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  • 1
    Electronic Resource
    Electronic Resource
    Effects of ventilation in ventral decubitus position on respiratory mechanics in adult respiratory distress syndrome (1997)
    Springer
    Intensive care medicine 23 (1997), S. 1219-1224 
    Details
    ISSN: 1432-1238
    Keywords: Key words Acute respiratory failure ; Gas exchange ; Mechanics ; Body position ; Compliance of respiratory system ; Mechanical ventilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To assess the potential benefits of a period of ventilation in ventral decubitus (VD) on oxygenation and respiratory mechanics in the adult respiratory distress syndrome (ARDS). Design: In a stable condition during baseline ventilation in dorsal decubitus (DD), after 15 min of ventilation in VD and after 10 min of restored DD, the following parameters were studied: arterial blood gas tension, haemodynamics and static respiratory compliance (Crs), evaluated with the rapid airway occlusion technique. Setting: The study was completed in the intensive care units of university hospitals as part of the management of the patients studied. Patients: Twelve patients (7 males, 5 females, mean age 51.8 ± 16.6 years) suffering from ARDS of different aetiologies. Interventions: Before and during each evaluation, the patients were kept under stable haemodynamic and metabolic conditions. The ventilatory setting was kept constant. All the patients were sedated, paralysed and mechanically ventilated. Results: A statistically significant increase in the ratio between the arterial partial pressure of oxygen and fractional inspired oxygen (p 〈 0.01) was observed between the baseline conditions (mean 123.9 ± 22.6) and VD (mean 153.0 ± 16.9), while no statistical significance was noted between baseline conditions and after 10 min of restored DD (mean 141.1 ± 19.7). A significant increase in Crs (p 〈 0.001) was observed between baseline conditions (mean 42 ± 10.1) and VD (mean 48.8 ± 9.6) and between baseline conditions and restored DD (mean 44.7 ± 10.6). Two patients were considered non-responders. All the patients were haemodynamically stable. No side effects were noted. Conclusions: We observed an increase in oxygenation and Crs when the patients were turned from the supine to the prone position with the upper thorax and pelvis supported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050489
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  • 2
    Electronic Resource
    Electronic Resource
    Immunological parameters in patients with frequently recurring genital herpes and response to treatment with a combination of acyclovir and interferon-β (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 1 (1992), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunologic status of 33 patients with frequently recurring genital herpes (FRGH) and the effect of two different antiviral regimens have been studied. Patients were treated with oral acyclovir capsules, 200 mg 4 times per day for 6 months (group A), or with a combination of oral acyclovir, 200 mg twice per day for 6 months, and intramuscular interferon-β (IFN-β), 3 MU daily for 10 days at every disease recurrence (group B). Before treatment, several immunologic abnormalities involving T and B lymphocytes, as well as cytotoxic (NK/K) cells, were observed in all patients. Clinical results confirmed the previously reported efficacy and safety of acyclovir for suppression of episodes of genital herpes. The acyclovir efficacy was enhanced by combination with IFN-β, which has antiviral and immunomodulatory properties. In our patients with FRGH and cell-mediated immunity impairment, IFN-β was able to restore, in part, the host immune deficit with a significant reduction in the number of recurrence of genital herpes episodes (recurrence rate of 19% in group B vs 47% in group A). No significant toxic effects were detected in either therapeutic regimes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1992.tb00636.x
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  • 3
    Electronic Resource
    Electronic Resource
    Chlamydia pneumoniae infections prevent the programmed cell death on THP-1 cell line (2002)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 215 (2002), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Chlamydia pneumoniae is an obligate intracellular bacterium which frequently causes airway infection in humans and has been implicated in chronic inflammatory disease and atherosclerosis. Here we show that infection with C. pneumoniae protects THP-1 cells against the apoptosis which spontaneously occurs in macrophages in the absence of an activation signal. Analysis by flow cytometry at different post-infection times revealed that 50±7% of THP-1 cells were apoptotic at 48 h after onset of the experiments, whereas C. pneumoniae-infected cultures (multiplicity of infection, MOI = 30) displayed only 18±4% of cells in apoptosis. At MOI = 20 and MOI = 10 the cells susceptible to apoptosis at 48 h were 28±5% and 35±6% respectively. Moreover, the results show that heat-inactivated bacteria do not give significant protection against apoptosis, even at higher MOI (MOI = 30), while UV-treated Chlamydia did provide a degree of protection against apoptosis. These data suggest that the anti-apoptotic effect of C. pneumoniae requires a heat-labile component released during infection, and that the effect is not lipopolysaccharide-dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2002.tb11372.x
