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  • 1
    Electronic Resource
    Electronic Resource
    Lymphoid-associated neoplasia in herniated colonic mucosa (2002)
    Oxford UK : Blackwell Science Ltd
    Histopathology 40 (2002), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2002.t01-2-01294.x
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  • 2
    Electronic Resource
    Electronic Resource
    Big cones and little cones (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 2 (1978), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To investigate whether the amount of tissue removed at conization could influence the frequency of inadequate excision of cervical atypias, 354 cone specimens were measured. The data indicate that the frequency of lesions incompletely removed at conization increased with decreasing size (ie. length and volume) of the specimen. The parameters influencing the detection of epithelial atypias at the surgical margin of the specimens are discussed. A plea is made for international standardization in reporting results of conization (size of cone and number of sections) in order to permit objective comparison between clinics of the results of the conization procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1978.tb01701.x
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  • 3
    Electronic Resource
    Electronic Resource
    The immunofluorescence characteristics of the basement membrane in squamous carcinoma of the uterine cervix (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 2 (1978), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Basement membrane-specific antigens (BMSA) were found by immunofluorescence (IFL) in 20 of 33 tumour samples from patients with squamous carcinoma of the uterine cervix. The BMSA were demonstrated to be unrelated to condensation of both reticulin and subepithelial ground substance (as evidenced by antireticulin IFL antibodies, silver stain and PAS reaction, respectively), the age of the patient, the clinical stage and the histological differentiation of the tumour. The finding that BMSA secreting and non-secreting cervical tumours does not correlate with the degree of differentiation, was somewhat unexpected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1978.tb01694.x
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  • 4
    Electronic Resource
    Electronic Resource
    Adenocarcinoma in lymphoid-associated colonic mucosa (2000)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 37 (2000), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2000.00985.x
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  • 5
    Electronic Resource
    Electronic Resource
    The basement membrane in experimentally induced atypias and carcinoma of the uterine cervix in mice (1979)
    Springer
    Virchows Archiv 381 (1979), S. 205-209 
    Details
    ISSN: 1432-2307
    Keywords: Cervical carcinogenesis ; Basement membrane ; Immunofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Basement membrane-specific antigens of the squamous epithelium of the uterine cervix were investigated in 19 normal mice, in 7 mice with cervical atypia and in 3 mice with invasive carcinoma. Cervical atypia and carcinoma were induced by local application of benzo(a)pyrene. Basement membrane-specific antigens were demonstrated by immunofluorescence with sera from patients with bullous pemphigoid. Both normal squamous cervical epithelium and atypical cervical epithelium showed the presence of a continuous, clearly delineated basement membrane. Clusters of invasive squamous carcinoma were also surrounded by a fluorescent basement membrane which, however, appear fragmented or discontinuous. The results suggest that the ability of cervical squamous cells to secrete basement membrane antigens is not completely lost during carcinogenesis, thus substantiating our previous observations in the cervix of human subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257885
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  • 6
    Electronic Resource
    Electronic Resource
    Flat adenomas and flat adenocarcinomas of the colorectal mucosa in Japanese and Swedish patients (1995)
    Springer
    Diseases of the colon & rectum 38 (1995), S. 1075-1079 
    Details
    ISSN: 1530-0358
    Keywords: Colorectal mucosa ; Flat adenoma ; Carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: In recent years, flat adenomas of the colorectal mucosa have been intensively investigated by Japanese pathologists. Results of that work indicate that flat adenomas may antedate the development of colorectal carcinomas. Because of differences in the Histologic definition of flat adenomas with severe dysplasia and with intramucosal carcinoma within the group, one single observer having both Western and Asian training in pathology reviewed the material. METHODS: A total of 287 flat colorectal lesions were reviewed: 109 from the Karolinska Hospital, Stockholm, 137 from the Tokyo Medical and Dental University (TMDU) (which included 50 cases from the Nagoya City University), and 41 from the Cancer Institute (CI), Tokyo. Lesions were histologically classified following strict Histologic criteria. Thus, flat adenomas were divided into those having lowgrade dysplasia (LGD; having dysplastic cells in the deeper half of the epithelium), high-grade dysplasia (HGD; dysplastic cells were found even in the superficial half of the epithelium), intramucosal carcinoma (dysplastic glands displayed molding with buddings and often a cribriform pattern), and adenocarcinoma (breaking through the muscularis mucosa, with neoplastic cells in the submucosal layer or deeper). RESULTS: Whereas in Stockholm only 14.7 percent of lesions had HGD, as much as 56.9 percent and 56.1 percent, respectively, had HGD at the two Tokyo Hospitals. Intramucosal carcinomas were not found in the Stockholm material but occurred in 2.2 percent of lesions seen at TMDU and in 4.9 percent of those seen at the CI. Notably, only 2.7 percent of the specimens at Karolinska Hospital had invasive adenocarcinoma, but it was seen in as many as 4.4 percent at TMDU and 21.9 percent at the CI. CONCLUSIONS: This study indicates that there were Histologic differences between flat neoplasias of the colorectal mucosa harvested in Stockholm and Tokyo. In Japan, lesions were obviously more advanced (in terms of HGD) and more aggressive (in terms of intramucosal and submucosal invasion). The cause for the differences found in those two disparate geographic regions remains poorly understood. The results, however, may help us understand some of the unclear points and discussions appearing in the literature on this subject.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02133981
