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  • 1
    Electronic Resource
    Electronic Resource
    Churg–Strauss syndrome in a case of asthma (2002)
    Oxford, UK : Munksgaard International Publishers
    Allergy 57 (2002), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2002.23618.x
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  • 2
    Electronic Resource
    Electronic Resource
    Design of Handover Procedures for Mobile Cellular Systems through Performance Charts (1997)
    Springer
    Wireless personal communications 5 (1997), S. 51-73 
    Details
    ISSN: 1572-834X
    Keywords: handover procedure ; design ; initiation phase ; execution phase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The paper proposes a design approach of handover procedures for mobile cellular systems. Performance charts, where the parameters of interest in the handover procedure design are linked to system requirements, are utilized to describe and apply the proposed design methodology. The design moves from a flexible system description. The paper describes the design technique together with the underlying system model. Design examples are provided and the design effectiveness is validated through an overall system simulator. The design approach is particularly advantageous as it joins flexibility to low complexity and satisfactory design accuracy. The results that have been achieved in the validation campaign confirm the effectiveness and usefulness of the approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008870821715
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  • 3
    Electronic Resource
    Electronic Resource
    A C/I advantageous satellite system configuration for land mobile applications (1997)
    Springer
    Telecommunication systems 8 (1997), S. 319-340 
    Details
    ISSN: 1572-9451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract A satellite system based on the frequency scanning concept has been recently assessed for L‐band land mobile communications. The study – promototed by ESA/ESTEC for an European application mission – has reached an advanced electrical design phase. The selected configuration is particularly advantageous in terms of Carrier‐to‐Intermodulation ratio (C/I) performance, which constitutes a requirement of key‐importance in the envisaged user applications. The advantage in C/I is due to the proper choice of the on‐board transmitter configuration, which adopts power module pairs where the overall power demand is evenly distributed. The consequent improved C/I is then achievable at both transmitter and radiated far field level. The present paper aims a contribution to the design methodology of frequency scanning satellite systems, by joining two key‐aspects: in fact an analytical approach is proposed to demonstrate the C/I advantage achievable through frequency scanning satellite systems and the methodology is applied to a concrete example, the ESA/ESTEC system, whose feasibility has been fully proved in previous studies. The analysis is performed both at transmitter level and in the far field. The main results achieved are hereinafter presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1019125924140
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  • 4
    Electronic Resource
    Electronic Resource
    Cathepsin D is a marker of ganglion cell differentiation in the developing and neoplastic human peripheral sympathetic nervous tissues (2000)
    Springer
    Virchows Archiv 437 (2000), S. 406-412 
    Details
    ISSN: 1432-2307
    Keywords: Keywords Cathepsin D ; Human fetus ; Sympathetic nervous system ; Neuroblastic tumours
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cathepsin D (CD) is an aspartic proteinase which has been immunolocalised in intestinal ganglion cells of human neonates and adults. The aim of the present study was to define whether CD is a reliable ganglion cell differentiation marker in routinely fixed, paraffin-embedded tissues. For this purpose, we investigated immunohistochemically the expression and distribution of CD in the developing human peripheral sympathetic nervous system (PSNS) and gastroenteric nervous system (GENS), and in childhood neuroblastic tumours (NTs; neuroblastomas, ganglioneuroblastomas and ganglioneuromas), where ganglion cells differentiate from immature neuroblastic cells. During ontogenesis, CD expression is restricted to ganglion cell lineage with a progressively more intense cytoplasmic staining, mirroring the morphological differentiation of ganglion cells with increasing gestational ages. In neoplastic tissues, CD immunoreactivity was restricted to neuroblastic cells showing morphological features of gangliocytic differentiation (differentiating neuroblastomas, ganglioneuroblastomas) as well as to neoplastic ganglion cells (ganglioneuroblastomas, ganglioneuromas). We conclude that CD is a reliable ganglion cell differentiation marker, which can be used routinely to stain developing and mature ganglion cells in formalin-fixed, paraffin-embedded tissues. Furthermore, our results indicate that CD immunoreactivity in childhood NTs recapitulates the changes during normal PSNS development, as previously reported for Bcl-2 oncoprotein, c-ErbB2, insulin-like growth factor 2 and β2-microglobulin. This is consistent with the current view that childhood NTs exhibit gene expression profiles mirroring those occurring during PSNS ontogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280000250
