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  • 1
    Electronic Resource
    Electronic Resource
    Purification, crystallization, and preliminary x-ray diffraction analysis of an M.HhaI-AdoMet complex (1992)
    s.l. : American Chemical Society
    Biochemistry 31 (1992), S. 8648-8653 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00151a035
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  • 2
    Electronic Resource
    Electronic Resource
    Forearm Blood Flow Responding Prior to Voluntary Isometric Contraction (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 21 (1984), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Srain-gauge plethysmography was used to study phasic forearm blood flow (FBF) responding, which has been presumed to occur in human subjects prior to voluntary muscular contraction. In a two-group design, 10 subjects performed a 7-s, fixed-foreperiod, reaction-time (RT) task in which static handgrip was the required RT response; 10 additional subjects in a High Incentive (HI) condition performed a more stressful delayed avoidance task. Bilateral FBF and HR were computer-sampled over the preparatory interval (PI) and transformed into second-by-second measures. Mean FBF estimates were also obtained by averaging over the entire PI. HI subjects were found to manifest significantly greater mean FBF prior tro motor responding than did subjects performing the nonstressful RT taks. Such preparatory FBF responding was task-specific, occurring only in the Arm to be performing the signalled RT response. Furthermore, this task-specific, phasic increase in averaged mean FBF was observed to occur in subjects' left and right arms. Trend analysis and visual inspection of second-by-second FBF waveforms demonstrated a gradual decline in flow rate over the course of the preparatory interval under all experimental conditions. HR responding manifested the characteristic triphasic waveforms, with higher heart rate and augmentation of acceleratory and terminal deceleratory components exhibited by the HI group. the findings suggest that human phasic FBF responding can be influenced by motoric and motivational factors as well as by demands for sensory intake behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1984.tb00213.x
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  • 3
    Electronic Resource
    Electronic Resource
    Save your notes, drafts and printouts: today's work is tomorrow's history (2007)
    [s.l.] : Nature Publishing Group
    Nature 446 (2007), S. 725-725 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir Science is one of the greatest cultural achievements of humankind. And yet — although we assiduously preserve the preparatory sketches of artists, the drafts of novelists and the manuscript scores of composers — there is little systematic preservation of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/446725a
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Recognition sequence of specific endonuclease Bam HI from Bacillus amyloliquefaciens H (1977)
    [s.l.] : Nature Publishing Group
    Nature 265 (1977), S. 82-84 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The BamHI used for these experiments was purified and used as described previously2. This endonuclease gives relatively few fragments from most viral DNAs and, to ensure a statistically significant sampling, parallel experiments were carried out on bacteriophage l DNA (five sites)2, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/265082a0
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  • 5
    Electronic Resource
    Electronic Resource
    Libya should stop denying scientific evidence on HIV (2007)
    [s.l.] : Nature Publishing Group
    Nature 448 (2007), S. 992-992 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir We welcome Libya's recent decision to commute to life imprisonment the death sentences of five Bulgarian nurses and a Palestinian medic. All six were imprisoned for eight years on false charges of deliberately infecting children with HIV in the hospital where they worked. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/448992a
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  • 6
    Electronic Resource
    Electronic Resource
    An open letter to Colonel Muammar al-Gaddafi (2006)
    [s.l.] : Nature Publishing Group
    Nature 444 (2006), S. 146-146 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Dear Colonel Muammar al-Gaddafi We, Nobel Laureates in the sciences, are gravely concerned about the ongoing trial of five Bulgarian nurses, Valya Chervenyashka, Snezhana Dimitrova, Nasya Nenova, Valentina Siropulo, Kristiana Valcheva, and a Palestinian doctor, Ashraf Ahmad ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/444146a
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  • 7
    Electronic Resource
    Electronic Resource
    BASE FLIPPING (1998)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 67 (1998), S. 181-198 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Abstract Base flipping is the phenomenon whereby a base in normal B-DNA is swung completely out of the helix into an extrahelical position. It was discovered in 1994 when the first co-crystal structure was reported for a cytosine-5 DNA methyltransferase binding to DNA. Since then it has been shown to occur in many systems where enzymes need access to a DNA base to perform chemistry on it. Many DNA glycosylases that remove abnormal bases from DNA use this mechanism. This review describes systems known to use base flipping as well as many systems where it is likely to occur but has not yet been rigorously demonstrated. The mechanism and evolution of base flipping are also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biochem.67.1.181
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  • 8
    Electronic Resource
    Electronic Resource
    Structures of Hha I methyltransferase complexed with substrates containing mismatches at the target base (1998)
    [s.l.] : Nature America Inc.
    Nature structural biology 5 (1998), S. 872-877 
    Details
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Three structures have been determined for complexes between HhaI methyltransferase (M.HhaI) and oligonucleotides containing a G:A, G:U or G:AP (AP = abasic or apurinic/apyrimidinic) mismatch at the target base pair. The mismatched adenine, uracil and abasic site are all flipped out of the DNA ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2312
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  • 9
    Electronic Resource
    Electronic Resource
    Intervening sequences excised in vitro (1978)
    [s.l.] : Nature Publishing Group
    Nature 274 (1978), S. 530-530 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SINCE the initial discovery of bizarre happenings during eukaryotic mRNA biosynthesis there has been considerable discussion of the mechanism by which intervening sequences are removed. The bulk of circumstantial evidence pointed to a mechanism which operates on an initial RNA transcript containing ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/274530a0
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Restriction endonucleases: a new role in vivo? (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 502-502 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] FEW enzymes have been exploited as thoroughly as the bacterial restriction enzymes. In recent years they have been instrumental in dramatic advances in DNA sequence analysis, genetic engineering, and studies of gene structure and function. Yet surprisingly little is known of their biological role. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/271502a0
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