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  • 7
    Electronic Resource
    Electronic Resource
    Crohn's disease and adenocarcinoma of the intestinal tract (1991)
    Springer
    Diseases of the colon & rectum 34 (1991), S. 174-180 
    Details
    ISSN: 1530-0358
    Keywords: Crohn's disease ; Adenocarcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Four patients with intestinal adenocarcinoma complicating Crohn's disease are reported. The youngest of the four patients was a 21-year-old female with a 9-year history of Crohn's disease of the terminal ileum as well as of the entire colon. She developed mucus-producing moderately differentiated adenocarcinoma in the cecum. Of the remaining three patients with Crohn's disease, one presented an adenocarcinoma in the ascending colon, one in the rectum and the remaining one in the duodenum. All three colorectal adenocarcinomas originated in areas of high-grade dysplasia and all four in areas with chronic transmural inflammation. The review of the literature indicates that a total of 174 small and large bowel cancers occurring in Crohn's disease have been recorded (including the four reported herein). The vast majority of the reported cases have been found in the North American subcontinent. Only in a few instances were bowel adenocarcinoma and Crohn's disease observed in the European continent. It is therefore remarkable that three of our four cases were seen within a period of 12 months. Interestingly, six patients having colorectal adenocarcinoma in association with Crohn's disease were recently reported from a single hospital in England. The question therefore arises whether our cases and those reported recently from England are unrelated and merely coincidental or whether carcinomas are now also affecting European CD patients. If the latter is the case, the surveillance policy for patients with CD should be reconsidered at this hospital.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02049994
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  • 8
    Electronic Resource
    Electronic Resource
    Dose-time-dependent histological changes following irradiation of the small intestine of rats (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 392-401 
    Details
    ISSN: 1573-2568
    Keywords: irradiation ; histology ; small intestine ; rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distal ileum of 48 male Sprague-Dawley rats was exteriorized and irradiated either with low dosis (9–12 Gy,N=18 rats), moderate dosis (15–18 Gy,N=18 rats) or high dosis (21–24 Gy,N=12 rats). A shielded segment of the ileum in the same animals as well as the sham-irradiated exteriorized ileum of 10 rats served as controls. The animals were allowed to survive for 3, 10, or 30 days. A total of 16 histologic parameters were found to be relevant for this study. Cell necrosis, loss of goblet cells, crypt abscesses, structural changes of the crypts, loss of Paneth cells, decreased number of mitoses, appearance of clear basal cells, loss of margination of lymphocytes, increased colagen in the submucosa, muscularis propria and subserosa, ectopic mucosal glands, as well as mucosal ulcerations, were found to be dose-time-dependent irradiation changes. Racket-shaped superficial epithelial cells, capillary congestion, and an increased number of round cells in the lamina propria mucosa were found to be time-dependent histological parameters. Preparations from the shielded ileum or from the sham-irradiated control animals showed normal histology. This study appears to be the first in which the systematic analysis of several postirradiation histologic changes have been found to be dose- and/or time-dependent. The knowledge that some radiation changes are dose-time-dependent, whereas others are exclusively time-dependent, may open new vistas on the study of postradiation enteritis in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02093834
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  • 9
    Electronic Resource
    Electronic Resource
    “Nonspecific” erosions and ulcers of the colonic mucosa (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 821-826 
    Details
    ISSN: 1573-2568
    Keywords: erosions ; ulcerations ; colonic mucosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 26 cases of “nonspecific” erosions and ulcers of the colonic mucosa are reported. The most common causes were previous abdominal irradiation or ischemic disease due to arteriosclerosis. The lesions were localized to all segments of the colon. Of the 26 cases, five (19.2%) had erosions (ie, not penetrating beyond the muscularis mucosae) and the remaining 21, ulcers (ie, penetrating beyond the muscularis mucosae). In seven of the 26 cases (26.9%) more than one ulcer was found in the same specimen. Erosions may heal completely by epithelial regeneration (ie,restitutio ad integrum) while ulcers usually heal by replacing scarring tissue. Thus, the two lesions may not be clinically synonymous. The relatively high proportion of erosions among nonspecific ulcerations of the colonic mucosa has not been previously pointed out in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02087429
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  • 10
    Electronic Resource
    Electronic Resource
    Intraepithelial lymphocytes vs. colorectal neoplastic cells: Who is winning the apoptotic battle? (1997)
    Springer
    Apoptosis 2 (1997), S. 489-493 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; intraepithelial lymphocytes ; colorectal adenomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Intraepithelial lymphocytes (IELs) and Intraepithelial apoptotic granules (AGs) are found in the vast majority of colorectal adenomas, less frequently in incipient carcinomas and occasionally in advanced colorectal carcinomas. In colorectal adenomas, the activated and cytotoxic IELs undergo apoptosis by a Fas-FasL mechanism. In advanced invasive carcinomas lacking IELs, that mechanism cannot be activated. On the other hand, the peritumoural lymphocytes which surround some advanced invasive carcinomas may abrogate to-be-metastatic tumor cells, as treated cancer patients with peritumoural lymphocytes have a better 5-years' survival than those without that peritumoural barrier. In colorectal adenomas the host reaction (IELs) dysplastic cells Fas-dependent confrontation seems to prevent rapidly proliferating adenomas from becoming rapidly invasive carcinomas, since that process takes 10 to 20 years to evolve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026430313275
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