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  • 1
    Digitale Medien
    Digitale Medien
    Serum Inhibitory Factor in Lepromatous Leprosy: Its Effect on the Pre-S-Phase Cell-Cycle Kinetics of Mitogen-stimulated Normal Human Lymphocytes (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 14 (1981), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The sera of ten Egyptian men with long-standing lepromatous leprosy (LL) (mean duration 17.4 years) that had failed to respond in dapsone treatment were shown to inhibit mitogen stimulation responses of normal human lymphocytes. When first tested, the sera partly inhibited the response to phytohaemagglutinin (PHA) and pokeweed mitogen and virtually abolished that to concanavalin A (Con A): after repeated freezing and thawing, the Con A inhibition had disappeared, whereas the PHA response was still partly Inhibited. The inhibitory serum factor(s) had similar actions on lymphocytes from each of six normal donors. Although the sera varied in potency, they showed similar dose response curves when tested against lymphocytes from a single donor. The principal action of the sera was to reduce the number of cells responding to mitogen, without modifying the kinetics of recruitment or rate of volume growth during G1-phase in those cells that were unaffected by the inhibitory substances(s). Study of PHA dose-response curves and of the effect of delayed addition of LL serum suggested that the serum factor(s) act by diminishing the responsiveness of the cells, rather than by reducing the concentrations of free mitogen or by blocking cell membrane mitogen receptors The serum from one apparently healthy attendant, who had nursed leprosy patients for 30 years but who did not have leprosy or other chronic infective disease, inhibited completely stimulation by all three mitogens in a manner different from that of LL sera. Serum from the other 13 control patients did not modify the response of normal lymphocytes to stimulation by any of the three mitogens studied. It was concluded that the inhibitory factor(s) in the scrum of patients, with LL were a consequence of the disease and not of the environment in which the patients lived. Microscopy confirmed that the techniques used for recovery of the cultured cells did not introduce bias into the volume spectroscopy measurements.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.1981.tb00564.x
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  • 2
    Digitale Medien
    Digitale Medien
    The study of the process of fluid-phase endocytosis in cervical squamous cells using fluorescent microspheres (1999)
    Oxford, UK : Blackwell Science Ltd
    Cytopathology 10 (1999), S. 0 
    Details
    ISSN: 1365-2303
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Physiological processes in cervical squamous epithelium have not been extensively studied. Perhaps understandably, most of the research has concentrated on the pathology of the cervix, in particular dysplasia and malignancy. Fluid-phase endocytosis is a physiological process which has been demonstrated to be important in understanding disease development at other squamous epithelial sites, e.g. oesophagus. In this study, we have demonstrated by a new methodology developed in our laboratory using fluorescent microspheres and flow cytometry that fluid-phase endocytosis occurs in cervical squamous cells. The process has been shown to be dose- and time-dependent. This novel approach provides a means to improve our understanding of the physiological functions of the cervix and may provide insight into the pathogenesis of cervical neoplastic and non-neoplastic disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2303.1999.00209.x
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  • 3
    Digitale Medien
    Digitale Medien
    Malignant granular cell tumour (myoblastoma) of the vulva: report of a case and review of the literature (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 5 (1981), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A case of malignant granular cell tumour (myoblastoma) which metastasized from the vulva to the regional lymph nodes is presented. Electron microscopy of the metastases demonstrated the presence of numerous intra-cytoplasmic lysosomes, a feature characteristic of these neoplasms, and the neoplasm was shown to stain strongly for carcinoembryonic antigen (CEA) using the immunoperoxidase technique. Previous reports in the literature of malignant granular cell tumours are reviewed and discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1981.tb01768.x
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  • 4
    Digitale Medien
    Digitale Medien
    Angiolymphoid hyperplasia with eosinophilia: report of a case arising from the radial artery (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 11 (1987), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A case of angiolymphoid hyperplasia with eosinophilia arising from the radial artery is presented. Histologically, there was proliferation of atypical endothelial cells forming vascular spaces and solid cords, with a background infiltrate of inflammatory cells and prominent tissue eosinophilia. Immunohistochemical studies demonstrated vimentin and factor VIII related antigen in the endothelial cells. The lymphoid infiltrate was polyclonal. These lesions, which typically occur in the dermis and subcutaneous tissue of the head and neck, are known by a variety of different names reflecting disagreement regarding their pathogenesis. The probable nature of the process is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1987.tb01902.x
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  • 5
    Digitale Medien
    Digitale Medien
