation of insulin therapy. Plasma triglycerides, non-esterified fatty acids, phospholipid and total cholesterol concentrations were within the normal range within two days of the inception of insulin therapy and random plasma glucose levels were normal within five days. Analysis of lung lipids showed that after 14 days of insulin treatment the decreased content of phospholipids and the increased content of non-esterified fatty acids found in diabetic rats were also normalized. These findings suggest that insulin has an important role in the regulation of lipid metabolism in the pulmonary artery and lung tissue in the diabetic state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00423152
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Long-term effects of untreated diabetes on the arterial wall in rat (1981)
    Springer
    Diabetologia 20 (1981), S. 205-212 
    Details
    ISSN: 1432-0428
    Keywords: Arterial wall ; streptozotocin ; diabetes ; rat ; electron microscopy ; non-esterified fatty acids ; basement membrane thickening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Arterial ultrastructure was examined in twelve untreated streptozotocin-diabetic rats. Five showed severe changes in muscular (coronary, tibial, pulmonary) arteries two months after induction of diabetes. The basement membrane of smooth muscle cells was patchily thickened in these arteries. No similar changes were seen in muscular arteries of the other seven diabetic rats or in 10 control rats. No lesions were found in elastic arteries (aorta, main pulmonary artery) of any diabetic or control animals. Plasma non-esterified fatty acids, total ketone bodies, and glucose levels were higher in the diabetic rats with arterial changes (p〈0.01) than in the diabetic animals without such changes. The molar ratio of non-esterified fatty acid to albumin in plasma ranged between 2.3–3.3 in the diabetic rats with arterial lesions, 1.4–1.8 in those without such features, and 0.6–1.1 in the controls. The excess of nonesterified fatty acid in plasma during insulin deficiency could be an important factor in the initiation of arterial changes in this model of experimental diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252629
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Lipids in the pulmonary artery and the lungs of severely diabetic rats (1977)
    Springer
    Diabetologia 13 (1977), S. 305-310 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; non-esterified fatty acids ; lipid metabolism ; lung ; phospholipids ; pulmonary artery ; rat ; streptozotocin ; triglycerides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the effect of diabetes on the lipid composition of the lungs and of the pulmonary artery, 43 streptozotocin diabetic rats and 43 control rats were examined. Triglyceride deposits were observed by a histochemical method in the branches of the pulmonary artery in 10 diabetic rats but in none of the controls. In the pulmonary tissue of the diabetic rats the total lipid content was not different from that of control animals, but the relative amount of phospholipids was decreased (p〈0.001), and that of non-esterified fatty acids (p〈0.001) and triglycerides (p〈0.05) increased as compared to the control rats. These results indicate abnormalities in the lipid metabolism of the pulmonary artery and lungs during insulin deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01223270
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructure of heart muscle in short-term diabetic rats: influence of insulin treatment (1984)
    Springer
    Diabetologia 27 (1984), S. 397-402 
    Details
    ISSN: 1432-0428
    Keywords: Ultrastructure ; heart muscle ; streptozotocin ; short-term diabetes ; insulin treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of myocardium was examined in short-term diabetic rats. Morphometric analysis showed the volume of myocytic mitochondria, sarcoplasmic reticulum and lipid droplets to be significantly increased compared with those of control animals. Further measurements of mitochondria and sarcoplasmic reticulum indicated that the augmentation of these compartments was accountable by the enlargement of pre-existing mitochondria, which were swollen, and of pre-existing tubules of sarcoplasmic reticulum, the lumen of which was dilated. After insulin treatment the morphological changes were returned to normal which indicates that they were not due to the toxic effect of streptozotocin but were caused by the diabetic state per se. This suggestion is further supported by the finding that experimentally induced metabolic acidosis without diabetes did not cause any morphologically detectable changes in the heart muscle. It is concluded that short-term diabetes in the rat causes mitochondrial swelling, dilatation of sarcoplasmic reticulum and accumulation of lipid in cardiac myocytes, and that these changes are preventable with insulin treatment. We suggest that insulin may have an important role in the maintenance of metabolism in heart muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304857
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    Paper (German National Licenses)
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