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  • 1
    Electronic Resource
    Electronic Resource
    ACUTE AND CHRONIC PHARMACOKINETIC STUDIES OF SLOW RELEASE KETOPROFEN (ORUVAIL) IN RHEUMATOID ARTHRITIS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Slow release preparations of non-steroidal anti-inflammatory drugs are used to simplify dose regimes in the treatment of rheumatoid arthritis with the aim of improving patients compliance. This study examines the acute and chronic pharmacokinetics of slow release ketoprofen in 13 rheumatoid patients with a mean age of 59.8 years.2. Pharmacokinetic parameters following the first dose including Tmax which was 6.92 h (s.e.m. = 0.80), Cmax 3.87 μg/ml (s.e.m. = 0.54), apparent half-life 8.8 h (s.e.m. = 1.0) and AUC 41.92 μg.h/ml (s.e.m. = 4.02) were not significantly different from those following the last dose after 3 months of chronic treatment, when these were Tmax 6.38 h (s.e.m. = 0.84) Cmax 3.57 μg/ml (s.e.m. = 0.33) apparent half-life 8.8 h (s.e.m. = 1.1) and AUC 43.18 μg.h/ml (s.e.m. = 5.34) respectively. These results show that no accumulation of ketoprofen occurred with chronic treatment.3. Clinical assessments were performed in an open design and showed significant improvement in pain, articular index, grip strength and duration of morning stiffness when these parameters were compared to treatment with paracetamol during an initial washout. The drug was well tolerated although there was a trend for the haemoglobin to fall and this parameter should be monitored during therapy with ketoprofen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb00938.x
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  • 2
    Electronic Resource
    Electronic Resource
    The EMLA patch—a new type of local anaesthetic application for dermal analgesia in children (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 49 (1994), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The skin application of EMLA cream under a Tegaderm dressing was compared in children with a new combined dressing/local anaesthetic patch—the EMLA patch. The analgesic effect during venepuncture was assessed using a visual analogue scale (patients) and a verbal rating scale (investigator). Skin adhesiveness and incidence of local skin reactions with the two types of application were also studied. The study was designed as an open randomised trial with two parallel groups. Sixty children, aged between 5 and 15 years were evaluated. After a minimum application time of 60 min an intravenous cannula was inserted. There was no difference in analgesia as assessed by the patients or the investigators. Mild discomfort at removal of the occlusive dressing/patch was observed in a few patients, but there was no difference in the adhesiveness of the Tegaderm dressing and the EMLA patch. Only mild local skin reactions (with paleness in the anaesthetised skin area) were observed in both groups. It was concluded that both the EMLA patch and the Tegaderm/EMLA cream dressing provide effective dermal analgesia for venepuncture with a 0.8 mm (outer diameter) cannula. The two types of application were indistinguishable but the ease of application of the patch is a distinct advantage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1994.tb03319.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of increased ventilation and improved pulmonary gas-exchange on maximal oxygen uptake and power output (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of medicine & science in sports 3 (1993), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: Recent reports suggest that aerobic performance at very high levels may be limited by the pulmonary system. The purpose of the present study was to compare respiratory functions at rest and during graded maximal aerobic exercise (cycle ergometry) between well-trained (TR, n= 11) and untrained (UT, n= 14) individuals while breathing atmospheric air, normoxic helium (He) and oxygen-enriched mixture. When the subjects breathed air, TR exhibited lower exercise ventilatory reserve (MVV-VEmax), ratio between minute ventilation (VE) and oxygen uptake (Vo2) and SaO2 than UT. Breathing HE resulted in an increase in VE and Vo2max in both groups but in an increased VE/Vo2 and SaO2 and maximal mechanical cycle ergometer load, only in TR. Compared with air, breathing an oxygen-enriched mixture resulted in increased peak exercise SaO2 and maximal mechanical load in both groups. It is concluded that arterial O2 desaturation secondary to a relative hypoventilatory response may limit Vo2max and aerobic performance capacity at high work levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0838.1993.tb00367.x
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  • 4
    Electronic Resource
    Electronic Resource
    The structure determination of two new acylphloroglucinols from Myrtus communis L.
    Amsterdam : Elsevier
    Tetrahedron 30 (1974), S. 991-997 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4020(01)97486-1
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  • 5
    Electronic Resource
    Electronic Resource
    The effects of negative air ions on various physiological functions during work in a hot environment (1982)
    Springer
    International journal of biometeorology 26 (1982), S. 153-163 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract The effects of negative air-ions on human physical performance has been investigated. Twenty-one healthy males, 20–25 years old (X=23.6±2.6) were exposed to two 180-min rest and exercise sessions two weeks apart. The subjects were randomly assigned into either an experimental group (n=12) or to a control group (n=9). The experimental group performed the first session in neutral air conditions and the second one in air containing 1.36 to 1.90×105 negative air ions and 1.40 to 1.66×102 positive air ions/ml. The control group performed both sessions under neutral air conditions. All sessions were held at Ta=40±1
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02184628
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  • 6
    Electronic Resource
    Electronic Resource
    Relationships of marathon running to physiological, anthropometric and training indices (1983)
    Springer
    European journal of applied physiology 51 (1983), S. 281-293 
    Details
    ISSN: 1439-6327
    Keywords: Marathon running ; Training ; Anthropometry ; Biochemistry ; Performance prediction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was aimed at investigating the relationships between marathon performance time (MPT) and a set of variables wider in scope than that used to date in similar studies. Sixteen marathon runners of varying abilities were examined for the following variables prior to the start of a marathon race: age, weight (wt); height (ht); triceps, abdominal and subscapular (SSF) skinfolds; % fat; rectal temperature; average weekly training distance over the preceding 2–3 months and over the preceding year (ATD); hematocrit; creatine phosphokinase (CPK); aldosterone and cortisol. MPT's ranged between 2; 15:21 and 4; 54:31 h. The coefficients of the simple linear correlations with MPT were: age, 0.70; wt·ht−2, 0.57; SSF, 0.67; % fat, 0.61; ATD, −0,64; CPK, 0.52 and cortisol, −0.41. In order of relative strength, CPK, age, ATD, SSF and cortisol were found by a multiple linear regression analysis to be the best predictors of MPT (R=0.99; p〈0.0001) — explaning 98% of its observed variance. The diversified approach may be supported by the high R value obtained. However, the significance of additional factors in determining MPT is expected and cannot be excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455191
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