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  • 1
    Electronic Resource
    Electronic Resource
    Genetic Basis of the Thalassæmia Diseases (1959)
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 1903-1909 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN recent years it has become clear that the abnormal human haemoglobins, such as haemoglobins S, C, D, E, etc., are variants of the normal protein (haemoglobin A), differing from it by the substitution of perhaps not more than a single amino-acid residue by a new one1. These mutant forms are ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1841903a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Human Hæmoglobin A 2 : Chemistry, Genetics and Evolution (1961)
    [s.l.] : Nature Publishing Group
    Nature 190 (1961), S. 1079-1084 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE normal individual has at least three types of haemoglobin. In foetal life and in early infancy he has a specific foetal haemoglobin (F). Within a few months of birth this haemoglobin has been replaced by adult haemoglobin (A), together with a small proportion of another haemoglobin (-4'8)-1. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1901079a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Co-Linearity of the Gene with the Polypeptide Chain (1964)
    [s.l.] : Nature Publishing Group
    Nature 201 (1964), S. 13-17 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE 'sequence hypothesis' states that the amino-acid sequence of a protein is specified by the nucleotide sequence of the gene determining that protein1. It has always been assumed that a simple congruence exists between these two sequences such that the order of the codons in the gene is the same ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/201013a0
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  • 4
    Electronic Resource
    Electronic Resource
    Haemoglobin A′ 2 : α 2 δ 2 16 Glycine→Arginine (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 1217-1218 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] HAEMOGLOBIN A2 has been shown to have the same a-chains as haemoglobin A, but to differ from it in the non-a-chains, which are named β in A and δ in A2 (refs. 1-5). Two variants of haemoglobin A2 (a2δ2) have been described where the difference in chemical structuie rests in the δ- rather than in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2091217a0
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  • 5
    Electronic Resource
    Electronic Resource
    Behavioral and cellular effects of serotonin on locomotion and male mating posture in Ascaris suum (Nematoda) (1996)
    Springer
    Journal of comparative physiology 178 (1996), S. 655-667 
    Details
    ISSN: 1432-1351
    Keywords: Acetylcholine ; Motor nervous system ; Serotonin ; Biogenic amines ; Male mating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The site and mode of action of serotonin on locomotion were investigated in the parasitic nematode Ascaris suum. Injection of serotonin into Ascaris immediately caused paralysis in animals that were generating locomotory waveforms. Injected serotonin also increased body length and decreased the number of propagating body waves. Similar injections into the male tail produced a ventral tail curl. Injection of N-acetyl-serotonin had no effect on the generation of locomotory waveforms, but increased the body length and decreased the number of body waves in the waveform. Other biogenic amines were also tested but were much less potent. Serotonin decreased the amplitude of a submaximal acetylcholine-induced muscle contraction and increased the time to attain this contraction. The time course of this effect on the response to ACh was much slower than the action of injected serotonin on locomotory waveforms, suggesting that additional elements are involved in the action of serotonin on locomotory behavior. Serotonin abolished spontaneous slow potentials in VI motor neurons and decreased the frequency of EPSPs in DE2 motor neurons, probably by a pre-synaptic mechanism. In the male tail, serotonin depolarized the male-specific transverse ventral muscle cells, but did not affect either dorsal or ventral longitudinal muscle cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227378
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  • 6
    Electronic Resource
    Electronic Resource
    Genetic Code: The ‘Nonsense’ Triplets for Chain Termination and their Suppression (1965)
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 994-998 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE nucleotide sequence of messenger RNA is a code determining the amino-acid sequences of proteins. Although the biochemical apparatus which translates the code is elaborate, it is likely that the code itself is simple and consists of non-overlapping nueleotide triplets. In general, each ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/206994a0
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  • 7
    Electronic Resource
    Electronic Resource
    The amber mutation (1964)
    Philadelphia : Wiley-Blackwell
    Journal of Cellular and Comparative Physiology 64 (1964), S. 43-49 
    Details
    ISSN: 0095-9898
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1030640406
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    Paper (German National Licenses)
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