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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population (1991)
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 369-370 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We describe a simple method for characterizing a frequent polymorphism (that subsitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. We could find no evidence that this polymorphism is associated with a marked predisposition to colorectal cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201836
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  • 2
    Electronic Resource
    Electronic Resource
    Role of genetic factors in bronchial cancer. Based upon a case of anaplastic lung carcinoma in identical twins (1995)
    Springer
    Human genetics 〈Berlin〉 96 (1995), S. 483-484 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Having observed homozygotic identical twin brothers suffering simultaneously from anaplastic bronchial cancer leading rapidly to death in both cases, the authors assessed the frequency of such cases. The available literature failed to reveal any identical observations, although four cases of twins suffering from bronchial cancer featuring different histologies (three epidermoidal and one bronchiolar-alveolar) were noted. Statistics show that, in the area where the observed twins were living, anaplastic cancer occurs each year in 0.39% of 53-year-old men. The case of these twins therefore supports the idea of the role of genetic factors in the determination of bronchial cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191812
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  • 3
    Electronic Resource
    Electronic Resource
    Obstructive lesions of the central airways: evaluation by using spiral CT with multiplanar and three-dimensional reformations (1996)
    Springer
    European radiology 6 (1996), S. 807-816 
    Details
    ISSN: 1432-1084
    Keywords: Spiral CT ; Multiplanar reformations ; Three-dimensional reconstructions ; Central airways
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to assess the accuracy of transverse CT scans as well as multiplanar (MPR) and three-dimensional (3D) reconstructions in the evaluation of obstructive lesions of the central airways. A total of 64 patients were evaluated for the presence of obstructive lesions of the central tracheobronchial tree with transverse spiral CT scans, multiplanar reformations (MPRs), 3D shaded surface displays (3D SSDs) and minimum intensity projections (MIPs). The findings of these modalities were then compared with those obtained at bronchoscopy. The severity, length, and shape of airway narrowing were analyzed comparatively on the four sets of images. Transverse CT scans and MPRs had a similar accuracy (99%) in detecting obstructive airway lesions. The accuracy of both was significantly higher than that of 3DSSDs (90%, p 〈0.05) and MIPs (81%; p 〈 0.01). There was no statistically significant difference between the four imaging modalities in the analysis of the morphology of airway stenoses. Symmetric stenoses were similarly analyzed on the four sets of images, whereas MPRs and MIPs failed to depict accurately simple and complex asymmetric stenoses. Transverse CT scans are accurate in the depiction of obstructive lesions of the central airways and may be complemented by MPRs and/or 3DSSDs in their morphologic evaluation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00240676
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  • 4
    Electronic Resource
    Electronic Resource
    Spiral CT of pulmonary embolism: diagnostic approach, interpretive pitfalls and current indications (1998)
    Springer
    European radiology 8 (1998), S. 1376-1390 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Spiral CT ; Pulmonary circulation ; Acute pulmonary embolism ; Chronic thromboembolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The introduction of spiral CT has recently modified the diagnostic work-up of pulmonary embolism, because it is possible to depict noninvasively endoluminal clots in second- to-fourth-division pulmonary arteries. If this technique is currently considered a powerful imaging alternative for the detection of acute central emboli, it is mainly related to the possibility to obtain a uniform and high degree of arterial enhancement of pulmonary arteries down to 2–3 mm in diameter. Minimal experience in spiral CT angiography is necessary to achieve this goal and requires familiarity with both data acquisition and contrast medium injection. Numerous interpretive pitfalls exist in assessing spiral CT images, and certain caveats have to be heeded. However, their recognition becomes increasingly less problematic as the radiologist gains experience with spiral CT of the pulmonary vasculature. Therefore, the purpose of this article is to review the diagnostic approach to pulmonary embolism with spiral CT, with special emphasis on protocol parameters and scan interpretation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050557
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  • 5
