Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Secretory phospholipase A2 does not appear to be associated with phenotypic variation in familial adenomatous polyposis (1996)
    Springer
    Human genetics 〈Berlin〉 98 (1996), S. 386-390 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Recent studies in mice have provided strong evidence for a modifier gene that is capable of effecting the expression of the mouse equivalent of familial adenomatous polyposis (FAP). A candidate gene has been proposed, namely secretory phospholipase A2 (sPLA2). Increased tumor number in mice was correlated with low levels of sPLA2 expression and the presence of truncating mutations within the sPLA2 gene. In an attempt to determine whether any genetic alterations in the sPLA2 gene were associated with the expression of FAP in man, we investigated the genetic structure of sPLA2 in 97 polyposis coli patients presenting with various disease phenotypes, and its expression in 8 FAP patients displaying markedly different disease characteristics. In the current study no inactivating mutations in the sPLA2 gene were identified, suggesting that human sPLA2 is not associated with phenotypic variation in FAP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050226
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Identification of a modifier gene locus on chromosome 1p35-36 in familial adenomatous polyposis (1997)
    Springer
    Human genetics 〈Berlin〉 99 (1997), S. 653-657 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Phenotypic variability based on nonallelic heterogeneity is a characteristic feature of the dominantly inherited disease, familial adenomatous polyposis (FAP). A modifying locus, called Mom-1, which strongly influences disease expression has been mapped in the mouse model of FAP to the region of murine chromosome 4, which has synteny to human chromosome 1p35-36. In the present study, this chromosomal region was investigated by using 14 microsatellite markers within a large FAP kindred in which patients harbor the same germ-line mutation but show markedly different disease characteristics. The linkage program MLINK was used to determine whether any correlation exists between these markers and the development of extracolonic symptoms in polyposis coli patients. Depending on the mode of inheritance of the affected locus, a maximum lod score was observed for markers D1S211 and D1S197, reaching 2.08 and 1.77, respectively. The observed values obtained within one large FAP family are supportive of a phenotype-modifying locus within this chromosomal region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050423
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    BING-1: a tin–oxalate–sodium–fluoride framework, Na4Sn4(C2O4)3F6 (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. m111-m113 
    Details
    ISSN: 1600-5368
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: BING-1 [tetrasodium tetratin tris(oxalate) hexafluoride] was synthesized solvothermally at 423 K and crystallized in the triclinic system, with the P\overline 1 space group. The asymmetric unit consists of two types of tin(II) centres, connected by oxalate groups. The Sn atoms are also bonded to fluoride ions, which bond the tin oxalate layers together via interlayer Na atoms, to define a three-dimensional framework.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S1600536801002409
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    BING-2: a layered tin–oxalate potassium fluoride, KSn(C2O4)F (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. i49-i51 
    Details
    ISSN: 1600-5368
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The title compound, KSn(C2O4)F, is a two-dimensional material related to our previously reported three-dimensional framework, Na4Sn4(C2O4)3F6. Both are alkali-metal tin–oxalate materials, but here the compound is layered and has potassium in place of sodium. The material was synthesized solvothermally at 423 K and crystallized in the monoclinic space group P21/c. The structure consists of potassium fluoride layers in the bc plane, which are sandwiched on both sides by tin–oxalate chains that extend along the c axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S1600536801008959
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Interactions between naturalised exotic salmonids and reintroduced Atlantic salmon in a Lake Ontario tributary (2005)
    Oxford, UK : Munksgaard International Publishers
    Ecology of freshwater fish 14 (2005), S. 0 
    Details
    ISSN: 1600-0633
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract –  Atlantic salmon (Salmo salar) was once native to Lake Ontario, however, its numbers rapidly declined following colonisation by Europeans and the species was extirpated by 1896. Government agencies surrounding Lake Ontario are currently undertaking a variety of studies to assess the feasibility of reintroducing Atlantic salmon. We released hatchery-reared adult Atlantic salmon into a Lake Ontario tributary to examine spawning interactions between this species and fall-spawning exotic salmonids found in the same stream. Chinook salmon, coho salmon and brown trout were observed interacting with spawning Atlantic salmon in nearly one-quarter of our observation bouts, with chinook salmon interacting most frequently. Whereas a previous investigation found that chinook salmon caused elevated agonistic behaviour and general activity by spawning Atlantic salmon, the present study found that interspecific courtship was the most common form of exotic interaction with spawning Atlantic salmon. In particular, we observed precocial male Chinook salmon courting female Atlantic salmon and defending the female against approach by male Atlantic salmon. We discuss the potential implications of these interactions on the Lake Ontario Atlantic salmon reintroduction programme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0633.2005.00115.