ISSN:
0897-3806
Keywords:
microvasculature
;
capillary plexus
;
grafts
;
intestinal
;
Life and Medical Sciences
;
Miscellaneous Medical
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
To examine the microvascular changes of villi after transplantation, the small intestine was transplanted in 36 Wistar/Shi rats (16 syngeneic, 20 allogeneic; donor Lewis). At days 1, 4, 8, and 10, four rats of the syngeneic group and five of the allogeneic group were killed. Corrosion casts of the vessels of the graft were prepared and examined by scanning electron microscopy. In the grafts of each group at 1 day, the villous microvascular casts were reduced in height, and the capillary plexus was much less dense, with signs of degeneration. By 4 days, however, the villi of syngeneic grafts had been restored to normal, both in their dimensions and in the richness of the capillary plexus. On the other hand, the microvascular casts of allografts at the same stage showed the villi still to be greatly reduced in height, although the density of the capillary net had been restored essentially to normal. At 8 and 10 days, the allogeneic grafts again showed short villi, but with greatly reduced capillary networks, Our results suggest that the regeneration of intestinal villi following ischemic damage at operation is rapid in syngeneic grafts and that in allogeneic grafts the processes of rejection had started by 4 days. © 1992 Wiley-Liss, Inc.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ca.980050505
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