ISSN:
1749-6632
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Natural Sciences in General
Notes:
Amyloid β-protein, or β/A4, is a 4-kilodalton peptide that forms poorly soluble extracellular depositions of amyloid in brains and leptomeninges of patients with Alzheimer's disease (AD), Down's syndrome (DS), and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). β/A4 peptide is a derivative of a large transmembrane glycoprotein (APP) and is found in the extracellular space, i.e., in the cerebrospinal fluid and serum of individuals with and without AD and in the conditioned media of many different cells grown in culture.1 The mechanism by which normally produced amyloid β peptide forms extracellular aggregates in patients is unknown. One possible explanation is a failure of a mechanism for removal of the β/A4 peptide that prevents this highly aggregating peptide from forming extracellular amyloid depositions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1749-6632.1993.tb23042.x
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