ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
Although natural killer (NK) activity is not restricted by the major histocompati-bility complex (MHC), it has been suggested that the level of expression of MHC antigens by target cells may influence their lysis by NK cells. We have studied the NK susceptibility of 20 cell lines obtained from primitive and metastatic human tumours and the K562 cell line treated with γ-interferon, phorbol ester TPA and tumour factor NK-RIF.When the levels of MHC class I antigen expression on the human tumour cell lines and their NK susceptibility were compared, no relationship between these two parameters was observed. Futhermore the treatment of K562 with either γ-interferon, TPA or NK-RIF decreased its NK susceptibility independently of MHC class I expression.These results indicate that the MHC class I antigen is not the only factor directly involved in NK susceptibility and suggest that other membrane structures modulated by γ-interferon, TPA or NK-RIF may also influence NK susceptibility.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1989.tb00488.x
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