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  • 1
    Electronic Resource
    Electronic Resource
    Molecular structure and intramolecular motion of (E)-stilbenes in crystals. An interpretation of the unusually short ethylene bond (1992)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 114 (1992), S. 1041-1051 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00029a037
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Stereospecific and stereoselective reactions. I. Preparation of amines from alcohols (1972)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 94 (1972), S. 679-680 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00757a085
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of Chlorine Contents in Geological Survey of Japan Reference Materials by Prompt Gamma Neutron Activation Analysis (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Geostandards and geoanalytical research 28 (2004), S. 0 
    Details
    ISSN: 1751-908X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: We determined chlorine contents in nine GSJ (Geological Survey of Japan) reference materials (JB-1, 1a, 2, 3; JA-1, 2, 3; JR-1, 2) by prompt gamma neutron activation analysis, employing the standard addition method. Pressed powder disks of each reference material were used for neutron irradiation and gammaray measurement, after known quantities (25-200 μl) of sodium chloride solution were added. The influence of the nearby sodium peak overlap was checked, and fluctuations in the chlorine count rate were corrected using silicon as an internal standard. The slopes of calibration lines for seven reference materials (JB-1, 2, 3; JA-1, 2, 3; JR-2) and SiO2 powders fall within 5% error, and their chlorine values were obtained from the intercepts. Chlorine contents in JB-1 a and JR-1 were also determined by using the calibration lines. Our chlorine values ranged from 26.1 to 934 μg g-1, which agrees well with the previously reported values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1751-908X.2004.tb00762.x
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  • 4
    Electronic Resource
    Electronic Resource
    Detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients by using synthetic hinge peptide and glycopeptide probes (2004)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 9 (2004), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background and Aims:  There are many reports on the presence of an incompletely glycosylated O-linked oligosaccharide(s) on the IgA1 hinge region in some immunoglobulin (IgA) nephropathy patients. Furthermore, the production of an antibody against the naked hinge peptide portion was reported in an IgA nephropathy patient. In this report, characterization of the IgG antibody against the hinge portion was carried out by using synthetic hinge glycopeptide probes.Methods and Results:  The following synthetic hinge peptide and glycopeptides were prepared: 19mer peptide, V-P-S-T-P-P-T-P-S-P-S-T-P-P-T-P-S-P-S (designated HP), the peptide having a single α-linked GalNAc residue at positions 4, 7, 9, 11 and 15 (4 GN − 15 GN, respectively) and the same peptide having five GalNAc residues at all five positions (GN5). The mean value of the antibody activity against these probes was compared with each other. The highest activity against the naked hinge peptide (HP) and lowest activity against the fully glycosylated hinge peptide (GN5) were obvious. As attachment of GalNAc to position 4 or 11 on the peptide brought about a significant reduction of the activity against the naked hinge peptide, the P-S-T-P sequence included in both positions was thought to be the most probable site recognized by these antibodies. As an additional unexpected observation, a gender difference in this antibody activity against all the probes was found. The antibody activity in a female was significantly higher compared with that in a male.Conclusion:  Because the frequency of incidence of IgA nephropathy is known to be slightly higher in males, this gender difference might indicate a protective meaning to remove aberrantly glycosylated molecules from the patient's serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.2003.00225.x
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  • 5
    Electronic Resource
    Electronic Resource
    Steroid therapy in progressive IgA nephropathy: A 10 year follow-up study (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 3 (1997), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: This study was undertaken in order to evaluate the effect of steroid therapy on the long-term clinical course in progressive IgA nephropathy with persistent massive proteinuria of ≤ 1.0 g/day. From 1972 to 1986, 109 patients with persistent massive proteinuria who were continuously followed up during a 10 year period. Seventy-seven of these patients had moderate proteinuria of 1-2 g/day and the remaining 32 patients had heavy proteinuria of more than 2 g/day. the 109 patients were divided into three groups according to the grade of renal function and histological severity: group 1 (58 cases), preserved renal function (creatinine clearance rate [Ccr] ≤ 70 mL/min) and moderate to severe histology (total score ≤ 7); group 2 (35 cases), decreased renal function (Ccr 〉70 mL/min) and moderate to severe histology; and group 3 (16 cases), preserved renal function and mild histology (total score ≥ 6). Fifty-five patients received steroid therapy for 2 years, followed by an anti-platelet drug therapy until the completion of the study. Fifty-four patients were treated with only an anti-platelet drug therapy for the duration of the study. There were no significant differences in renal function and renal survival rates over the 10 year period between the steroid-treated and the non-steroidtreated groups. Among the moderately proteinuric patients of group 1, the 20 steroid-treated patients showed significantly favourable clinical courses compared to the 26 non-steroid-treated patients of the same group. the 12 heavily proteinuric, steroid-treated patients of the group 1 also showed significantly favourable courses compared to those 26 moderately proteinuric, non-steroid patients. However, all but one patient in group 2, (with and without steroid therapy) went into end-stage renal failure within the 10 year follow-up period. These results indicate that corticosteroid treatment has a long-term beneficial effect for the stabilization of renal function in progressive IgA nephropathy with massive proteinuria ≤ 1.0 g/day, when patients have preserved renal function of 70 mL/min or more in initial Ccr values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.1997.tb00294.x
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