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  • 1
    Electronic Resource
    Electronic Resource
    Humour and alarmism in melanoma prevention: a randomized controlled study of three types of information leaflet (1999)
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 140 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Effectiveness of melanoma prevention depends on how it is accepted by the population. Humour and alarmism are often used in campaigns, but no information is available about how much they may improve or limit the impact of a campaign. Three different leaflets containing the same information about sun exposure and skin cancers were developed using three different tones of presentation: humoristic (H-leaflet), alarmist (A-leaflet) or neutral information (N-leaflet). In this randomized controlled study, each type of leaflet was mailed to a sample of 300 subjects representative of the sociodemographic population of the South of France. A fourth sample to whom no leaflet was sent was used as a control. Fifteen days after the mailing, the 1200 individuals were interviewed by phone. Four hundred and forty-four of the 900 who received the mail read the leaflet. The percentage of individuals with a good awareness of melanoma was higher in leaflet groups than in controls. The percentage of individuals who read a leaflet was lower in the A-leaflet group and the percentage of individuals knowing what a melanoma is tended to be lower in the H-leaflet group. There was no significant difference between groups with regard to ability for self-assessment of skin sun sensitivity, risk factors and sun exposure. The tone of presentation seems to have a limited impact on the effect of a campaign, but alarmism tends to reduce the number of people reached by the message whereas humour tends to decrease the impact of the message.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.02824.x
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  • 2
    Electronic Resource
    Electronic Resource
    Role of fatty acid-binding protein in cardiac fatty acid oxidation (1990)
    Springer
    Molecular and cellular biochemistry 98 (1990), S. 149-159 
    Details
    ISSN: 1573-4919
    Keywords: FABP ; fatty acid ; cardiac energy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Although abundant in most biological tissues and chemically well characterized, the fatty acid-binding protein (FABP) was until recently in search of a function. Because of its strong affinity for long chain fatty acids and its cytoplasmic origin, this protein was repeatedly claimed in the literature to be the transcytoplasmic fatty acid carrier. However, techniques to visualize and quantify the movements of molecules in the cytoplasm are still in their infancy. Consequently the carrier function of FABP remains somewhat speculative. However, FABP binds not only fatty acids but also their CoA and carnitine derivatives, two typical molecules of mitochondrial origin. Moreover, it has been demonstrated and confirmed that FABP is not exclusively cytoplasmic, but also mitochondrial. A function for FABP in the mitochondrial metabolism of fatty acids plus CoA and carnitine derivatives would therefore be anticpated. Using spin-labelling techniques, we present here evidence that FABP is a powerful regulator of acylcarnitine flux entering the mitochondrial β-oxidative system. In this perspective FABP appears to be an active link between the cytoplasm and the mitochondria, regulating the energy made available to the cell. This active participation of FABP is shown to be the consequence of its gradient-like distribution in the cardiac cell, and also of the coexistence of multispecies of this protein produced by self-aggregation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00231379
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  • 3
    Electronic Resource
    Electronic Resource
    Thermal decomposition of tetraamineplatinum(II) chloride by simultaneous TG/DTG/DTA/MS and direct insertion probe mass spectrometry (1987)
    Springer
    Journal of thermal analysis and calorimetry 32 (1987), S. 825-834 
    Details
    ISSN: 1572-8943
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Simultane Thermogravimetrie (TG), derivative Thermogravimetrie (DTG), Differentialthermoanalyse (DTA) und Analyse der entwickelten Gase (EGA) durch Massenspektrometrie (MS) wurden zur Bestimmung des Reaktionsverlaufs bei Zersetzung von Tetraminplatin(II)-chlorid sowie cis- und trans-Diaminplatin(II)-chlorid herangezogen. Die eindeutige Identifizierung der entwickelten Gase erfolgte durch Massenspektrometrie mit direkter Probeneinführung. Die thermische Zersetzung von (NH3)4PtCl2 erfolgt in zwei Schritten. Der erste ist die endotherme Abspaltung von zwei Mol Ammoniak unter Bildung eines Gemisches von cis- und trans-Diamin-platin(II)-chlorid. Der zweite Schritt ist die Zersetzung des Diaminkomplexes zu metallischem Pt, H2, HCl und NH4Cl. Die Reduktion von Pt(II) zu metallischem Pt ist mit der Oxydation von Ammoniak zu molekularem Stickstoff und Protonen gekoppelt.
    Abstract: Резюме Совмещенные методы Т Г-, ДТГ-, ДТА-, АВГ- и масс-спектрометрии б ыли использованы для опр еделения путей разло жения тетрааминоплатина(II)х лорида и цис- и трансди аминоплатина(II)хлорид а. трансдиаминоплатин а(II)хлорида. Однозначная идентиф икация выделяющихся газов была проведена прямым введением про бы в масс-спектрометр. Термическое разложе ние (NH3)4PtCl2 протекает в две стади и. Первой стадией разл ожения является эндотермич еская потеря двух молей аммиака с образ ованием смеси цис- и транс-(NHN3)2PtCl2. Второй стад ией является разложение диаминов ого комплекса до мета ллической платины, азота, хлорис того водорода и хлористого аммония. В осстановление двухв алентной платины до металличе ской сопровождается окислением аммиака д о молекулярного азот а и протонов.
    Notes: Abstract Simultaneous thermogravimetry (TG), derivative thermogravimetry (DTG), differential thermal analysis (DTA), and evolved gas analysis (EGA) by mass spectrometry (MS) have been used to determine the decomposition path for tetraamineplatinum(II) chloride and cis- and trans-diamineplatinum(II) chloride. Unequivocal identification of the evolved gases was done by direct insertion probe mass spectrometry. The thermal decomposition of (NH3)4PtCl2 occurred in two steps. The first was endothermic loss of two moles of ammonia producing a mixture of cis- and trans-diaamineplatinum(II) chloride. The second step was decomposition of the diamine complex to metallic Pt and N2, HCl, and NH4Cl. Reduction of Pt(II) to metallic Pt was coupled with oxidation of ammonia to molecular nitrogen and protons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01913768
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