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  • 1
    Electronic Resource
    Electronic Resource
    bcl-2 and p53 immunophenotypes in pre-invasive, early and advanced oesophageal squamous cancer (1997)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 31 (1997), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An inverse correlation between bcl-2 and p53 expression has been reported in several types of epithelial tumour. The role of bcl-2 and p53 in the development of oesophageal squamous carcinoma has yet to be established. The expression of bcl-2 and p53 proteins has been evaluated in the multistage oesophageal tumorigenesis, which progresses from normal mucosa to dysplasia (squamous intraepithelial lesion, SIL), to invasive early and advanced oesophageal squamous cancer.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and results:Sixty-four cases of squamous oesophageal cancer, coexisting with SIL in 18 cases, were immunohistochemically analysed for any overexpression of bcl-2 and p53 proteins. Any association of bcl-2 and p53 protein expression with patient survival was also analysed. We observed bcl-2 expression that decreased significantly during the progression of oesophageal carcinogenesis. A decreasing frequency in the expression of bcl-2 in advanced oesophageal squamous cancer coincided with frequent p53 overexpression. bcl-2 expression was correlated with patient survival by univariate analysis. The association disappeared after adjusting for tumour stage. p53 overexpression showed no association with patient survival by either univariate or multivariate analysis.〈section xml:id="abs1-3"〉〈title type="main"〉Conclusions:The down-regulation of bcl-2 and up-regulation of p53 in advanced oesophageal squamous cancer suggest that bcl-2 and p53 proteins may interact in the progression of oesophageal squamous cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1997.2970888.x
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  • 2
    Electronic Resource
    Electronic Resource
    Renal effects of nadolol in cirrhosis (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 473-477 
    Details
    ISSN: 1432-1041
    Keywords: nadolol ; cirrhosis ; beta-blockers ; renal failure/-function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of nadolol on renal haemodynamics and function, and on the renin-angiotensinaldosterone system and on renal prostaglandin production were studied in eighteen cirrhotics. After 1 month of treatment, nadolol had significantly decreased cardiac output by 25% without affecting arterial pressure, renal plasma flow or renal vascular resistance. Glomerular filtration rate, filtration fraction and the proportion of the cardiac output delivered to the kidneys were significantly increased. The renin-angiotensin-aldosterone system was suppressed and urinary PGE2 excretion was slightly increased. The latter effects were not correlated with those on renal haemodynamics and function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544238
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  • 3
    Electronic Resource
    Electronic Resource
    Long-term effect of nadolol on quantitative liver function tests in patients with cirrhosis (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 501-504 
    Details
    ISSN: 1432-1041
    Keywords: liver cirrhosis ; nadolol ; portal hypertension ; liver circulation/-function ; aminopyrine ; galactose elimination ; indocyanine green clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Nadolol, a non-cardioselective beta adrenoreceptor blocking agent, has been reported to decrease portal pressure without affecting liver function in cirrhotic patients treated for 1 month. There were no data about the long-term effects of nadolol on liver function. In 11 patients with cirrhosis and portal hypertension galactose eliminating capacity, aminopyrine metabolic capacity, ICG clearance and IGC intrinsic hepatic clearance according to the “parallel tube” model were measured before and after 6 months of treatment with nadolol at a dose reducing resting heart rate by approximately 25%. No significant variation in any of these parameters was found. Thus 6 months of continuous oral administration of nadolol did not further impair liver function in cirrhotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01046709
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  • 4
    Electronic Resource
    Electronic Resource
    Anastomotic stenoses occurring after circular stapling in esophageal cancer surgery (2000)
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 670 -674 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Anastomic stenosis — Endoscopic dilatation — Esophagogastrostomy — Stapled anastomosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Circular staplers have reduced the incidence of anastomotic leaks in esophagovisceral anastomosis. However, the prevalence of stenosis is greater with staplers than with manual suturing. The aim of this study was to analyze potential risk factors for the onset of anastomotic stenoses and to evaluate their treatment and final outcome. Methods: Between 1990 and 1995, 187 patients underwent esophagectomy and esophagogastrostomy with anastomosis performed inside the chest using a circular stapler. Results: Twenty-three patients (12.3%) developed an anastomotic stenosis. The incidence of strictures was inversely related to the diameter of the stapler. Concomitant cardiovascular diseases; morphofunctional disorders of the tubulized stomach, such as those related to duodenogastric reflux; and neoadjuvant chemotherapy were also recognized as significant risk factors. Endoscopic dilatations proved safe and were effective in the treatment of most anastomotic stenoses. Conclusions: To reduce the risk of anastomotic stenosis after stapled intrathoracic esophagogastrostomy, adequate vascularization of the viscera being anastomized should be maintained, and it is mandatory to use the largest circular stapler suitable. Furthermore, it is essential to reduce the negative inflammation-inducing effects of duodenogastroesophageal reflux to a minimum. Endoscopic dilatations are safe and effective in curing the great majority of anastomotic stenoses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004640000020
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  • 5
    Electronic Resource
    Electronic Resource
    Postsinusoidal portal hypertension in a patient with chronic lymphatic leukemia (1963)
    Springer
    Digestive diseases and sciences 8 (1963), S. 845-851 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of chronic lymphatic leukemia with ascites is reported in which the hepatic vein catheterization revealed portal hypertension with patterns of intrahepatic obstacle. Splenoportography demonstrated the patency of the splenoportal trunk; hepatography did not present the typical cirrhotic pattern. On the basis of pathological findings the portal hypertensive syndrome was found to be supported only by the massive leukemic infiltration of the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02232076
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    Paper (German National Licenses)
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