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  • 1
    Electronic Resource
    Electronic Resource
    A matter of terminology-Beispiele aus der Kulturlandschaft des arabisch-islamischen Nordafrika
    Amsterdam : Elsevier
    Geoforum 7 (1976), S. 80-85 
    Details
    ISSN: 0016-7185
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geography
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0016-7185(76)90062-2
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  • 2
    Electronic Resource
    Electronic Resource
    Safety assessment for polyetherol production using reaction kinetic data
    Amsterdam : Elsevier
    Thermochimica Acta 225 (1993), S. 189-199 
    Details
    ISSN: 0040-6031
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6031(93)80187-F
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  • 3
    Electronic Resource
    Electronic Resource
    Gas evolution and pressure increase during undesirable chemical reactions - A survey of the experimental methods to detect gas evolution and pressure increase
    Amsterdam : Elsevier
    Thermochimica Acta 225 (1993), S. 239-250 
    Details
    ISSN: 0040-6031
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6031(93)80191-C
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  • 4
    Electronic Resource
    Electronic Resource
    Phenolic substrates for fluorometric detection of laccase activity (1997)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 153 (1997), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A fluorometric procedure has been developed for detection and estimation of laccase activity in fungal broth cultures. Laccase solution was pretreated with catalase for 1 h at 37°C and pH 5. Homovanillic acid was then added and the reaction mixture incubated for a further hour at 37°C. The fluorescence was then developed by addition of 0.1 M glycine buffer at pH 10. Laccase preparations from Pyricularia oryzae, Coriolus hirsutus and Pycnoporus cinnabarinus catalysed formation of a fluorescent product of HVA but the optimum pH values of enzyme activities varied. The culture fluids of several other fungi also catalysed development of fluorescence in solutions containing HVA. p-Hydroxyphenylacetic acid was a poor substrate for all laccases in vivo except that produced by Perennipora tephropora.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1997.tb12614.x
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of bone healing in patients with bone grafts and endosseous implants using single photon emission tomography (SPECT) (1998)
    Copenhagen : Munksgaard International Publishers
    Clinical oral implants research 9 (1998), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of the present study was to evaluate the healing of onlay grafts to edentulous jaws in conjunction with osseointegrated implants using single photon emission computed tomography (SPECT). In all, 24 patients were examined who had received 26 full arch onlay grafts for augmentation of extremely atrophic edentulous jaws with secondary placement of implants 21.4 weeks after grafting. 99mTechnetium-MDP scintigrams were performed immediately after grafting. before implant placement, after implant placement and before abutment connection. Tracer accumulation was assessed semiquantitatively by calculating ratios of count densities between the up-take over the calvarium and over the grafted jaws based on 16 regions of interest in the reconstructed tomograms corresponding to 16 possible areas of implant placement. There was a significant decrease in tracer uptake during graft healing, which was followed by a significant increase after implant placement and a subsequent decrease during implant healing. In 3 patients, infection and partial necrosis of the grafted bone occurred. In these cases, tracer uptake in areas of subsequent graft infection immediately after grafting was significantly lower compared to patients with uneventful healing as a sign of inferior graft revascularization. In 3 patients, 14 implants failed due to mobility at the time of abutment connection or loss of osseointegration within the first weeks thereafter. Significantly lower levels of tracer up-take immediately after grafting and during graft healing were found in these areas, representing a lack of bone turnover due to decreased revascularization. These areas also showed a lower increase in tracer accumulation after implant placement due to the inferior graft quality, followed by a significant increase of periimplant bone turnover at the time of abutment connection representing inflammatory periimplant bone reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.1998.090105.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of donor characteristics, technique of harvesting and in vitro processing on culturing of human marrow stroma cells for tissue engineered growth of bone (2005)
    Oxford, UK : Munksgaard International Publishers
    Clinical oral implants research 16 (2005), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The aim of this study was to assess the effect of donor characteristics and the technique of harvesting and in vitro processing on the efficacy of culturing of human mesenchymal stem cells (hMSCs) for tissue engineered growth of bone. Cultures of hMSCs were derived from iliac crest bone marrow aspirates (21 donors, age 11–76) and from cancellous bone grafting material (32 donors, age 13–84). Age had no significant effect on the ability to isolate and culture hMSCs, although the failure rate was 55.6% in donors beyond the age of 60, while it varied between 14.3% and 22.2% in donors under 60 years of age. Male and female donors had comparable failure rates (27.3% and 28.6%, respectively). Culturing of hMSCs was successful in 90.4% of marrow aspirates from 21 donors and in 62.5% of cancellous bone specimens from 35 donors. This difference was statistically significant (P=0.023). Regression analysis confirmed that at simultaneous testing of the three variables, only the source of cells significantly affected the result (P=0.043). Morphological evaluation of the unfractionated primary population showed a change in cell shape of the adherent cells from a triangular into thin spindle-shaped elongated form, which remains until confluence. When the cultures were exposed to osteoinductive medium, various morphotypes expressing different levels of alkaline phosphatase and secreting different amounts of mineral were evident. Morphology of marrow stroma cells (MSCs) from marrow aspirates was not different from MSCs derived from cancellous bone specimens. Expression of osteogenic markers in MSCs as shown by PCR as well, did not differ between the two sources. It is concluded that marrow aspirates and cancellous bone specimens produce comparable populations of MSCs. However, bone marrow aspirates from donors under the age of 60 years rather than cancellous bone chips are favourable for isolation and expansion of hMSCs for tissue engineered growth of bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0501.2005.01142.x
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  • 7
