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  • 1
    Electronic Resource
    Electronic Resource
    Observations on the regulation of chemical intake in chronic carcinogenesis studies
    Amsterdam : Elsevier
    Food and Cosmetics Toxicology 8 (1970), S. 297-299 
    Details
    ISSN: 0015-6264
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0015-6264(70)80005-0
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  • 2
    Electronic Resource
    Electronic Resource
    Carcinogenic activity of hexacholorobenzene in hamsters (1977)
    [s.l.] : Nature Publishing Group
    Nature 269 (1977), S. 510-511 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Six-week-old Syrian golden hamsters from the Eppley colony were used. They were fed ad libitum for life a diet containing 50, 100 and 200 parts per million (p.p.m.) HCB. The HCB was more than 99.5% pure (BDH, England). Dosage regime and experimental design are shown in Table 1. At 50 weeks of age, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/269510a0
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  • 3
    Electronic Resource
    Electronic Resource
    An electronmicroscopic study of skin carcinogenesis in the mouse with special reference to the intramitochondrial body
    Amsterdam : Elsevier
    Experimental Cell Research 27 (1962), S. 608-611 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(62)90032-0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ascorbic acid and nitrosamines (1974)
    [s.l.] : Nature Publishing Group
    Nature 252 (1974), S. 179-179 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] EDGAR1 has proposed that ascorbic acid might inhibit the carcinogenic action of nitrosamines and other carcinogens that may act by alkylation. The rationale was that ascorbate might be alkylated in vivo before the carcinogens can react with cell macromolecules. The experimental basis for Edgar's ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/252179a0
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  • 5
    Electronic Resource
    Electronic Resource
    Synergistic effect of ferric oxide on dimethylnitrosamine carcinogenesis in the Syrian golden hamster (1973)
    Springer
    Journal of cancer research and clinical oncology 79 (1973), S. 31-38 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die carcinogene Wirkung von subkutan injiziertem Dimethyl-Nitrosamin (DMN) beim syrischen Goldhamster sowie der synergistische Effekt von intratrachealer Instillation von Eisenoxyd wurde untersucht. DMN allein verursachte cavernöse Haemangiome, Haemangioendotheliome, Haemangioendotheliosarkome sowie ein Hepatom in der Leber und ein Papillom des Magens, aber keine Tumoren des Atmungstraktes. Wenn Eisenoxyd zusätzlich zu DMN gegeben wurde, konnten Lebertumoren vaskulären und biliären Ursprungs gefunden werden, aber auch noch Tumoren der Nasenhöhle, neuroepitheliale Tumoren und ein Adenom. Daraus wird geschlossen, daß subkutan injiziertes DMN ein sehr wirksames Carcinogen für den syrischen Goldhamster darstellt, das Lebertumoren vaskulären, biliären und hepatozellulären Baues erzeugt. Das Fehlen der cancerogenen Wirkung im Atmungstrakt wird auf das Fehlen eines Metabolismus des DMN in der Lunge zurückgeführt.
    Notes: Summary The carcinogenic effect of dimethylnitrosamine (DMN) injected subcutaneously in Syrian golden hamsters as well as the synergistic effect of intratracheal instillations of ferric oxide were studied. DMN alone induced cavernous hemangiomas, hemangioendotheliomas, hemangioendotheliosarcomas, as well as one hepatoma of the liver and one papilloma of the forestomach, but no tumors of the respiratory system. When ferric oxide was given in addition to DMN, liver tumors of vascular and biliary origin were seen, in addition to tumors of the nasal cavity, neuroepithelial tumors and one adenoma. It was concluded that subcutaneously injected DMN is a powerful hepatic carcinogen for the Syrian golden hamster, producing liver tumors of vascular, bile duct as well as liver cell origin. The lack of tumorigenic effect in the respiratory system was considered to be due to the lack of metabolism of DMN in the lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284337
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  • 6
    Electronic Resource
    Electronic Resource
    Carcinogen — Induced skin tumorigenesis in mice: Enhancement and inhibition by ultraviolet light (1973)
    Springer
    Journal of cancer research and clinical oncology 79 (1973), S. 234-240 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Untersucht wurde die Einwirkung sowohl einmaliger wie wiederholter Anwendung von UV auf die Entstehung von durch DMBA hervorgerufenen Tumoren. Eine einzelne subcancerogene Dosis von UV vor der wiederholten Behandlung mit dem Cancerogen verdoppelte die Zahl der gut- und bösartigen Tumoren, was auf eine fördernde Wirkung hinweist. Die morphologischen Charakteristika der Tumoren (Plattenepithelpapillome, Keratoakanthome, Plattenepithel-Carcinoma) wurden durch UV nicht wesentlich verändert; nur eine etwas stärkere Stromafibrose und Gefäßhyalinisierung konnte beobachtet werden. Wiederholte Anwendung von UV allein rief Tumoren epidermalen und dermalen Ursprungs hervor: Acanthopapillome, Fibropapillome, Plattenepithelcarcinome und einige Fibrosarcome. Wenn sowohl UV wie DMBA wiederholt angewendet wurden (UV nach DMBA), war die Reaktion der Tumoren ähnlich der nach Anwendung von UV allein; die Zahl der Tumoren war jedoch etwas geringer und die Latenzzeit etwas größer als wenn DMBA allein angewendet wurde, was auf eine Hemmwirkung von UV hindeutet.
    Notes: Summary The effect of a single application of UV light as well as repeated applications of UV light on skin tumorigenesis in mice induced by 7,12-dimethylbenz(a)anthracene was studied. A single subcarcinogenic application of UV light before repeated carcinogen treatment almost doubled the number of benign and malignant tumors, pointing to an enhancing effect of UV light. The morphological characteristics of tumors (squamous papillomas, keratoacanthomas and squamous cell carcinomas) induced by repeated chemical carcinogen applications were not significantly altered by a preceding application of UV light; only a slightly stronger stromal fibrosis and vascular hyalinization ensued. Repeated UV light applications alone produced tumors of both epidermal and dermal origin: acanthopapillomas, fibropapillomas, squamous cell carcinomas and fibrosarcomas. When both UV light and DMBA were given repeatedly (UV light was given after DMBA) the tumor response was morphologically similar to that produced by UV light alone; however, the number of tumors was slightly less and the latent period was longer than when DMBA was given alone, which points to an inhibitory effect of UV light.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304015
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