ISSN:
1432-0428
Keywords:
Key words Diabetic neuropathy
;
nerve blood flow
;
vasodilator
;
sciatic nerve
;
cilostazol.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Two proposed mechanisms of diabetic neuropathy are microvascular ischaemia and a reduction in Na,K-ATPase activity. We evaluated the effect of cilostazol, a drug that is both a potent phosphodiesterase inhibitor that normalizes nerve Na,K-AT-Pase and a vasodilator, on nerve blood flow (NBF) to determine whether it would improve experimental diabetic neuropathy. We examined whether epineurally applied cilostazol acted as a vasodilator on the peripheral nerve of normal and diabetic rats, and whether feeding the rats a cilostazol-supplemented diet could improve diabetic neuropathy. Cilostazol increased nerve blood flow (NBF) in a dose-dependent fashion with an EC50 of 10–5.74 mol/l. Cilostazol also normalized NBF in experimental diabetic neuropathy with a 10–4 mol/l local application on the sciatic nerve. In diabetic neuropathy, a cilostazol-supplemented diet improved both NBF and nerve conduction in a dose- and time-dependent fashion. Potential mechanisms of action of cilostazol on the nerve include its effect on NBF, Na, K-ATPase, and restoration of the thromboxane:prostacyclin ratio. Cilostazol may have potential in the treatment of diabetic neuropathy. [Diabetologia (1995) 38: 914–918]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00400579
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