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  • 1
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Seven asthmatic and five normal subjects inhaled increasing amounts of nebulized water (“fog”). Neutrophil chemotactic activity (NCA), histamine and FEV1 measurements were undertaken before and at time intervals after challenge. In asthmatics, the mean maximal reduction in FEV1 (± 1 SD) was 46.6%± 11.5; whereas, in normal subjects, the reductions were less than 20% of pre-challenge values after the inhalation of 33 ml of water. There were no significant differences in the pre-challenge values for NCA between the asthmatics and the normal controls. When the highest values for NCA during the 30 min after challenge in the asthmatics were compared with controls there was a significant increase (P 〈 0.02). The percentage change in NCA was also significantly greater in the asthmatics compared with the controls at 10 min after challenge (P 〈 0.05). Fog-induced NCA was shown to be associated with proteins with approximate molecular weight of 600,000 daltons (as assessed by gel filtration chromatography on Sephacryl-S400). There was an increase in plasma histamine in the asthmatics after challenge but this was not significantly greater than the controls. These findings support the view that mediators might be involved in fog-induced asthma, possibly as a result of mast cell degranulation by “osmotic shock”.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 18 (1988), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In an attempt to understand the relationship between viral upper respiratory tract infection and the underlying virological and immunological mechanisms, thirty-four volunteers were inoculated intranasally with coronavirus 229E; subsequent virus shedding and/or antibody rises, indicating active infection, were observed in twenty-nine. There was a greater increase in independently measured scores of clinical severity, e.g. cold symptoms, in those with detectable IgE in nasal secretions (P 〈 0.01). A similar association was found between clinical scores and serum IgE concentrations 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:09547894:CEA119:ges" location="ges.gif"/〉 150 IU/ml, but the relationship with systemic atopy, as assessed by skin-prick tests to common allergens, was less marked. A more detailed study of twelve of the infected volunteers failed to explain these findings on the basis of mast ceil mediator release, as concentrations of leukotriene B4, the sulphidopeptide leukotriene C4, and histamine, were not appreciably elevated in the nasal secretions following virus inoculation. Similarly, there was no evidence that circulating coronavirus specific IgE was produced. Thus, this study suggests that atopy may be related to the severity of cold symptoms produced by coronavirus 229E, although the exact connection has yet to be determined.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Leukotrienes are a recently discovered group of arachidonic acid-derived lipid mediators. Using radioimmunoassay and high pressure liquid chromatography (HPLC), we have identified the SRS-A sulphidopeptide leukotrienes (LTC4, LTD4 and LTE4) in nasal washings from patients with allergic rhinitis who underwent nasal challenge with specific allergen. Smaller, but significant, amounts of LTB4 were also detected. The concentrations of nasal leukotrienes were directly related to the dose of allergen, and were recovered in washings in a time-dependent fashion after challenge. When the patients were subjected to methacholine nasal challenge on a control day, we found only negligible amounts of either the sulphidopeptide leukotrienes or LTB4. These findings support the view that LTC4, LTD4 and LTE4 might contribute to the pathogenesis of allergic rhinitis as a result of their recognized effects on mucous hypersecretion and vasopermeability, and that the potent chemoattractant LTB4 might be involved in the subsequent infiltration of inflammatory cells.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We found that normal eosinophils generated appreciable amounts of SRS-A leukotrienes when incubated with IgG-coated particles, and that this was enhanced twofold when cells were stimulated in vitro (by the bacterial analogue f-Met-Leu-Phe (fMLP)) and up to 10-fold when activated low-density cells ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Irrigation science 6 (1985), S. 73-83 
    ISSN: 1432-1319
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Fine textured soils (〉 40% clay) form a major proportion of irrigated soils in northeastern Australia. More than half these soils are irrigated with groundwater, some of which has high salinity (electrical conductivity 〉 2.9 mS cm−1). A simple prediction of salt leaching was sought to aid in land management decisions. An empirical model of leaching fraction is presented based on rainfall and easily measured soil properties related to hydraulic conductivity. The model is based on data from 766 soils. To account for the complexity of interactions between soil properties, the data was stratified into groups based on clay content and mineralogy (expressed here as CEC/clay ratio). This allowed simple linear regressions using ESP and rainfall to be developed to predict leaching fraction. When applied to irrigated soils, a salinity correction term (ECrain+irrigation/ECrain) was used to account for the flocculation effects of the increased salinity of irrigation waters. The model gave good predictions of leaching fraction for two irrigation regions with widely differing soil properties (Fig. 4).
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Irrigation science 11 (1990), S. 199-207 
    ISSN: 1432-1319
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The steady-state leaching requirement (LR) model (USSL 1954) and the transient solute mass balance model of Rose et al. (1979) were applied to soil chloride data from 42 sites in Queensland, Australia, to evaluate utility of the models for assessing the impact of irrigation on soil salinity and leaching. Data were taken from previous studies on salinity in irrigated soils, and covered a wide range of soil types and irrigation managements. The time taken for soil chloride levels to reach steady-state was assessed from the transient model, and was calculated to be years (〉 3) or decades. These calculations showed that 19 sites had been sampled prior to steady-state, so that a strict application of the LR model was invalid. However, at only seven of these sites were there significant differences between sampled soil chloride and the calculated final values. At these seven sites leaching fluxes calculated with the two models differed by 3–162 mm y−1. At two sites leaching fluxes were ≤0 and the LR model could not be used to interpret soil chloride dynamics. Although both models assume constant inputs through time, variations in irrigation management practices at most sites had little practical effect on model predictions. However, where there were extreme variations in irrigation application or irrigation water chloride concentration, calculated leaching fluxes and thus predicted chloride levels were markedly affected. These models should not be applied in this situation. The transient model was preferred to the steady-state LR model for assessing the effect of irrigation on soil salinity, because of its ability to provide predictions of future soil chloride levels under non-steady conditions, and where leaching flux values are ≤ 0.
    Type of Medium: Electronic Resource
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