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  • 1
    Electronic Resource
    Electronic Resource
    Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms (1995)
    Springer
    Diabetologia 38 (1995), S. 757-763 
    Details
    ISSN: 1432-0428
    Keywords: Key words Human insulin ; porcine insulin ; brain ; insulin receptor ; insulin degradation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous studies have suggested that human and porcine insulin exert identical effects on blood glucose and counter-regulatory hormones but elicit different neurophysiological reactions. A major goal of the present study was to investigate whether this could be caused by different relative affinities of the insulins from different species to insulin receptors from the brain compared to other tissues. Insulin receptors isolated from human brain, muscle or adipocytes as well as from cultured cells over-expressing either of the human insulin receptor isoforms (exon 11– or exon 11 + ) were immobilized to microwells coated with monoclonal anti-insulin receptor antibody. Subsequently the binding of human, porcine and bovine insulin was measured. While the receptors derived from the different tissues had different affinities for insulin, there were no tissue-specific differences in the relative binding of the insulins of the three species. The insulins of the three species were also not different with regard to their binding to the receptor isoforms. Finally, in human brain homogenates no differences in the degradation rates for human, porcine and bovine insulin were detected. Thus, our data do not support the hypothesis that different neurophysiological reactions during hypoglycaemia due to human or porcine insulin are caused by differences of the binding of the insulins to human brain insulin receptors or their degradation in the human brain. [Diabetologia (1995) 38: 757–763]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050349
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  • 2
    Electronic Resource
    Electronic Resource
    The HIV-1 protease inhibitor indinavir impairs insulin signalling in HepG2 hepatoma cells (2000)
    Springer
    Diabetologia 43 (2000), S. 1145-1148 
    Details
    ISSN: 1432-0428
    Keywords: Keywords HIV protease inhibitors ; lipodystrophy syndrome ; diabetes mellitus ; insulin resistance ; insulin signalling.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Patients treated with human immunodeficiency virus-1 protease inhibitors often develop impaired glucose tolerance or diabetes, most likely due to an induction of insulin resistance. We therefore investigated whether the protease inhibitor indinavir alters insulin signalling. Methods. We incubated HepG2 cells for 48 h without or with indinavir (100 μmol/l). Subsequently 125I-insulin binding to the cells and the effects of insulin stimulation on insulin-receptor substrate-1-phosphorylation, association of phosphatidylinositol 3-kinase with insulin-receptor substrate-1 and Akt-Thr308-phosphorylation were measured. Results. In cells not exposed to indinavir, insulin (100 nmol/l) led to rapid increases of insulin-receptor substrate-1-phosphorylation, association of phosphatidylinositol 3-kinase with insulin-receptor substrate-1 and Akt-phosphorylation during the first 75 s, followed by subsequent decreases. In indinavir-treated cells, these insulin-stimulated increases during the first 75 s were reduced by 30–60 % and this was not associated with alterations in cell number or viability, insulin binding to the cells or cellular insulin-receptor substrate-1-content. Conclusion/interpretation. Effects of indinavir on initial insulin signalling could cause, or contribute to, the metabolic effects of human immunodeficiency virus-1 protease inhibitors. [Diabetologia (2000) 43: 1145–1148]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051505
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  • 3
    Electronic Resource
    Electronic Resource
    N -Methyl- N -Nitrosourea as a Strong Topical Carcinogen when painted on Skin of Rodents (1967)
    [s.l.] : Nature Publishing Group
    Nature 214 (1967), S. 611-611 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] After completely negative results with diethylnitros-amine4 on the mouse skin we obtained positive results with N-methyl-N-nitrosourea (MNU) on the same animals5. In this communication a strong carcinogenic action of MNU on the skin of Syrian hamsters and rats, administered by painting, is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/214611a0
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  • 4
    Electronic Resource
    Electronic Resource
    Coexistence of factor V Leiden and primary antiphospholipid syndrome: a patient with recurrent myocardial infarctions and thrombocytopenia (2000)
    Springer
    Zeitschrift für Kardiologie 89 (2000), S. 1067-1071 
    Details
    ISSN: 1435-1285
    Keywords: Schlüsselwörter Koronare Herzerkrankung – Resistenz gegen aktiviertes Protein C – Faktor V Leiden – Antiphospholipid-Syndrom ; Key words Coronary artery disease – activated protein C resistance – factor V Leiden – antiphospholipid syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Increased thrombin generation associated with resistance to activated protein C makes the latter a likely candidate for an increased risk of acute coronary events. Activated protein C resistance (factorV Leiden) on its own, however, appears to have no significant effect in this regard. We describe a case of recurrent myocardial infarction caused by coronary thrombosis in a patient with persistent thrombocytopenia who was found to have a coexistence of heterozygous factor V Leiden and primary antiphospholipid syndrome. Since both thrombophilic disorders interfere with the protein C anticoagulant system, the simultaneous existence of inherited and acquired resistance against activated protein C could account for an increased thrombophilia with manifestation in the coronary arteries. This case suggests that evaluation of patients who present with recurrent acute coronary events should also consider these coagulation defects.
