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  • 1
    Electronic Resource
    Electronic Resource
    Regulation of gonadotropin-stimulable adenylyl cyclase of the primate corpus luteum
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 32 (1989), S. 175-182 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(89)90161-1
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  • 2
    Electronic Resource
    Electronic Resource
    The role of the adenylyl cydase system in the regulation of corpus luteum function in the human and in nonhuman primates
    Amsterdam : Elsevier
    Steroids 56 (1991), S. 252-257 
    Details
    ISSN: 0039-128X
    Keywords: adenylyl cyclase ; corpus luteum ; gonadotropins ; isoproterenol ; menstrual cycle ; pregnancy ; progesterone secretion ; prostaglandin E"2
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0039-128X(91)90043-U
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  • 3
    Electronic Resource
    Electronic Resource
    Increased mast cell density and protease content in actinic cheilitis (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of oral pathology & medicine 33 (2004), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Actinic cheilitis (AC) is a pre-malignant lesion caused by ultraviolet (UV) radiation and characterized by epithelial and connective tissue alterations. Mast cells (MCs), key contributors to solar elastosis in murine UV-irradiated skin, were characterized in order to assess their potential contribution to connective tissue degeneration in AC.Methods:  Actinic cheilitis (n = 15) and normal lip (n = 8) biopsies were stained immunohistochemically for tryptase and enzymehistochemically for chymase to determine MC density and protease content. MC subpopulations (i.e. MCT containing only tryptase, and MCTC containing chymase and tryptase) and their distribution were also determined.Results:  Mast cells and their proteases were increased in AC as compared with normal lip (P 〈 0.0001), and appeared degranulated especially around elastotic areas. MCT predominated over MCTC in AC and normal lip (P 〈 0.05). However, in AC MCT were increased in the epithelium/connective junction and connective area (P 〈 0.05), while in normal lip MCT predominated in connective and submucosal areas (P 〈 0.05).Conclusion:  The results suggest that increased MC density and protease content may contribute to elastosis formation in AC. In addition, changes in MCT distribution may favor AC malignization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.2004.00242.x
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of mast cell subpopulations in lip cancer (2005)
    Oxford, UK : Munksgaard International Publishers
    Journal of oral pathology & medicine 34 (2005), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Lip squamous cell carcinoma (SCC) is the most common form of oral cancer. Human mast cells (MCs), which are increased in lip SCC, are classified by their protease content in tryptase-positive (MCT) and tryptase/chymase-positive (MCTC). MC proteases are associated with tumor progression and angiogenesis. The aim of this study was to quantify and characterize MC subpopulations in lip SCC.Methods:  Serial sections from lip SCC (n = 21) and normal lip vermilion (n = 8) biopsies were stained immunohistochemically for tryptase and enzymehistochemically for chymase to determine MC subpopulation density and distribution.Results:  MCT and MCTC were increased in lip SCC when compared with normal lip (P 〈 0.0001), where MCT predominated over MCTC (P 〈 0.01). In lip SCC neither subpopulation predominated. Regarding distribution, MCT were higher than MCTC at the intratumoral stroma, whereas MCTC were higher than MCT at the peritumoral stroma (P 〈 0.01).Conclusions:  The results suggest that MC subpopulations may contribute to lip SCC progression. While intratumoral MCT may stimulate angiogenesis, peritumoral MCTC may promote extracellular matrix degradation and tumor progression at the invasion front.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.2004.00297.x
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  • 5
    Electronic Resource
    Electronic Resource
    Expression of apoptotic and cell proliferation regulatory proteins in actinic cheilitis (2005)
    Oxford, UK : Munksgaard International Publishers
    Journal of oral pathology & medicine 34 (2005), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Actinic cheilitis (AC) is a pre-malignant lesion caused by ultraviolet (UV) radiation. The apoptotic proteins p53, bax, bcl-2, and the proliferation marker Ki-67, are known to play an important role in UV-exposed skin and carcinomas, therefore, these markers were assessed in AC and compared with normal lip and oral mucosa.Methods:  AC (n = 13), normal lip (n = 7) and oral mucosa (n = 6) biopsies were stained immunohistochemically for p53, bax, bcl-2 and Ki-67, to determine their expression and distribution.Results:  p53 was over-expressed in AC as compared with normal lip and oral mucosa (P 〈 0.003). Although bcl-2 expression was higher in AC than in oral mucosa (P 〈 0.002), it was significantly reduced as compared with normal lip (P 〈 0.04). Bax expression remained unchanged, and Ki-67 was significantly increased in AC and normal lip as compared with oral mucosa (P 〈 0.05).Conclusion:  The results suggest that DNA-damaged cells by UV radiation in AC are eliminated by apoptosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.2004.00299.x
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  • 6
    Electronic Resource
    Electronic Resource
    Competitive and Temporal Inhibition Structures with Spiking Neurons (2000)
