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  • 1
    Electronic Resource
    Electronic Resource
    Glycogenosis of the central nervous system in the cat (1969)
    Springer
    Acta neuropathologica 14 (1969), S. 194-200 
    Details
    ISSN: 1432-0533
    Keywords: Electronmicroscopy ; Glycogenosis ; Central Nervous System
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein Fall von Glykogenose bei der Katze wird beschrieben. Die Krankheit hat das Zentralnervensystem befallen und zeigt das gleiche ultrastrukturelle Aussehen wie die Pompesche Krankheit. Glycogenosis bei einem Tier ist bisher nicht beschrieben worden. Als Erleichterung zukünftiger Forschungen dürfte es nunmehr möglich sein, einen Katzenstamm mit dieser Krankheit zu züchten.
    Notes: Summary A case of glycogenosis in the cat involving the central nervous system is reported. The electron microscopic picture is highly suggestive of Pompe's disease. Glycogen storage disease in an animal has not been reported before. From the present study it appears to be possible to achieve a strain of cats with this disease, which would greatly facilitate further research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685299
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of hydralazine on steady-state plasma concentrations of metoprolol in pregnant hypertensive women (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 131-135 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; hydralazine ; hypertension ; pregnancy ; pharmacokinetics ; drug interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the plasma concentrations levels of metoprolol after its twice daily administration in a dose of 50 mg for 4 days in ten, hypertensive pregnant women to the during monotherapy and in combination with 25 mg of hydralazine given twice daily. Hydralazine increased the median AUC and Cmax of metoprolol by 38% and 88% respectively, and decreased the tmax from 1.5 h to 1.0 h. Hydralazine had no effect on the plasma concentrations of alpha-OH-metoprolol. These results suggest that the effect of hydralazine on metoprolol plasma concentrations is primarily due to a reduction in first-pass elimination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609241
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Disposition of the adrenergic blocker metoprolol and its metabolite OH-metoprolol in maternal plasma, amniotic fluid and capillary blood of the neonate (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 363-368 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; neonates ; amniotic fluid ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Seven women were treated with metoprolol 50–100 mg twice daily for hypertension in pregnancy. The disposition of metoprolol and one of its metabolites alfa-OH-metoprolol was studied in venous plasma and amniotic fluid during labour, in mixed cord plasma and in capillary blood of the newborn. Peak concentrations of metoprolol and alfa-OH-metoprolol were reached 60 to 120 min after dosing in maternal plasma while the amniotic fluid levels of these compounds continued to increase from 60 to 180 min to the end of the study and were substantially higher than in the plasma after 4 to 5 h. It is postulated that a major fraction of metoprolol and alfa-OH-metoprolol reaches the amniotic fluid via the fetal urine and that the elimination from the amniotic fluid mainly proceeds via diffusion across fetal membranes and transfer across the fetal capillary bed. No measurable concentrations of metoprolol were found in two of the newborns 2 h after delivery. In the remaining four neonates the 2-h concentrations exceeded the corresponding cord plasma levels. In all neonates the alfa-OH-metoprolol levels in the capillary blood were higher 2 h after birth than in cord blood. In two newborns the metabolite levels continued to increase for 5 h and in one the highest blood concentrations of this metabolite was found 20 h after birth. Redistribution of metoprolol from tissue stores followed by metabolism might be the cause of these temporary elevations of the blood levels of metoprolol and alfa-OH-metoprolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637631
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  • 4
    Electronic Resource
    Electronic Resource
    Manganese Status during Pregnancy (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 678 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb26146.x
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  • 5
    Electronic Resource
    Electronic Resource
    Serum Concentrations of Trace Elements in Infants and Their Mothers during Pregnancy (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 678 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb26145.x
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  • 6
    Electronic Resource
    Electronic Resource
    Non-freezing light- and electron microscopic enzyme histochemistry by means of polyetylene glycol embedding (1969)