    Notes: Zusammenfassung Eine verminderte Inhibitorwirkung des aktivierten Protein C und die daraus resultierende übermäßige Entstehung von Thrombin könnte zu einem erhöhten Risiko für akute koronare Ereignisse führen. Eine angeborene Resistenz gegen aktiviertes Protein C (Faktor-V-Leiden) allein scheint jedoch keinen Risikofaktor für Myokardinfarkte darzustellen. Wir berichten über einen Patienten mit chronischer Thrombozytopenie und rezidivierenden Myokardinfarkten infolge koronarer Thrombosen, bei dem eine Koexistenz von heterozygotem Faktor V Leiden und primärem Antiphospholipid-Syndrom diagnostiziert wurde. Da beide thrombophilen Erkrankungen mit dem Protein C System interferieren, könnte eine erhöhte Thromboseneigung mit Manifestation in den Koronargefäßen auf das gleichzeitige Vorliegen einer angeborenen und erworbenen Resistenz gegen aktiviertes Protein C zurückzuführen sein. Der Fallbericht weist darauf hin, dass Patienten mit rezidivierenden akuten Koronarereignissen auch hinsichtlich des Vorliegens dieser Gerinnungsstörungen untersucht werden sollten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003920070133
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  • 5
    Electronic Resource
    Electronic Resource
    Automatic methods for the determination of total dissolved and particulate carbohydrates in the marine environment (1986)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 323 (1986), S. 47-49 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary The methods recommended for the determination of total dissolved and particulate carbohydrates in the marine environment are based on the l-tryptophan/sulfuric acid reaction. Automatic measurements are performed with a Technicon AutoAnalyzer II. Glucose is used for the calibration procedure. Interfering nitrate and nitrite are also measured with a Technicon AutoAnalyzer II; the values are subtracted from the total reading of the carbohydrate analyzer after calibration. Particulate carbohydrates are measured after sulfuric acid digestion of the residue on glassfiber filters. Both methods permit total carbohydrates to be determined exactly in the concentration range from 0.1–30 μmol/l.
    Notes: Zusammenfassung Die für die Bestimmung gelösten und partikulären Gesamt-Kohlenhydrats in Seewasser empfohlenen Methoden basieren beide auf der l-TryptophanSchwefelsäure-Reaktion. Die Messungen erfolgen automatisch im Technicon AutoAnalyzer II. Zur Eichung wird Glucose benutzt. Störendes Nitrat und Nitrit werden ebenfalls mit einem Technicon AutoAnalyzer II gemessen; die entsprechenden Werte werden nach Eichung vom Gesamtsignal des Zuckeranalysators abgezogen. Partikuläre Kohlenhydrate werden nach Aufschluß des Rückstandes auf Glasfaserfiltern mit Schwefelsäure gemessen. Beide Methoden liefern genaue Ergebnisse im Bereich von 0.1–30 μmol/l.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00531130
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitative determination of norepinephrine and epinephrine in human urine by HPLC with electrochemical detection (1982)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 311 (1982), S. 423-424 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Conclusion HPLC-ED proved to be a practicable method for the differential assay of urinary NE and E with high precision, accuracy and specificity; for clinical laboratories it should be considered as control method and alternative for traditional fluorescence assays. The method can be easily extended to the simultaneous determination of urinary dopamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00481787
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  • 7
    Electronic Resource
    Electronic Resource
    Nucleoside von Fluorzuckern. IX. Synthese von Fluorzucker-Nucleosiden aus Uridin und Cytidin (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 251-265 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch nucleophile Substitution der Tosyloxy-Gruppe von 2′,3′-O-Isopropyliden-5′-O-tosyl-uridin 2 durch Fluor mittels Kaliumfluorid in Äthylenglykol wird 5′-Desoxy-5′-fluor-2′,3′-O-isopropyliden-uridin 3 erhalten, von dem ausgehend eine Reihe neuer biochemisch interessanter, im Zuckerteil fluorsubstituierter Ribo- und Arabino-Nucleoside des Uracils, 5-Brom- und 5-Joduracils und des Cytosins dargestellt werden. 5′-Desoxy-5′-fluor-cytidin 20 wird außerdem (in mehreren Stufen) aus Cytidin erhalten.Der Reaktionsmechanismus der Umsetzung von 2 mit Kaliumfluorid in Äthylenglykol wird näher untersucht und die Struktur eines Nebenproduktes 5 beschrieben.Von den untersuchten Verbindungen zeigt insbesondere 1-(5-Desoxy-5-fluor-β-D-arabinofuranosyl)-5-bromuracil 14 signifikante Hemmwirkungen auf das Enzym Thymidylat-Kinase.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140207
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