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  • 1
    Electronic Resource
    Electronic Resource
    Cystic fibrosis with three mutations in the cystic fibrosis transmembrane conductance regulator gene (1991)
    Springer
    Human genetics 〈Berlin〉 87 (1991), S. 441-446 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Three mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene were discovered in a pancreas-insufficient patient with cystic fibrosis (CF) who displayed an uncommon combination of almost normal chloride concentration in sweat tests and typical symptoms of gastrointestinal and pulmonary disease. The R553Q mutation was found on the maternal ΔF508-CFTR gene. Codon 553 is located within a consensus motif of the ATP-binding cassette transport proteins at a less conserved position. Other members of this protein superfamily contain a glutamine instead of arginine at the homologous position, suggesting a modulating rather than disease-causing role of the R553Q mutation in CFTR. The amplification refractory mutation system did not detect the R553Q mutation in a further 65 normal, 113 ΔF508, and 91 non-ΔF508 CF chromosomes. The index case carried the R553X nonsense mutation on the paternal chromosome. The R553X mutation was present on a further 9 out of 86 German nonΔF508 CF chromosomes linked with the XV2c-KM19Mp6d9-J44-GATT haplotypes 2-2-2-1-1 and 1-1-2-1-2. The location of R553X on separate haplotypes including both alleles of the intragenic GATT repeat suggests an ancient and/or multiple origins of the R553X mutations. The association of the genotype of the CFTR mutation and the clinical phenotype was assessed for the patients carrying the related genotypes ΔF508/ΔF508 (n = 80), ΔF508/R553X (n = 9) and ΔF508-R553Q/R553X (n = 1). In compound heterozygotes, the median chloride concentration in pilocarpine iontophoresis sweat tests was significantly lower than in the ΔF508 homozygotes (P 〈 0.01). The patient groups were significantly different with respect to the distributions of the centiles for height (P 〈 0.001) and weight (P 〈 0.01) as the most sensitive predictors of the course and prognosis in CF. Growth retardation was more pronounced in the compound heterozygotes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197165
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  • 2
    Electronic Resource
    Electronic Resource
    The potential of micromixers for contacting of disperse liquid phases (1999)
    Springer
    Fresenius' journal of analytical chemistry 364 (1999), S. 617-624 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The dispersion of two immiscible fluids in a static micromixer comprising interdigital channels with corrugated walls was investigated using silicon oil dispersed in dyed as well as pure water as test systems. Silicon oil and water flow rates between 20 mL/h to 500 mL/h and 150 mL/h to 700 mL/h were used, respectively. The experiments revealed the dependence of the average droplet size and size distribution on geometrical parameters of the micromixer and operating conditions. Dispersions with average droplet sizes as small as 5.6 μm and monomodal size distributions having small standard deviations of the droplet size down to 3.6 μm could be generated using the micromixer. The droplet size decreased with increasing total flow and ratio of the flow rates of the two liquids. In addition, a decrease of the droplet size was found when decreasing the channel width of the mixing device. Generally, the silicon oil – dyed water dispersion showed smaller average droplet sizes and were more stable compared to the dispersions based on silicon oil and pure water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160051397
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  • 3
    Electronic Resource
    Electronic Resource
    Application of Right Atrial Contiguous Linear Lesions: An In Vivo Efficacy Validation of Multipolar Ablation Catheters in an Animal Model (2002)