    Springer
    Histochemistry and cell biology 19 (1969), S. 181-183 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A technique is described, by means of which the undesirable effects by freezing and thawing necessary in cryostat histochemistry might be avoided using embedding in polyetylene glycol, which does not affect enzyme activity nor ultrastructural appearance of cellular detail. The technique permits sectioning with an ordinary sliding microtome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00281098
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Arthroscopic lavage reduced the recurrence rate following primary anterior shoulder dislocation A randomised multicentre study with 1-year follow-up (1999)
    Springer
    Knee surgery, sports traumatology, arthroscopy 7 (1999), S. 192-196 
    Details
    ISSN: 1433-7347
    Keywords: Key words Shoulder ; Traumatic primary anterior dislocation ; Arthroscopic lavage ; Non-operative regime
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Notes: Abstract Young individuals have a high recurrence rate following non-operative treatment of traumatic primary anterior shoulder dislocation. The present multicentre study was undertaken to find out whether the results could be improved by using arthroscopic lavage as treatment. Sixty patients aged 16–30 years, with traumatic primary anterior shoulder dislocation were randomised into two groups. One group was treated with arthroscopic lavage within 10 days, while the other group was treated non-operatively. Rehabilitation was otherwise identical. At 1-year follow-up, 4 of 30 patients (13%) in the lavage group had had redislocation compared with 13 of 30 (43%) in the group treated non-operatively (P = 0.01).The difference in recurrence rate was more pronounced in younger patients. The functional outcome according to the Rowe shoulder score was better in the lavage group (P = 0.003), as was the anterior stability according to the apprehension test (P = 0.008). We conclude that arthroscopic lavage reduced the recurrence rate and produced a better functional outcome at 1-year follow-up than the non-operative treatment in young individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001670050146
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  • 8
    Electronic Resource
    Electronic Resource
    Sources of information, experiences and opinions on sexuality, contraception and STD protection among young Swedish students (1992)
    Springer
    Advances in contraception 8 (1992), S. 41-49 
    Details
    ISSN: 1573-7195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resumé L'objectif de la présente étude était d'examiner les sources d'information sur la sexualité, les contraceptifs et les MST chez les jeunes, ainsi que leurs expériences et leurs opinions dans ces domaines. Un questionnaire a été distribué à 192 élèves d'écoles secondaires dans la région de Stockholm. L'âge moyen des participants était de 17,4 ans. La majorité d'entre eux ont répondu au'ils trouvaient leurs meilleures sources d'information auprès des enseignants et dans des lectures personnelles. Les étudiantes avaient plus tendance à s'adresser à des amies et à des membres de la famille que leurs homologues masculins. Parmi ceux qui étaient déjà sexuellement actifs, bon nombre ont précisé que l'utilisation de préservatifs était difficile à pratiquer.
    Abstract: Resumen El objetivo de este estudio fue examinar las fuentes de información sobre la sexualidad, anticonceptivos y STD entre los jóvenes, así como sus experiencias y opiniones en estas cuestiones. Se distribuyó un cuestionario entre 192 alumnos secundarios de la región de Estocolmo. La edad media de los participantes era de 17,4 años. La mayoría de ellos manifestaron que sus mejores fuentes de información eran los profesores y las lecturas personales. Las estudiantes señalaban una mayor tendencia a consultar con amigas y con miembros de la familia que los estudiantes de sexo masculino. Entre los que ya tenían actividad sexual, un número considerable dijo que el uso de preservativos era difícil de practicar.
    Notes: Abstract The aim of the investigation was to study sources of information on sexuality, contraceptives and STDs among young people as well as their experiences of and opinions on the matter. A questionnaire was distributed to 192 high-school pupils in the Stockholm area. The mean age of the participants was 17.4 years. The majority stated that school teachers and individual reading are the best sources of information. Female students more often relied on friends and family members than male students. Among those who had had their sexual debut, many stated that condom use was hard to practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01849347
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    Paper (German National Licenses)
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