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Sensory drive and nuptial colour loss in the three-spined stickleback (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 59 (2001), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Three-spined sticklebacks Gasterosteus aculeatus, from the Chehalis River drainage. Washington, U.S.A., that have lost the mosaic nuptial signal were more likely to be found in tannin stained sub-drainages whereas those expressing the mosaic nuptial signal were more likely to be found in sub-drainages that were not tannin stained. This result is consistent with the sensory drive model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2001.tb00217.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The Polymerization of Cyclopropane (1952)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 56 (1952), S. 156-160 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j150493a031
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Alosetron repeat dose pharmacokinetics, effects on enzyme activities, and influence of demographic factors (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To assess the pharmacokinetics of alosetron, its effect on in vivo enzyme activities, and influence of demographic factors during repeated dosing.Methods : Thirty healthy men and women received 1 mg oral alosetron twice-daily for 29.5 days and a single oral dose of a metabolic probe cocktail before and on the last day of alosetron dosing. Serum alosetron concentrations were measured on days 1, 8, 15, 22 and 29. Probe-substrate and metabolite concentrations were measured after each cocktail dose.Results : Alosetron accumulation in serum was negligible. Exposure to alosetron did not alter probe-metabolite/substrate ratios associated with CYP2C19, 2E1, 2C9, or 3A4 activity, but modestly decreased those associated with CYP1A2 and N-acetyltransferase activity. Systemic exposure to alosetron was higher in women, positively correlated with age and body mass index, and negatively correlated with CYP1A2 activity. Incidence of constipation was higher in women, but not associated with alosetron concentration.Conclusions : Single dose data can reliably predict the pharmacokinetics of alosetron after repeated doses. Alosetron exhibits limited potential for inhibition of cytochrome P450-mediated metabolism. Interindividual differences in alosetron pharmacokinetics associated with demographic factors may be related to strong dependence on metabolism by CYP1A2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02031.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Effects of exotic salmonids on juvenile Atlantic salmon behaviour (2005)
    Oxford, UK : Munksgaard International Publishers
    Ecology of freshwater fish 14 (2005), S. 0 
    Details
    ISSN: 1600-0633
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract –  We examined the effects of two salmonid species, chinook salmon (Oncorhynchus tschwaytscha) and brown trout (Salmo trutta), both exotic species to Lake Ontario, on behaviour and foraging success of juvenile Atlantic salmon (S. salar), a native species to Lake Ontario, in an artificial stream. We found that both exotic species have effects on Atlantic salmon behaviour, but that neither had an effect on foraging success. These results may explain why the Atlantic salmon re-introduction programme in Lake Ontario has had little success, as more than 3 million exotic salmonids are released in Lake Ontario streams annually.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0633.2005.00099.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Assortative mating between adjacent populations of threespine stickleback (Gasterosteus aculeatus) (2004)
    Oxford, UK : Munksgaard International Publishers
    Ecology of freshwater fish 13 (2004), S. 0 
    Details
    ISSN: 1600-0633
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract –  The idea that sexual selection can lead to rapid evolution of premating isolation among independent populations (speciation) has been controversial, but is rapidly gaining acceptance among many evolutionary biologists as empirical examples accumulate. A survey of male signals and female preferences (mate recognition systems, MRSs) across the contact zone between divergent populations of threespine stickleback (Gasterosteus aculeatus) in Conner Creek, WA, revealed a spatial pattern of MRSs that is consistent with speciation via sexual selection. Females from locations that possessed melanic males preferred melanic males whereas females from populations possessing typical mosaic males (red chin, blue iris, and blue-green dorsum) preferred mosaic males. I argue that sensory drive sexual selection, acting through geographically varying spectral properties, is responsible for the observed population differences and premating isolation between the adjacent populations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6691.2004.00037.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...