ZIB

Hits per page

hit 1 - 1 | 1 hit

Sorting

Electronic Resource

Modulation of TGF-β1 production from human keratinocytes by UVB (1997)

Lee, Hyung-Suk T. ; Kooshesh, Fatemeh ; Saunder, Daniel N. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Experimental dermatology 6 (1997), S. 0

add to mindlist on the mindlist

Details

ISSN: 1600-0625

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract Transforming growth factor-β (TGF-β) plays an important role not only in cell growthasontrol but also in inflammation and immunoregulation. There are at least five different isoforms of TGF-β. TGF-β1 has a large variety of biological functions including the modulation of inflammation and the immune system and has most extensively been studied in skin. Since ultraviolet B (UVB) is known to induce skin erythema and immunosuppression. we sought to examine whether UVB would alter the expression and production of TGF-β1 in normal human keralinocytes. Using reverse transcription-polymerase chain reaction (RT-PCR). constitutive expression of TGF-β1 mRNA was detected in keralinocytes and the level of TGF-β1 mRNA was increased 4 and 8 h after 300 J/m2 UVB irradiation. Production of TGF-β1 protein in culture supernatants assayed by ELISA was also increased at 24 h after irradiation. Cycloheximide treatment blocked this TGF-β1 protein induction indicating de novo protein synthesis of TGF-βl from keratinocytes induced by UVB. These results suggest a possible role for TGF-β1 in UVB-induced skin inflammation and immunosuppression.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1600-0625.1997.tb00155.x

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

hit 1 - 1 | 1 hit