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  • 1
    ISSN: 1432-1106
    Keywords: Key words Intracortical inhibitory circuits ; Brain stimulation ; Motor cortex ; descending volleys ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A magnetic transcranial conditioning stimulus given over the motor cortex at intensities below threshold for obtaining electromyographical (EMG) responses in active hand muscles can suppress responses evoked in the same muscles at rest by a suprathreshold magnetic test stimulus given 1–5 ms later. In order to define the mechanism of this inhibitory effect, we recorded descending volleys produced by single and paired magnetic transcranial stimulation of motor cortex through high cervical, epidural electrodes implanted for pain relief in two conscious subjects with no abnormality of the central nervous system. The conditioning stimulus evoked no recognisable descending activity in the spinal cord, whilst the test stimulus evoked 3–4 waves of activity (I-waves). Conditioning stimulation suppressed the size of both the descending spinal cord volleys and the EMG responses evoked by the test stimulus. Inhibition of the descending spinal volleys was most pronounced at ISI 1 ms and had disappeared by ISI 5 ms. It was evident for all components following the I1-wave, while the I1-wave itself was not inhibited at all. We conclude that a small conditioning magnetic stimulus can suppress the excitability of human motor cortex, probably by activating local cortico-cortical inhibitory circuits.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1590-3478
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 5 (1984), S. 423-432 
    ISSN: 1590-3478
    Keywords: Proximal Spinal Muscular Atrophy ; clinical features ; classification ; inheritance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Gli autori riportano le proprie esperienze su 89 casi di amiotrofie spinali prossimali facendo alcune considerazioni sulle caratteristiche cliniche. Nel discutere i criteri di classificazione e le modalità di trasmissione, gli autori suggeriscono l'ipotesi che le singole forme in cui è divisa l'amiotrofia spinale prossimale possano essere considerate come una malattia unitaria con ampia variabilità per età di esordio e gravità, dovuta generalmente, alla trasmissione di un gene autosomico recessivo.
    Notes: Abstract A report on 89 cases of proximal Spinal Muscular Atrophy with observations on the clinical features, criteria of classification and modes of inheritance. The various forms into which SMA is divided probably represent a single disease that may begin at any age and may vary in severity, due, as a rule, to an autosomal recessive gene.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 11 (1990), S. 309-312 
    ISSN: 1590-3478
    Keywords: Neurosyphilis ; somatosensory evoked potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Gli autori riportano le caratteristiche dei potenziali evocati somatosensoriali del nervo mediano e peroneo comune in un paziente affetto da tabe dorsale. I potenziali evocati somatosensoriali sono risultati nei limiti della norma stimolando il nervo mediano ma di latenza aumentata per il nervo peroneo comune. Ciò risultava in accordo sia con le caratteristiche cliniche di segni di interessamento dei cordoni posteriori limitato al tratto lombosacrale che con le caratteristiche anatomopatologiche della neurosifilide.
    Notes: Abstract Here we report median and common peroneal nerve SEPs in a patient with tabes dorsalis. SEPs were within normal limits following median nerve stimulation, but of prolonged latency for common peroneal nerve. This was in keeping with clinical findings of posterior column involvement confined to the lumbosacral tract and with pathological features of tabetic neurosyphilis.
    Type of Medium: Electronic Resource
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