    Electronic Resource
    Electronic Resource
    Osseointegration of titanium fixtures in onlay grafting procedures with autogenous bone and hydroxylapatite. An experimental histometric study. (1991)
    Copenhagen : Munksgaard International Publishers
    Clinical oral implants research 2 (1991), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of the present study was to determine the degree of osseointegration of fixtures in different onlay grafting materials. Hydroxylapatite blocks of 2 different pore sizes and free monocortical bone grafts from the iliac crest were inserted in Gijttingen minipigs and fixed with 2 titanium fixtures. The extent of the bone/implant interface area on the fixture surface was determined from histological specimens by morphometric measurements and related to the total thread surface of the fixtures. Fixtures inserted into bone grafts showed the most complete degree of osseointegration, whereas the smallest bone/implant interface area was found with fixtures inserted into those HA blocks with the smaller pore size. There was a significant decrease in the degree of osseointegration between the host bone site and the augmentation material only with the fixtures inserted into the HA blocks of smaller pore size.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.1991.020202.x
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation (2005)
    Oxford, UK : Munksgaard International Publishers
    Clinical oral implants research 16 (2005), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The aim of the present study was to test the hypothesis that immobilization of bone morphogenic protein (BMP2) on the surface of titanium implants can enhance peri-implant bone formation. Ten adult female foxhounds received experimental titanium screw implants in the mandible 3 months after removal of all premolar teeth. Three types of implant surfaces were evaluated in each animal: (i) implants with machined titanium surface, (ii) implants coated with collagen I, (iii) implants coated with collagen I, chondroitin sulphate (CS) and BMP2. Peri-implant bone regeneration was assessed using histomorphometry after 1 and 3 months in five dogs each by measuring bone–implant contact (BIC) and the volume density of the newly formed peri-implant bone (BVD). After 1 month, there was no significant enhancement in BIC values but volume density of the newly formed peri-implant bone was significantly higher in the two groups of coated implants. No significant difference was found between collagen and BMP2 coating. After 3 months, BIC was significantly higher in both collagen and BMP2-coated implants compared with implants with machined surfaces. Peri-implant BVD was also significantly increased in coated implants in comparison with machined surfaces. It was concluded that collagen coating of dental screw implants can enhance BIC and peri-implant bone formation. Addition of BMP2 does not increase peri-implant bone formation in the present application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0501.2005.01143.x
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  • 9
    Electronic Resource
    Electronic Resource
    Use of a mineralized collagen membrane to enhance repair of calvarial defects in rats (2004)
    Oxford, UK : Munksgaard International Publishers
    Clinical oral implants research 15 (2004), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The aim of the present study was to evaluate mineralized collagen membranes for enhancement of bone regeneration in calvarial defects. Forty adult female Sprague–Dawley rats received calvarial full thickness defects with a diameter of 8 mm. In 20 animals, the defects were covered with a mineralized collagen membrane, and 20 animals served as controls. After 6, 13, 26 and 52 weeks, bone regeneration was evaluated using undecalcified thick-section histometry. There was no clear enhancement of bone regeneration during the first 26 weeks after the operation. Bone regeneration underneath the membrane produced consistently thicker bone, albeit without statistical significance. Accumulation of membrane material occurred in the center of the defects surrounded by multinuclear giant cells during early stages of healing. After complete resorption of the membrane, significantly increased bone formation was seen after 52 weeks in the defects that had received membrane coverage. It was concluded that mineralization in the present form did not increase mechnical strength of the membrane to prevent interference of the membrane with bone regeneration in the defect. The reason for the increase in bone formation after resorption of the membrane after 26 weeks remains to be clarified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0501.2004.00992.x
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of RGD peptide coating of titanium implants on periimplant bone formation in the alveolar crest (2002)
    Oxford, UK : Blackwell Science, Ltd
    Clinical oral implants research 13 (2002), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The aim of the present study was to analyse the effect of organic coating of titanium implants on periimplant bone formation and bone/implant contact. Three types of implants were used: (i) Ti6Al4V implants with polished surface (control 1) (ii) Ti6Al4V implants with collagen coating (control 2) (iii) Ti6Al4V implants with collagen coating and covalently bound RGD peptides. All implants had square cross-sections with an oblique diameter of 4.6 mm and were inserted press fit into trephine burr holes of 4.6 mm in the mandibles of 10 beagle dogs. The implants of five animals each were evaluated after a healing period of 1 month and 3 months, during which sequential fluorochrome labelling of bone formation was performed. Bone formation was evaluated by morphometric measurement of the newly formed bone around the implant and the percentage of implant bone contact. After 1 month there was only little bone/implant contact, varying between 2.6 and 6.7% in the cortical bone and 4.4 and 5.7% in the cancellous bone, with no significant differences between the three types of implants. After 3 months, implants with polished surfaces exhibited 26.5 and 31.2% contact in the cortical and cancellous bone, respectively, while collagen-coated implants had 19.5 and 28.4% bone contact in these areas. Implants with RGD coating showed the highest values with 42.1% and 49.7%, respectively. Differences between the surface types as such were not significant, but the increase in bone/implant contact from 1 to 3 months postoperatively was significant only in the group of RGD-coated implants (P = 0.008 and P = 0.000). The results of this pilot study thus provide only weak evidence that coating of titanium implants with RGD peptides in the present form and dosage may increase periimplant bone formation in the alveolar process. The results therefore require further verification in a modified experimental setting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.2002.130312.x
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