    Electronic Resource
    Electronic Resource
    Multiplanar and three-dimensional reconstruction techniques in CT: impact on chest diseases (1998)
    Springer
    European radiology 8 (1998), S. 335-351 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Multiplanar imaging ; 3D reconstructions ; Spiral CT ; Thoracic diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this review is to capture the current state-of-the art of the technical aspects of multiplanar and three-dimensional (3D) images and their thoracic applications. Planimetric and volumetric analysis resulting from volumetric data acquisitions obviates the limitations of segmented transverse images. Among the 3D reconstruction techniques currently available, the most recently introduced technique, i. e., volume rendering, has to be evaluated in comparison with 3D shaded surface display and maximum or minimum intensity projection. Slabs are useful in detecting and localizing micronodular or microtubular patterns and in analyzing mild forms of uneven attenuation of the lungs. Three-dimensional angiography is helpful in the pretherapeutic evaluation and posttreatment follow-up of pulmonary arteriovenous malformations, in the comprehension of the postoperative reorientation of the pulmonary vessels, in the surgical planning of pulmonary tumors, and in the diagnosis of marginated thrombi. The systemic supply to the lung and superior vena cava syndromes are also relevant to these techniques. In acquired or congenital tracheobronchial diseases including stenosis, extraluminal air and complex airway anatomy, multiplanar and 3D reformations have a complementary role to both transaxial images and endoscopy. New developments are also expected in various topics such as 3D conformal radiation therapy, planning of intraluminal bronchoscopic therapy, virtual endoscopy, and functional imaging of the bronchial tree. Miscellaneous clinical applications are promising in the analysis of diaphragmatic morphology and pathophysiology, in the volumetric quantification of the lung parenchyma, and in the vascular components of the thoracic outlet syndromes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050391
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  • 6
    Electronic Resource
    Electronic Resource
    Rapid purification of the Aeromonas proteolytica aminopeptidase: Crystallization and preliminary X-ray data
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 294 (1992), S. 91-97 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(92)90141-I
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  • 7
    Electronic Resource
    Electronic Resource
    Human auto-anti-idiotypic antibodies to mite-specific IgE can degranulate human basophils in vitro (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Anti-idiotypic antibodies (anti-Ids) to specific IgE antibodies are formed spontaneously during an anti-allergen immune response and can be induced by immunotherapy. Although anti-Ids can down-regulate the production of IgF. antibodies, at least in experimental models, their possible role in the modulation of target cell reactivity remains ill-defined.Objective The capacity of human anti-Ids to modulate the release of histamine was examined in an in vitro system of human basophil degranillation. Anti-Ids were prepared from the serum of six Dermatophagoides pteranyssinus (DP)-hypersensitive patients suffering from atopic dermatitis and who had never been desensitized. Basophils were obtained from the blood of atopic donors. The extent of histaminc release was determined using a fluorometric assay.Results We show that: anti-Ids trigger the release of histamine in an allergen-specific, dose- and IgE-dependent manner; the release is not due to the presence of allergen and/ or anti-IgE antibodies: and that the degranulating activity can be removed by absorption with affinity-purified anti-Dp antibodies of the corresponding patient.Conclusion These results indicate that spontaneously produced human anti-Ids can modulate the reactivity of human basophils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1995.tb00395.x
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  • 8
    Electronic Resource
    Electronic Resource
    Complexes of grass pollen allergens and specific antibodies reduce allergic symptoms and inhibit the seasonal increase of IgE antibody (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Complexes made from antigen and specific antibodies have been used to suppress specific antibody production. This property is of potential therapeutic interest in immediate hypersensitivily states which are characterized by hyperproduction of IgE antibodies. We report here on the use of antigen-antibody complexes in patients with hypersensitivity to grass pollen. Specific anti-allergen antibodies were prepared by immunoadsorption from the serum of hypersensitive individuals and mixed with grass pollen allergens to form complexes in antibody excess. These complexes were used in a strictly autologous manner for inoculating patients prior to and during a pollen season. The study comprised two randomly