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  • 1
    Electronic Resource
    Electronic Resource
    A genome-wide survey of RAS transformation targets (2000)
    [s.l.] : Nature America Inc.
    Nature genetics 24 (2000), S. 144-152 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] An important aspect of multi-step tumorigenesis is the mutational activation of genes of the RAS family, particularly in sporadic cancers of the pancreas, colon, lung and myeloid system. RAS genes encode small GTP-binding proteins that affect gene expression in a global way by acting as major ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/72799
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  • 2
    Electronic Resource
    Electronic Resource
    Suppression of the neoplastic phenotype and “anti-oncogenes” (1987)
    Springer
    Annals of hematology 54 (1987), S. 257-265 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320871
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  • 3
    Electronic Resource
    Electronic Resource
    The gene encoding the Ia-Associated invariant chain is located on chromosome 18 in the mouse (1985)
    Springer
    Immunogenetics 21 (1985), S. 83-90 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (la) was determined by Southern blot analysis of DNA from a panel of mouse x Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse Ii cDNA as a hybridization probe, we localized the gene coding for the invariant chain to mouse chromosome 18.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372244
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  • 4
    Electronic Resource
    Electronic Resource
    New amino acids, and heterocyclic compounds participating in the stickland reaction of Clostridium sticklandii (1973)
    Springer
    Archives of microbiology 93 (1973), S. 267-276 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The Stickland reaction was studied in suspensions of starved cells of Clostridium sticklandii with the aid of NADH fluorescence, and enzymic determinations of NADH. 1. Cells of C. sticklandii can be starved by anaerobic incubation with a hydrogen-accepting substrate, such as glycine or proline. 2. Arginine or formate, known reductants of C. sticklandii cause a rapid reduction of NAD in starved cells, which is reversed upon the addition of oxidants, such as glycine or proline. 3. New reductants in the Stickland reaction of this organism are alanine, serine, and threonine, as they cause a marked increase of NADH fluorescence in starved cells. 4. New oxidants are glutamate, histidine, adenine, uracil, thymine, uric acid, and xanthine, as established by the reverse criterion, the decrease of the NADH fluorescence of starved cells previously reduced with an optimal reductant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412026
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  • 5
    Electronic Resource
    Electronic Resource
    Degradation of pyrimidine bases in Clostridium sticklandii (1980)
    Springer
    Archives of microbiology 124 (1980), S. 111-114 
    Details
    ISSN: 1432-072X
    Keywords: Pyrimidine degradation ; Pyrimidine uptake ; Thymine ; Uracil ; Dihydrothymine ; Dihydrouracil ; β-Ureidoisobutyrate ; Stickland reaction ; Clostridium sticklandii
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Resting cells of Clostridium sticklandii took up thymine or uracil, when grown in a medium containing 40 mM serine and 20 mM thymine or uracil. The uptake was much lower, when the cells had been grown in a complex medium. Cell-free extracts from cells grown in the complex medium reduced the two bases to the dihydro compounds and decomposed dihydrothymine to β-ureidoisobutyrate, as indicated by thin-layer chromatography. Uptake and degradation were stimulated by both NADH and NADPH. Further breakdown did not occur, as 14CO2 was not evolved from C-2-labelled thymine or uracil. The rates of pyrimidine uptake and breakdown of C. sticklandii were lower than those reported for C. sporogenes (Hilton et al., 1975).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00407038
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  • 6
    Electronic Resource
    Electronic Resource
    DNA-mediated transfer of the mouse gene for hypoxanthine phosphoribosyltransferase into cultured mouse cells: No integration of the transferred gene at its homologous site in the host genome (1981)
    Springer
    Molecular genetics and genomics 182 (1981), S. 70-76 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary An established Chinese hamster cell line was fused with microcells isolated from phenotypically stable transferent mouse cells which contained a mouse transgenome coding for an abnormal form of mouse hypoxanthine phosphoribosyltransferase (HPRT, EC. No. 2.4.2.8) (Willecke et al. 1979). Two hybrids were isolated which expressed the abnormal form of mouse HPRT but no mouse α-galactosidase (GALA, EC. No. 3.2.1.22). In one of these microcell hybrids the abnormal HPRT activity segregated under counter-selective conditions with mouse chromosome 3. No mouse chromosome or additional mouse gene marker was found in the second microcell hybrid, possibly because of breakage and/or rearrangement of the integrated transgenome during the isolation of this hybrid. We conclude from these results that the transferred mouse HPRT gene in a phenotypically stable clone is not integrated at its homologous site on the host X chromosome. Rather, the transgenome is probably integrated into mouse chromosome 3, possibly due to homologies in repeated DNA sequences which may occur in the transgenome and which are interspersed at many sites in the host genome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422769
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  • 7
    Electronic Resource
    Electronic Resource
    The Ha-ras-induced transformed phenotype of Rat-1 cells can be suppressed in hybrids with rat embryonic fibroblasts (1987)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 34 (1987), S. 23-30 
    Details
    ISSN: 0730-2312
    Keywords: cellular hybrids ; tumor suppression ; Harvey-ras oncogene ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Somatic cell hybrids were isolated from fusions of diploid embryonic rat fibro-blasts with transformed Rat-1 cells which contained 4 to 5 copies of the transforming human Ha-ras 1 gene. In contrast to their transformed parental cells four hybrid clones showed normal morphology, long latency periods of tumorigenicity in newborn rats, anchorage requirement of proliferation, and an eightfold-reduced amount of secreted transforming growth factor activity. Thus these hybrids are called suppressed with regard to expression of the Ha-ras-induced transformed phenotype. Tumorigenic derivatives of the suppressed hybrids that had segregated chromosomes were isolated. Since two of the tumorigenic hybrid clones showed the similar low level of secreted transforming growth factors as the suppressed hybrids, decreased production of transforming growth factor activity is unlikely to be a sufficient criterion for suppression of malignancy. Whereas one of the suppressed hybrids expressed the transforming gene product p21 at a level similar to that of the transformed parental cells, other suppressed hybrids expressed less p21. This suggests that the suppressed phenotype can be regulated at the posttranslational level of p21 but that additional controls of expression of p21 are likely to exist. DNA of the suppressed hybrids transformed Rat-1 cells to proliferation in the presence of semisolid agar. Thus the activated human Ha-ras gene in the suppressed hybrids retained its biological activity even though it did not transform these cells to tumorigenicity.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240340104
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