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  • 5
    Electronic Resource
    Electronic Resource
    The neurofibromatoses. An overview (1999)
    Springer
    Italian journal of neurological sciences 20 (1999), S. 89-108 
    Details
    ISSN: 1126-5442
    Keywords: Key words Neurofibromatosis ; Nf1 ; Nf2 ; Mosaic/segmental neurofibromatosis ; Variants ; Classification ; Neurological manifestations ; Genetics ; Childhood ; Adulthood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The last two decades have seen clinical and molecular delineation of the different forms of neurofibromatosis. Differentiation of these forms is not just an academic exercise: their natural history, management and genetic counselling are quite different. Of the numerical classifications of neurofibromatosis proposed in the past, only neurofibromatosis type 1 (Nf1) and neurofibromatosis type 2 (Nf2) are now well delineated clinically and have been shown to be distinct at the molecular level. For both forms of neurofibromatosis, patients with clinical generalised disease have been demonstrated to be mosaic at the molecular level, and features of segmental or mosaic Nf1 and Nf2 have been delineated. Other reported forms of neurofibromatosis are rarer; they include Watson syndrome, hereditary spinal neurofibromatosis, familial intestinal neurofibromatosis, autosomal dominant café-au-lait spots alone, autosomal dominant neurofibromas alone, and schwannomatosis, the latter believed to be a variant of Nf2. Further delineation is neeeded for individuals having overlapping features of Noonan's syndrome and neurofibromatosis (the so-called Noonan/neurofibromatosis syndrome) and the syndrome of “multiple naevi, multiple schwannomas and multiple vaginal leiomyomas”. In this article we review the forms of neurofibromatosis which we believe are true clinical entities. Particular attention is given to the neurological manifestations of neurofibromatosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720050017
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  • 6
    Electronic Resource
    Electronic Resource
    Primary osteoma cutis — multiple café-au-lait spots and woolly hair anomaly (1995)
    Springer
    Pediatric radiology 25 (1995), S. 34-36 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An 11-year-old girl with typical features of primary osteoma cutis is reported. She demonstrated multiple areas of subcutaneous, asymptomatic, slow-growing nodules, mostly localized at the extremities. Radiographic evidence of soft tissue calcification and histologic confirmation of ectopic bone formation was obtained. She also showed café-au-lait spots, woolly hair and intrauterine growth deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02020840
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  • 7
    Electronic Resource
    Electronic Resource
    The effects of heparin on the adherence of five species of urinary tract pathogens to urinary bladder mucosa (1984)
    Springer
    Urological research 12 (1984), S. 199-203 
    Details
    ISSN: 1434-0879
    Keywords: Heparin ; Bladder mucosa ; Bacterial adherence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous studies performed in our laboratory have indicated that the primary antibacterial defense mechanism of the rabbit urinary bladder is the antiadsorptive action of the surface mucopolysaccharide. Removal of this layer with an acid rinse increases bacterial adherence up to 100 fold. Exogenous mucopolysaccharide (heparin) has been shown to restore Escherichia coli adherence to control levels. To determine whether this antiadherence action of heparin is species specific, we compared the adherence of 5 common urinary tract pathogens (Escherichia coli, Klebsiella ozonae, Proteus mirabilis, Pseudomonas aeruginosa, and Streptococcus fecalis) to both mucin intact and mucin deficient rabbit bladders with and without prior heparin exposure. Bacteria were radiolabeled by addition of 3H-adenine to the culture broth so that the number of bacteria adhering to the bladder could be determined using liquid scintillation spectrophometry. Results were as follows: 1) Acid removal of the mucin layer significantly increased the adherence approximately 10 fold for all 5 species tested. 2) Briefly exposing the mucin deficient bladders to heparin decreased the adherence of all species tested except Pseudomonas to mucin intact control levels. 3) Heparin treatment of mucin intact bladders slightly decreased adherence of all species except Pseudomonas below mucin intact controls, however, results were not statistically significant. 4) The magnitude of Klebsiella adherence was nearly 20 fold greater than all other species tested. While this non-species specific adherence inhibition of heparin may prove useful in the clinical setting, it appears to be less effective against Pseudomonas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256803
