ISSN:
1365-2044
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Reversal of vecuronium-induced neuromuscular blockade with neostigmine was compared in two groups of 16 subjects: patients with Type 2 diabetes mellitus and normal controls. When the first twitch of the train-of-four had returned to 25% of the control value, neostigmine 40 μg.kg−1 and atropine 20 μg.kg−1 were given to reverse the neuromuscular blockade. The train-of-four ratio was lower at 3 min, 6 min, 9 min, 12 min and 15 min after reversal in the diabetic group than in the control group but the differences did not reach statistical significance. Fifteen minutes after reversal, the number of patients in whom recovery from neuromuscular blockade was judged insufficient to guarantee good respiratory function (train-of-four ratio 〈 0.74) did not differ between the groups. However, 15 min after reversal, the number of patients with a train-of-four ratio 〈 0.9 was significantly higher in the Diabetic Group than in the Control Group (15 vs. 10, p = 0.033).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2044.2004.03833.x
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