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  • 1
    Electronic Resource
    Electronic Resource
    VENOCONSTRICTION CAUSES DIFFERENT EFFECTS IN THE HINDQUARTERS VENOUS COMPARTMENT OF CATS AND DOGS (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 14 (1987), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. A study was made of venoconstrictor mechanisms in the hindquarters region of cats and dogs by the use of autoperfused hindquarter preparations, together with the measurement of vena cava blood flow (VCBF).2. Noradrenaline, adrenaline and angiotensin II (AII) were all administered intraarterially and their ability to alter perfusion pressure and VCBF was examined.3. All three drugs increased perfusion pressure in both cats and dogs as a result of increases in arterial resistance. At the same time, noradrenaline and adrenaline increased VCBF in cats, while AII had a variable effect. In contrast, all three drugs decreased VCBF in dogs.4. These differences in the venoconstrictor responses obtained in cats and dogs may be explained by an action of the drugs at different loci within the venous compartment of the two species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1987.tb01882.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    THE EFFECT OF NARCOTIC ANALGESICS AND THEIR ANTAGONISTS ON CONDITIONED AVOIDANCE IN THE RAT (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 1 (1974), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY 1. To investigate the hypothesis that some degree of tranquillizer activity is a necessary component of analgesic activity, several narcotic analgesic drugs and narcotic antagonists were tested for their ability to block a conditioned avoidance response in rats, and their actions were compared with those of chlorpromazine and chlordiazepoxide.2. Morphine, oxymorphone, oxycodone and codeine specifically blocked the avoidance response in a dose-dependent manner, in doses comparable with those having antinociceptive action. Neither nalorphine nor naloxone had any significant effect on the avoidance response, but they caused a parallel shift of the dose-response curve of morphine to the right.3. Pentazocine specifically blocked avoidance to about 50% in low and intermediate doses, but the highest dose used blocked both avoidance and escape.4. Chlorpromazine was potent in blocking the avoidance response, and nalorphine did not interfere with this action. Chlordiazepoxide had only a slight effect in blocking the avoidance response.5. Interference with 5-hydroxytryptamine metabolism had no effect on the action of narcotics on conditioned avoidance; this finding is difficult to reconcile with the hypothesis that 5-hydroxytryptamine is involved in the analgesic action of morphine.6. The results are consistent with the hypothesis that tranquillizer action is a necessary component of analgesia and may provide a basis for more complete screening of potential analgesics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1974.tb00571.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    EFFECTS OF CLONIDINE ON VASCULAR RESPONSES IN KIDNEY AND HINDLIMBS OF CATS (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Cardiovascular reflexes to intravenous adrenaline and histamine and to carotid occlusion were studied in the renal vasculature, and direct effects of nor-adrenaline and clonidine were compared in renal and hindlimb vascular beds in anaesthetized cats.2. Unlike its reported effects on cardiovascular reflexes in the hindlimbs, clonidine depressed all three reflexes in the kidneys.3. Noradrenaline caused vasoconstriction when given directly into both renal and hindlimb circulations, but clonidine produced vasoconstriction only in the hindlimb vascular bed.4. These results suggest that α-adrenoceptors in the renal vasculature may be different from those in the hindlimbs, and that the cardiovascular reflexes in these two areas are under different control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00642.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A water Cherenkov counter sensitive to nonwaveshifted ultraviolet Cherenkov photons
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 252 (1986), S. 112-118 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(86)90947-2
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The use of n-hexane in the gas mixture for streamer tubes
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 276 (1989), S. 140-143 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(89)90626-8
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    In vivo efficacy of albendazole againstGiardia duodenalis in mice (1991)
    Springer
    Parasitology research 77 (1991), S. 325-328 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The antigiardial effects of albendazole were demonstrated in vivo using experimental infections ofGiardia duodenalis in mice. These results complement previous in vivo studies in which albendazole was shown to have more potent antigiardial action than the currently applied antigiardial drugs. In mice, 2–4 doses (〉100 mg/kg twice daily) were required for complete inhibition of cyst excretion and full elimination of trophozoites from the small intestine. The high doses necessary in mice were not unexpected and are discussed in light of the possible pharmacokinetics of albendazole in the animal model used in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00930909
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Blood flow measurement during exercise in sheep using Doppler ultrasonic method (1981)
    Springer
    Medical & biological engineering & computing 19 (1981), S. 373-376 
    Details
    ISSN: 1741-0444
    Keywords: Continuous flow record ; Coronary blood flow ; Doppler ultrasonic record of blood flow ; Hindlimbs ; Kidney ; Treadmill exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Continuous recording of blood flow to the coronary, renal and hindlimb vascular beds of sheep has been carried out using flow probes implanted around the major vessels supplying these regions. Blood flow has been recorded at rest, with the sheep running at speeds of 1–16 kmh−1 on a treadmill, and during the recovery period. A Doppler flowmeter has been developed to facilitate compatibility with existing equipment, to enable reliable reproduction of the unit and to keep costs to a minimum. To minimize interference accompanying the violent movements of exercise great care must be taken with the electrical connections and flow probes require streamlining to facilitate implantation. Blood flow to both hindlimb and coronary vascular beds increased during exercise while that to the renal vascular bed did not change. Thus continuous recording with the Doppler ultrasonic flowmeter can be utilised during all phases of exercise, unlike other methods such as the use of radioactive microspheres which provides only point estimations and has limited application for repeated measurement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442563
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    Paper (German National Licenses)
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