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  • 8
    Electronic Resource
    Electronic Resource
    Mannose inhibition of Escherichia coli adherence to urinary bladder epithelium: Comparison with yeast agglutination (1985)
    Springer
    Urological research 13 (1985), S. 79-84 
    Details
    ISSN: 1434-0879
    Keywords: E. coli adherence ; Mannose binding ; Yeast agglutination ; Urinary bladder ; Urinary tract infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The adherence of piliated strains of Escherichia coli (E. coli) to mammalian epithelial cells has been reported by several investigators to be specifically inhibited by D(+)-mannose or its derivatives. Much of this work utilized mannose type compounds to inhibit agglutination of mannan containing yeast cells by E. coli to demonstrate mannose sensitivity. This report investigates the ability of the neotype strain of E. coli (which is sensitive to mannose inhibition of yeast cell agglutination) to bind and metabolize radiolabeled D(+)-mannose. In addition the relative efficacy of D(+)-mannose and heparin to inhibit the adherence of E. coli to rabbit bladder mucosa was compared. Results showed that although D(+)-mannose did block E. coli-yeast cell agglutination in a reversible manner, radiolabeled D(+)-mannose binding by E. coli could not be displaced by 1,000 fold excess unlabeled D(+)-mannose. This suggests uptake of the sugar as opposed to a surface binding phenomenon which was confirmed by the demonstration of significant metabolism of mannose by E. coli. The same concentration of D(+)-mannose which prevented E. coli-yeast cell agglutination was not particularly effective in preventing E. coli adherence to the acid denuded rabbit bladder. Heparin treatment of the acid denuded bladder was very effective in preventing E. coli adherence but was ineffective in preventing E. coli-yeast cell agglutination. This indicates that E. coli-yeast cell agglutination should not be correlated with E. coli adherence to mammalian epithelial tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261571
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  • 9
    Electronic Resource
    Electronic Resource
    Current status of interstitial cystitis (1990)
    Springer
    World journal of urology 8 (1990), S. 212-217 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Until recently, interstitial cystitis (IC) was considered a urologic curiosity, a rare problem that most urologists would see only a few times during a career. It was easy to diagnose, with strict and rigid criteria having been set early in this century [28]. This situation has changed drastically in the last 15 years, largely as a result of patients themselves, who have banded together in large, well-organized lobbying and self-help groups throughout North America. The medical catalyst for the change came from a paper published in 1978 by Messing and Stamey [39], who proposed that previous diagnostic criteria for the disease were too limited. IC is now a very controversial subject that has ignited the interest of physicians in many nations and has sparked a major basic scientific research effort to discern its etiology and discover potential treatment modalities. The major effort in the last 5 years has been devoted to the attempt to define the disorder. In this article we review the current status of interstitial cystitis with regard to issues of definition, epidemiology, diagnosis, and treatment. Finally, current avenues of research are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01580023
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  • 10
    Electronic Resource
    Electronic Resource
    Gross deletions of the neurofibromatosis type 1 (NF1) gene are predominantly of maternal origin and commonly associated with a learning disability, dysmorphic features and developmental delay (1998)
    Springer
    Human genetics 〈Berlin〉 102 (1998), S. 591-597 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mutation screening in neurofibromatosis type 1 (NF1) families has long been hampered by the complexity of the NF1 gene. By using a novel multi-track screening strategy, 67 NF1 families (54 two-generation, 13 three-generation) with a de novo mutation in the germline of the first generation were studied with two extragenic and 11 intragenic markers. The pathological lesion was identified in 31 cases. Loss of heterozygosity (LOH) in the affected individual revealed a gross gene deletion in 15 of the two-generation families; in 12 (80%) of them, the deletion was maternally derived. Eleven patients with a gross deletion exhibited developmental delay, ten had dysmorphic features and six manifested a learning disability. No gross deletion was apparent in any of the 13 three-generation families, suggesting that such lesions are subject to more intense selection. In these families, the new mutation was of paternal origin in 11 kindreds and the underlying mutational event could be characterised in three of them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050746
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