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  • 1
    Electronic Resource
    Electronic Resource
    Kinetic study of the hydration mechanism of vitamin B6 and related compounds (1970)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 92 (1970), S. 6134-6139 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00724a006
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  • 2
    Electronic Resource
    Electronic Resource
    Carcinoembryonales Antigen (CEA) und CEA-like Aktivität in Ascites und Pleuraergüssen (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 575-579 
    Details
    ISSN: 1432-1440
    Keywords: Carcinoembryonic antigen (CEA) ; Carcinoembryonales Antigen (CEA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das carcinoembryonale Antigen (CEA) wurde in 18 nicht-malignen und 21 malignen Ergüssen bestimmt. In 95% der benignen Ergüsse lag es im Normbereich und war lediglich in einem Fall bei Klebsiellen-Pneumonie erhöht. Von den 21 malignen Ergüssen war das CEA in 57% der Fälle erhöht und in 4 Fällen war der erhöhte Titer erster Hinweis auf die Malignität des Ergusses. Teilweise bestehen erhebliche Unterschiede in der Titerhöhe zwischen Erguß und Serum. Die gleichzeitige Bestimmung des carcinoembryonalen Antigens in Erguß und Serum erhöht die diagnostische Aussagekraft.
    Notes: Summary Carcinoembryonic antigen (CEA) was assayed in 18 samples of non-malignant and 21 samples of malignant effusions. In 95% of benign effusion CEA activity was found within normal limits and increased only in one case of Klebsiella pneumonia. In 57% of the 21 malignant effusions CEA levels were elevated and in 4 cases elevated titers were first indications of the malignancy of the effusion. In some cases remarkable differences between serum titer and effusion titer were found. Combined measurement of CEA activity in plasma and effusion increases diagnostic value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01491136
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  • 3
    Electronic Resource
    Electronic Resource
    Stages of emerging life —Five principles of early organization (1982)
    Springer
    Journal of molecular evolution 19 (1982), S. 47-61 
    Details
    ISSN: 1432-1432
    Keywords: Prebiotic evolution ; Polynucleotide replication ; Quasispecies ; Hypercycles ; Compartmentalization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Five principles underly the evolution of the genetic language: formation of stereoregular heteropolymers, selection through self-replication, evolution of quasispecies towards optimal structures, regulated cooperation between competitors through catalytic hypercycles and evaluation of translation products through compartmentalization. These principles are formulated and illustrated by means of experimental results
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02100223
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  • 4
    Electronic Resource
    Electronic Resource
    Proton transfer reactions in aqueous solutions of pyridoxamine phosphate (1988)
    Springer
    European biophysics journal 16 (1988), S. 219-229 
    Details
    ISSN: 1432-1017
    Keywords: Relaxation kinetics ; ultrasound absorption ; temperature jump ; proton transfer ; vitamin B 6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract UV-visible and 13C NMR measurements described in the literature and our 31P NMR measurements support the following mechanism of proton transfer reactions in aqueous solutions of pyridoxamine phosphate: Only the tautomeric equilibrium between neutral form, A N, and zwitterion, A Z, which is analogous to the tautomeric equilibrium of 3-hydroxypyridine in aqueous solution, is important, and that equilibrium does not change upon the dissociation of the second phosphate proton. With these simplifying assumption, we have simulated the relaxation spectrum of the proton transfer reactions of pyridoxamine phosphate in water using parameters from analogous reactions and compared it with our ultrasound and temperature jump measurements. We have found that the relaxation process measured by the temperature jump experiment is mainly caused by the overall reaction A N=A Z (or A N - =A Z - ) and the ultrasound absorption at the isoelectric point between pK2 and pK3 is mainly caused by the overall reaction $$A^{\text{ + }} + {\text{x}} A_N^ - + \left( {1 - {\text{x}}} \right)A_Z^ - = {\text{y}}A_N + \left( {2 - {\text{y}}} \right)A_Z , 0 \leqq {\text{x}} \leqq {\text{1,}} {\text{0}} \leqq {\text{y}} \leqq 2$$ .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261264
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  • 5
    Electronic Resource
    Electronic Resource
    RNA multi-structure landscapes (1993)
    Springer
    European biophysics journal 22 (1993), S. 13-24 
    Details
    ISSN: 1432-1017
    Keywords: Fitness landscapes ; Partition function ; Quasispecies ; RNA secondary structures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Statistical properties of RNA folding landscapes obtained by the partition function algorithm (McCaskill 1990) are investigated in detail. The pair correlation of free energies as a function of the Hamming distance is used as a measure for the ruggedness of the landscape. The calculation of the partition function contains information about the entire ensemble of secondary structures as a function of temperature and opens the door to all quantities of thermodynamic interest, in contrast with the conventional minimal free energy approach. A metric distance of structure ensembles is introduced and pair correlations at the level of the structures themselves are computed. Just as with landscapes based on most stable secondary structure prediction, the landscapes defined on the full biophysical GCAU alphabet are much smoother than the landscapes restricted to pure GC sequences and the correlation lengths are almost constant fractions of the chain lengths. Correlation functions for multi-structure landscapes exhibit an increased correlation length, especially near the melting temperature. However, the main effect on evolution is rather an effective increase in sampling for finite populations where each sequence explores multiple structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205808
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  • 6
    Electronic Resource
    Electronic Resource
    Algorithm independent properties of RNA secondary structure predictions (1996)
    Springer
    European biophysics journal 25 (1996), S. 115-130 
    Details
    ISSN: 1432-1017
    Keywords: Key words Kinetic folding ; Minimun free energy structures ; RNA secondary structures ; Sequence structure relations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Algorithms predicting RNA secondary structures based on different folding criteria – minimum free energies (mfe), kinetic folding (kin), maximum matching (mm) – and different parameter sets are studied systematically. Two base pairing alphabets were used: the binary GC and the natural four-letter AUGC alphabet. Computed structures and free energies depend strongly on both the algorithm and the parameter set. Statistical properties, such as mean number of base pairs, mean numbers of stacks, mean loop sizes, etc., are much less sensitive to the choice of parameter set and even of algorithm. Some features of RNA secondary structures, such as structure correlation functions, shape space covering and neutral networks, seem to depend only on the base pairing logic (GC or AUGC alphabet).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002490050023
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  • 7
    Electronic Resource
    Electronic Resource
    Coyness, philandering and stable strategies
    Amsterdam : Elsevier
    Animal Behaviour 29 (1981), S. 186-192 
    Details
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0003-3472(81)80165-0
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    The thermochemistry of lithium silicates in view of their use as breeder materials
    Amsterdam : Elsevier
    Fusion Engineering and Design 8 (1989), S. 393-397 
    Details
    ISSN: 0920-3796
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0920-3796(89)80138-3
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  • 9
    Electronic Resource
    Electronic Resource
    Coyness, philandering and stable strategies
    Amsterdam : Elsevier
    Animal Behaviour 29 (1981), S. 186-192 
    Details
    ISSN: 0003-3472
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0003-3472(81)80165-0
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Towards a dynamics of social behaviour: Strategic and genetic models for the evolution of animal conflicts
    Amsterdam : Elsevier
    Journal of Social and Biological Systems 8 (1985), S. 255-277 
    Details
    ISSN: 0140-1750
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0140-1750(85)90070-3
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