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  • 4
    Electronic Resource
    Electronic Resource
    Novel approach to the ring-opening of 4-isoxazolines: One-pot synthesis of α,β-enones
    Amsterdam : Elsevier
    Tetrahedron 48 (1992), S. 123-132 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4020(01)80585-8
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of Taxol on TNF-α and IL-6 Production by Human Peripheral Blood Cells (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 784 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb16275.x
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  • 6
    Electronic Resource
    Electronic Resource
    Application of a computerised method to measure static pressure volume curve in acute respiratory distress syndrome (2000)
    Springer
    Intensive care medicine 26 (2000), S. 11-14 
    Details
    ISSN: 1432-1238
    Keywords: Key words Acute respiratory distress syndrome ; Static pressure volume curve ; Static compliance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To assess the safety and the bedside feasibility of a new computerised method to record the static pressure-volume curves (Pst/V) of the respiratory system.¶Design: The Pst/V curves were recorded in 13 medical patients with the acute respiratory distress syndrome (ARDS). During the Pst/V curve tracing the following parameters were recorded: time required for the recording and the automatic analysis of the Pst/V curve and modifications in electrocardiograms, blood pressure, and arterial oxygen satmation (SaO2).¶Setting: The study was performed in the intensive care unit of the University of Naples “Federico II”.¶Results: No statistically significant modifications in heart rate (HR, b min–1), blood pressure (BP, mmHg), and SaO2 were observed between conditions at baseline (HR 97.2 ± 17.7; BP 65.4 ± 9.3; SaO2 93.6 ± 2.0), during the recording (HR 99.8 ± 19.5; BP 66.2 ± 11.6; SaO2 93.7 ± 2.4), and 2 min after the procedure (HR 98.2 ± 17.8; BP 65.2 ± 11.7; SaO2 93.7 ± 1.9). The Pst/V curves were recorded in 8.38 ± 1.19 min and fully analysed in 2.69 ± 0.85 min. Mean value of static compliance was 41.1 ± 12.7 ml cmH2O–1. A lower inflection point was found in ten patients (mean value 9.2 ± 1.9 cmH2O).¶Conclusions: In ARDS patients, the present new computerised method gave valuable data to ordinary intensivists and was shown to be safe, easy, and fast.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050005
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  • 7
    Electronic Resource
    Electronic Resource
    Lipoteichoic acid and protein-A from Staphylococcus aureus stimulate release of hepatocyte growth factor (HGF) by human dermal fibroblasts (1998)
    Springer
    Archives of dermatological research 290 (1998), S. 211-214 
    Details
    ISSN: 1432-069X
    Keywords: Key words Dermal fibroblasts ; HGF ; Bacterial ; components
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study we demonstrated that Staphylococcus aureus lipoteichoic acid (LTA) and protein-A (PA) induce the release from human dermal fibroblasts of hepatocyte growth factor (HGF), a proliferation factor of epithelial cells (including keratinocytes). In contrast, LPS and porins from Pseudomonas aeruginosa did not stimulate HGF production. Recombinant human IL-1β induced HGF release. This production was synergistically enhanced when in association with LTA (by more than twice) and PA (by about two-thirds). Controls were performed in the presence of bacterial components alone. In previous studies we have shown that LPS and porins are inducers of IL-1α and β and other cytokines from human monocytes. Therefore it is possible that in inflammatory cutaneous foci and infected wounds, bacterial components may induce HGF release from dermal human fibroblasts. LTA and PA act directly, while LPS and porins act indirectly, through the release of cytokines by monocytes/macrophages. HGF plays an important role in the repair of cutaneous tissue during gram-positive and gram-negative infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050292
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