    Oxford, UK : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 25 (2002), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SCHNEIDER, M.A.E., et al.: Application of Right Atrial Contiguous Linear Lesions: An In Vivo Efficacy Validation of Multipolar Ablation Catheters in an Animal Model. Catheter ablation of atrial flutter and catheter Maze procedures require the creation of linear lesions. The efficacy of different multipolar catheters to create linear contiguous transmural lesions was studied in a sheep model. In 19 sheep a multipolar ablation catheter was inserted into the right atrium. In nine sheep a steerable 7 Fr catheter (C1) with six 6-mm electrodes and in five sheep a steerable 7 Fr catheter (C2) with four 5-mm electrodes were placed. In five sheep a 3.7 Fr catheter (C3) with eight electrodes of 6-mm length was deployed (steerable sheath). A total of 72 linear lesions were created and evaluated. Catheter types C1, C2, and C3 produced continuous lesions with at least two adjacent electrodes in 45%, 79%, and 87% of the lesions. The mean lesion length achieved by C3 was longer compared to C1 and C2 (27 ± 14 vs 10 ± 5 and 11 ± 6 mm; P 〈 0.05). The ability to produce contiguous lesions by all available electrodes was low: C1, 5%; C2, 5%; and C3, 6%. C3 was most effective in exerting transmural lesions (93% vs C1 75% and C2 57%; P 〈 0.0001). Microscopic endocardial fibrinous adhesions and macroscopic mild electrode carbonizations were caused by all catheter types. In conclusion, (1) all three catheter types do not create contiguous lesions along all electrodes. Gaps of viable tissue remain in most instances; (2) lesion depths and transmurality varies with different catheters; and (3) potentially hazardous thrombotic material was observed during radiofrequency ablation with all three catheters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.2002.01459.x
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  • 4
    Electronic Resource
    Electronic Resource
    Intraoperative Examination of Sentinel Lymph Nodes by Ultrarapid Immunohistochemistry (2003)
    Oxford, UK : Blackwell Science Inc
    The @breast journal 9 (2003), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The recently developed method of ultrarapid immunohistochemistry (IHC) was applied to the intraoperative examination of sentinel lymph nodes (SLNs) in breast cancer patients. In a prospective study of 50 patients with invasive breast carcinomas, a total of 60 SLNs were studied. Among them, 33 SLNs from 30 patients were studied intraoperatively using a direct immunoperoxidase method with anticytokeratin antibody clone MNF116. This technique has a turnaround time of less than 20 minutes Ultrarapid IHC revealed 15 positive SLNs compared to 14 positive SLNs using hematoxylin and eosin (H&E) frozen sections. The one SLN missed in H&E frozen sections presented with cytokeratin-positive isolated tumor cells in the lymph node sinus. After paraffin embedding, H&E-stained serial step sections of the SLN specimens detected another two patients with isolated tumor cells. We also examined the remaining axillary lymph nodes (ALNs) by H&E-stained serial step paraffin sections. From 17 of the 30 patients with positive SLNs, 6 patients also had metastatic involvement of the ALNs of level I or II. Thus ultrarapid IHC was a very sensitive and rapid technique for the intraoperative detection of metastatic involvement of SLNs in breast cancer patients. This technique may be a useful complementary tool for the intraoperative study of SLNs, particularly in tumors that are a diagnostic challenge, such as lobular carcinoma. 
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-4741.2003.09405.x
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  • 5
    Electronic Resource
    Electronic Resource
    Idiopathische Trommelschlegelfinger (1994)
    Springer
    Der Hautarzt 45 (1994), S. 866-870 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Trommelschlegelfinger – Paraneoplasie – Hypertrophe Osteoarthropathie – Pachydermoperiostose – Platelet-derived growth factor ; Key words: Clubbing – Paraneoplasia – Hypertrophic osteoarthropathy – Pachydermoperiostosis – Platelet-derived growth factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. We report on a patient with marked clubbing of the fingers and toes with watch-glass deformity of the nails, diagnosed as idiopathic clubbing. New findings on the pathogenesis of clubbing provide evidence for the important role of cytokines, especially platelet-derived growth factor and tumor necrosis factor-alpha. The differential diagnosis includes, besides rare primary forms, clubbing in malignant neoplasias and chronic inflammatory diseases of the heart, the lung, the upper gastrointestinal tract and the liver. Clubbing can precede other symptoms of neoplasias by months and could be dependent on a genetic predisposition.