    Springer
    Neural processing letters 11 (2000), S. 197-208 
    Details
    ISSN: 1573-773X
    Keywords: spiking neurons ; competitive processing ; temporal inhibition ; attentional control mechanisms ; bio-inspired neural systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The paper describes the implementation of competitive neural structures based on a spiking neural model that includes multiplicative or shunting synapses enabling non-saturated stable states in response to different stationary inputs as well as controllable transient responses. A VLSI-viable implementation of this model has been previously proposed and tested [1]. It has the possibility of modulating the output spike frequency by an additional input without affecting other neuron variables such as the membrane potential. This feature is exploited in the simulation of a Selective Temporal Inhibition network that is suitable for implementing attentional control systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009611609606
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  • 7
    Electronic Resource
    Electronic Resource
    Obtaining Fault Tolerant Multilayer Perceptrons Using an Explicit Regularization (2000)
    Springer
    Neural processing letters 12 (2000), S. 107-113 
    Details
    ISSN: 1573-773X
    Keywords: backpropagation ; regularization ; multilayer perceptron ; fault tolerance ; mean square sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract When the learning algorithm is applied to a MLP structure, different solutions for the weight values can be obtained if the parameters of the applied rule or the initial conditions are changed. Those solutions can present similar performance with respect to learning, but they differ in other aspects, in particular, fault tolerance against weight perturbations. In this paper, a backpropagation algorithm that maximizes fault tolerance is proposed. The algorithm presented explicitly adds a new term to the backpropagation learning rule related to the mean square error degradation in the presence of weight deviations in order to minimize this degradation. The results obtained demonstrate the efficiency of the learning rule proposed here in comparison with other algorithm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009698206772
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  • 8
    Electronic Resource
    Electronic Resource
    Chemical characterization of recombinant human epidermal growth factor
    Amsterdam : Elsevier
    Analytica Chimica Acta 239 (1990), S. 301-305 
    Details
    ISSN: 0003-2670
    Keywords: Recombinant human epidermal growth factor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(00)83866-0
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  • 9
    Electronic Resource
    Electronic Resource
    An Accurate Measure for Multilayer Perceptron Tolerance to Weight Deviations (1999)
    Springer
    Neural processing letters 10 (1999), S. 121-130 
    Details
    ISSN: 1573-773X
    Keywords: mean square error degradation ; multilayer perceptron ; fault tolerance ; statistical sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The inherent fault tolerance of artificial neural networks (ANNs) is usually assumed, but several authors have claimed that ANNs are not always fault tolerant and have demonstrated the need to evaluate their robustness by quantitative measures. For this purpose, various alternatives have been proposed. In this paper we show the direct relation between the mean square error (MSE) and the statistical sensitivity to weight deviations, defining a measure of tolerance based on statistical sentitivity that we have called Mean Square Sensitivity (MSS); this allows us to predict accurately the degradation of the MSE when the weight values change and so constitutes a useful parameter for choosing between different configurations of MLPs. The experimental results obtained for different MLPs are shown and demonstrate the validity of our model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018733418248
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  • 10
    Electronic Resource
    Electronic Resource
    Analysis of the Functional Block Involved in the Design of Radial Basis Function Networks (2000)
    Springer
    Neural processing letters 12 (2000), S. 1-17 
    Details
    ISSN: 1573-773X
    Keywords: RBF neural networks ; neural networks design ; statistical analysis of RBF ; RBF structures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The main architectures, learning abilities and applications of radial basis function (RBF) neural networks are well documented. However, to the best of our knowledge, no in-depth analyses have been carried out into the influence on the behaviour of the neural network arising from the use of different alternatives for the design of an RBF (different non-linear functions, distances, number of neurons, structures, etc.). Thus, as a complement to the existing intuitive knowledge, it is necessary to have a more precise understanding of the significance of the different alternatives. In the present contribution, the relevance and relative importance of the parameters involved in such a design are investigated by using a statistical tool, the ANalysis Of the VAriance (ANOVA). In order to obtain results that are widely applicable, various problems of classification, functional approximation and time series estimation are analyzed. Conclusions are drawn regarding the whole set.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009621931185
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