ISSN:
1435-1803
Schlagwort(e):
Ca2+ overload
;
myocardium
;
antiinflammatory drugs
;
antioxidants
;
after-contractions
;
lipid peroxidation
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Ca2+ overload followed by after-contractions was induced by perfusion of mammalian papillary muscles with O−K 0 + , high Ca2+ solution. The effect of lipotrophic agents (dexamethasone, indomethacin) or free radical scavengers (α-tocopherol, reduced glutathione, synthetic antioxidant) was tested at different stages of Ca2+ overloading processes. All the agents tested proved to be effective in attenuating the after-contractions. Activation of lipid peroxidation has been suggested as one of the possible molecular events underlying mechanical destabilization of Ca2+-overloaded myocardium.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01908177
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