ISSN:
0894-3230
Schlagwort(e):
Organic Chemistry
;
Physical Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
,
Physik
Notizen:
First-order rate constants for the acid-catalysed cleavage of adenine base from 2′-deoxyadenosine, its 3′ - and 5′- monophosphates, various dinucleoside monophosphates, trinucleoside diphosphates and hexameric 2′-deoxyadenylic acid were measured by the method of initial velocity. The results obtained were compared with the effect that hetroassociation with caffeine has on the pre-equilibrium protonation and rate-limiting heterolysis of 2′ -deoxyadenosine and its isosteric analogue, 1-(2-deoxy-β-D-erythro-pentofuranosyl) benzimidazole. The kinetics of the depurination of poly (dA-T), poly(dA) and a mixture of poly(dA) and poly(T) were determined, and the rate variations observed are discussed on the basis of the known structures of these polymers.
Zusätzliches Material:
2 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/poc.610051208
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