defined groups of 15 patients who were inoculated intradermally either with a preparation of allergen-antibody complexes or with the carrier buffer, according to a double-blind protocol. Diary cards were used to follow nasal and ocular symptoms, bronchial asthma and medication intake. Specific IgE antibodies were assayed during the trial and 1 year afterwards.Inoculation of allergen-autologous antibody complexes was well tolerated. It significantly reduced ocular symptoms (Mann-Whitney U-test, P 〈 0·05), bronchial asthma during the first part of the season (Mann-Whitney U-test, P 〈 0·001) and drug intake (Mann-Whitney U-test, P 〈 0·001). This treatment prevented the seasonal increase in specific IgE antibodies, whose production continued to decrease after the pollen season. These effects were obtained within a few weeks of treatment, using a cumulative amount of allergen 100-fold lower than the amount which would have been used for a conventional hyposensitization.Inoculation of allergen-antibody complexes might prove to be a valuable alternative for the treatment of immediate hypersensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1990.tb02704.x
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  • 9
    Electronic Resource
    Electronic Resource
    New high-technology products for the treatment of haemophilia (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Haemophilia 10 (2004), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  This review will focus on new technologies in development that promise to lead to further advances in haemophilia therapeutics. There has been continued interest in the bioengineering of recombinant factor VIII (rFVIII) and factor IX (rFIX) with improved function to overcome some of the limitations in current treatment, the high costs of therapy and to increase availability to a broader world haemophilia population. Bioengineered forms of rFVIII, rFIX or alternative haemostatic molecules may ultimately have an impact on improving the efficacy of therapeutic strategies for the haemophilias by improving biosynthesis and secretion, functional activity, half-life and immunogenicity. Preventing and suppressing inhibitors to factor (F) VIII remain a challenge for both clinicians and scientists. Recent experiments have shown that it is possible to obtain anti-idiotypic antibodies with a number of desirable properties: (i) strong binding avidity to FVIII inhibitors; (ii) neutralization of inhibitory activity both in vitro and in vivo; (iii) cross-reactivity with antibodies from unrelated patients, and (iv) no interference with FVIII function. An alternative, although complementary approach, makes use of peptides derived from filamentous-phage random libraries. Mimotopes of FVIII can be obtained, which bind to the paratope of inhibitory activity and neutralize their activity both in vitro and in vivo. In this paper, we review advanced genetic strategies for haemophilia therapy. Until recently the traditional concept for gene transfer of inherited and acquired haematological diseases has been focused on how best to obtain stable insertion of a cDNA into a target-cell genome, allowing expression of a therapeutic protein. However, as gene-transfer vector systems continue to improve, the requirement for regulated gene transcription and hence regulated protein expression will become more critical. Inappropriate protein expression levels or expression of transferred cDNAs in non-intended cell types or tissues may lead to target-cell toxicity or activation of unwanted host immune responses. Regulated protein expression requires that the transferred gene be transferred with its own regulatory cassette that allows for gene transcription and translation approaching that of the normal gene in its endogenous context. New molecular techniques, in particular the use of RNA molecules, now allow for transcription of corrective genes that mimic the normal state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2004.00996.x
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  • 10
    Electronic Resource
    Electronic Resource
    Inhibitors in haemophilia: pathophysiology (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Haemophilia 10 (2004), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Development of inhibitors to coagulation factors is one of the major problems faced by people with haemophilia. Up to a third of patients, following treatment with factor concentrates, will develop an antibody (inhibitor) to that factor, rendering it inactive, and leaving the patient at risk from life-threatening bleeding. Evidence shows that this immune response is T-cell-dependent, but as yet, the epitopes responsible have not been identified. Risk for inhibitor development is highest within the first 50 days of treatment, with reactions being rare after 200 days. The risk is mediated by the major histocompatibility complex class of the patient, and by mutations in the factor VIII genotype, with large deletions conferring greatest risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2004.01009.x
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