    Consistency of histopathological reporting of laryngeal dysplasia (2000)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 37 (2000), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: AimsClinical management of premalignant and malignant lesions of the larynx is dependent on histopathological evaluation. The Scottish Pathology Consistency Group assessed interobserver variation in the evaluation of laryngeal dysplasia.Methods and resultsOne hundred laryngeal biopsies ranging from normal to invasive carcinoma were assessed. The overall Kappa result of 0.32 was disappointing. However, agreement on those categories which dictate significantly different management was more favourable. The Kappa figure for mild dysplasia versus severe dysplasia/CIS was 0.7, the Kappa figure for mild dysplasia versus severe dysplasia/CIS and invasive carcinoma was 0.77. The Kappa figure for mild and moderate dysplasia versus severe dysplasia/CIS and invasive carcinoma was 0.57. An attempt to use a two grade system gave a Kappa figure of 0.52.ConclusionsOur group had a satisfactory agreement on the distinction of mild from severe dysplasia and on microinvasive carcinoma without any discussion as to histopathological criteria to be used. Clinical management — review endoscopy, repeat cord stripping, radiotherapy and laryngectomy — is in general dependent on histological assessment. Thus the agreement on categories which underpin clinical management is reassuring. However, assessment of moderate dysplasia remains problematic. An attempt to utilize a two grade system — low grade from high grade dysplasia/CIS — may have merit. The implications of the terminology used must be agreed among pathologists and clinicians working closely within clinicopathological cancer groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2559.2000.00998.x
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  • 6
    Digitale Medien
    Digitale Medien
    Observer variability in the Goseki grouping of gastric adenocarcinoma in resection and biopsy specimens (2003)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 42 (2003), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Aims:  The Goseki grouping of gastric adenocarcinoma has been suggested as a possible prognostic factor. In those centres where it is used, it may be valuable to assess the Goseki grouping of a tumour on the initial diagnostic biopsy as well as on the resection specimen since it may in theory influence management. We examined the robustness of Goseki grouping of gastric adenocarcinoma in representative sections from resection and biopsy specimens in order to assess the consistency of agreement among a group of pathologists.Methods:  A single representative block from 100 gastric resection specimens was studied using a haematoxylin and eosin and mucin (alcian blue/periodic acid–Schiff) stain. These were circulated in batches to members of a group of 12 pathologists who each completed a simple proforma confirming the presence of carcinoma and assigning a Goseki group. In a second circulation the diagnostic biopsy specimen taken prior to resection was examined in the same way. This allowed comparison of the Goseki group of the biopsy and resection specimens.Results:  In both studies κ statistics showed good agreement on tubular differentiation of the carcinoma, but only moderate agreement for the intracellular mucin production, resulting in moderate agreement for the final Goseki group. Correlation between the Goseki group assigned on the biopsy and resected specimens was seen in 62% of the cases. However, the reproducibility was low (κ 0.375).Conclusions:  The Goseki grouping of resected gastric adenocarcinoma is reproducible and can be used in prognostication. Goseki grouping of biopsy specimens is of limited value in predicting the Goseki group assigned to the resected carcinoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2559.2003.01609.x
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  • 7
    Digitale Medien
    Digitale Medien
    Gases Liberated from Explosions Initiated by Impact (1948)
    [s.l.] : Nature Publishing Group
    Nature 161 (1948), S. 806-807 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] TRUE detonation in high explosives normally gives as the major products gases such as carbon dioxide and monoxide, water, nitrogen and hydrogen1,2, the relative quantities obtained being in general accordance with calculations based on equilibrium considerations. The thermal ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/161806a0
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  • 8
    Digitale Medien
    Digitale Medien
    High viscosity vesicles of yeast separated at p H 4 have surface glycoprotein (1978)
    [s.l.] : Nature Publishing Group
    Nature 273 (1978), S. 682-684 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] We used the procedure described by Fuhrmann et al.2 for the isolation of plasma membrane vesicles capable of galactose transport. A 5,000g pellet from mechanically disrupted cells was resuspended at 1 mg protein ml"1 in ice cold osmotic stabiliser (400mMKCl, lmMMgCl2, 20 mM tri-ethanolamine). The ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/273682a0
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  • 9
    Digitale Medien
    Digitale Medien
    Laparoscopic cholecystectomy injury: an unusual indication for liver transplantation (1998)
    Springer
    Transplant international 11 (1998), S. 449-451 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Key words Laparoscopic cholecystectomy ; bile duct injury ; liver transplantation ; Bile duct injury ; laparoscopic cholecystectomy ; liver transplantation ; Liver transplantation ; laparoscopic cholecystectomy ; bile duct injury
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The introduction of laparoscopic cholecystectomy has been associated with a rise in the number of reported bile duct injuries (0.3 %–0.8 %). Significant vascular injuries are rare (0.16 %), but may lead to life-threatening complications. We present a case report of a patient undergoing transplantion for a laparoscopic cholecystectomy injury.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001470050173
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  • 10
    Digitale Medien
    Digitale Medien
    Splenic artery aneurysm and orthotopic liver transplantation (1999)
    Springer
    Transplant international 12 (1999), S. 68-70 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Key words Liver transplantation ; splenic artery aneurysm ; Splenic artery aneurysm ; liver transplantation ; Portal hypertension ; splenic artery aneurysm ; Alpha-1-antitrypsin deficiency ; splenic artery aneurysm
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Splenic artery aneurysms are a rare but potentially fatal complication after liver transplantation. We report three cases presenting in a 12-month period in adult patients who underwent transplantation for chronic liver disease. Doppler ultrasound of the splenic artery should be performed in all patients with cirrhosis and portal hypertension who are being assessed for liver transplantation. The aneurysm can be ligated at the time of transplantation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001470050187
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