    Notes: Zusammenfassung. Wir berichten über einen Patienten mit ausgeprägten Trommelschlegelfingern und -zehen mit Uhrglasnägeln, bei dem wir die Diagnose idiopathische Trommelschlegelfinger stellten. Neuere Vorstellungen zur Pathogenese der Trommelschlegelfinger gehen davon aus, daß Zytokine eine bedeutende Rolle spielen. Es werden v. a. der Platelet-derived growth factor (PDGF) und der Tumor Nekrose Faktor alpha (TNF-α) diskutiert. Die Differentialdiagnose der Trommelschlegelfinger beinhaltet neben den seltenen primären Formen v. a. die sekundäre Genese bei Neoplasien und chronisch-entzündlichen Erkrankungen des Herzens, der Lunge, des oberen Gastrointestinaltraktes und der Leber. Trommelschlegelfinger können anderen Symptomen von Neoplasien um Monate vorausgehen. Ihre Ausbildung bei einer bestehenden Grunderkrankung ist evtl. von einer genetischen Prädisposition beeinflußt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050188
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  • 6
    Electronic Resource
    Electronic Resource
    Genome-wide, large-scale production of mutant mice by ENU mutagenesis (2000)
    [s.l.] : Nature America Inc.
    Nature genetics 25 (2000), S. 444-447 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] In the post-genome era, the mouse will have a major role as a model system for functional genome analysis. This requires a large number of mutants similar to the collections available from other model organisms such as Drosophila melanogaster and Caenorhabditis elegans. Here we report on a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/78146
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  • 7
    Electronic Resource
    Electronic Resource
    What do we know about the non-uniform perception of a phototropic stimulus in Phycomyces? (1990)
    Springer
    Planta 182 (1990), S. 107-112 
    Details
    ISSN: 1432-2048
    Keywords: Lens effect (Phycomyces) ; Light stimulus (non-uniform) ; Phototropism (Phycomyces) ; Signal processing (spatial factors)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract For a comprehensive study of phototropism in sporangiophores of the fungus Phycomyces, quantitative treatment of spatial aspects is necessary. The first step in quantifying spatial factors of phototropic signal processing is the elucidation of the non-uniform light profile, predominantly caused by a lens effect in the cylindrical body of the sporangiophore. Herein we compare recently presented theoretical and experimental studies of light profiles. Errors and ambiguities arising from instrumental limitations and arbitrary assumptions are revealed. On the other hand, by combining theoretical and experimental results we have been able to select out the reliable information, which can now be applied in phototropic studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239991
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  • 8
    Electronic Resource
    Electronic Resource
    Managing Scientific Data: the EMAP Approach (1998)
    Springer
    Environmental monitoring and assessment 51 (1998), S. 429-440 
    Details
    ISSN: 1573-2959
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Many data sets used by EPA's Environmental Monitoring and Assessment Program (EMAP) will be collected and managed by groups other than EPA as the Committee on Environment and Natural Resources develops the inter-agency National Environmental Monitoring Initiative. Managing these data requires a change from a database managed solely by EPA to a model where there is, in addition to distributed databases, truly distributed ownership and responsibility. Common standards, data directories, and data descriptions allow data of interest to be located, understood, and downloaded. The level of EMAP data management practices applied to a data set is based on the degree of EMAP responsibility for the data. The EMAP Data Directory is an Oracle database that tracks data sets of interest and contains sufficient information about a data set for a user to determine if the data are of interest. Some of the data sets listed in the Directory are in the possession of EMAP and are accessible on the EMAP WWW site (http://www.epa.gov/emap). Other data sets in the Directory are managed, documented, and made available by other organizations. The Data Catalog contains metadata about data sets in the possession of EMAP and provides the user with information about methods, assumptions, and data quality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005901102034
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  • 9
    Electronic Resource
    Electronic Resource
    Anwendungspotentiale für chemische und biologische MikroreaktorenVortrag anläßlich der GVC-Jahrestagung, 25./27. September 1996 in Dortmund (1997)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 69 (1997), S. 931-934 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330690706
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of pressure on the α-amylase catalyzed hydrolysis of starch (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 6 (1964), S. 469-471 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: It was found that moderate pressures (16.0 to 43.1 atmospheres) perceptibly decreased the rate of α-amylase catalyzed starch hydrolysis. The decreased rate was apparently due to pressure induced deactivation of the enzyme.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260060408
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