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  • 1
    Electronic Resource
    Electronic Resource
    The effect of ranitidine and cimetidine on imipramine disposition (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 285-290 
    Details
    ISSN: 1432-1041
    Keywords: imipramine ; ranitidine ; cimetidine ; pharmacokinetics ; metabolism ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic characteristics of imipramine were studied after a single, oral, 100 mg dose was taken by 12 healthy male subjects following 3 days of pretreatment with placebo, cimetidine (300 mg every 6 h), and ranitidine (150 mg every 12 h) in a randomized, double blind, crossover trial. After each imipramine dose plasma samples were collected for 72 h and assayed for imipramine, desipramine, 2-hydroxyimipramine and 2-hydroxydesipramine by HPLC. Cimetidine preadministration statistically prolonged imipramine t1/2 compared to ranitidine (22.7 vs. 13.0 h) or placebo (10.8 h). Mean imipramine area under the curve (AUC) following cimetidine pretreatment was more than double that following placebo (2.633 vs. 0.966 µg·h·ml−1) or ranitidine (1.14 µg·h·ml−1) pretreatment. Imipramine apparent oral clearance was reduced in all 12 subjects after cimetidine. Compared to ranitidine or placebo, cimetidine pretreatment was associated with an increased imipramine/desipramine AUC ratio, suggesting cimetidine-induced impairment of demethylation of imipramine. Ranitidine was not observed to alter imipramine pharmacokinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00981125
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of pneumococcal vaccine on the disposition of theophylline (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 505-507 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; Streptococcus pneumoniae ; Bordetella pertussis ; pneumococcal vaccine ; pharmacokinetics ; chronic obstructive airway disease (COAD)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Pneumococcal vaccine is frequently given to chronic obstructive airway disease patients who are maintained on theophylline therapy. Several studies demonstrating the effect of viral and bacterial vaccines on drug metabolism prompted our evaluation of the effect of pneumococcal vaccine on theophylline pharmacokinetics. Six healthy volunteers, acting as their own controls, received 250 mg of theophylline every 8h for 12 days. Plasma area under the concentration-time curves (AUC) were measured on Days 4, 6, and 12. On Day 5 pneumococcal vaccine (0.5 ml) was given intramuscularly. No significant difference in elimination rate constant, AUC, or apparent oral clearance of theophylline was found at one or seven days after vaccine administration. These results indicate that intramuscular pneumococcal vaccine does not alter the pharmacokinetics of theophylline during chronic oral administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01046710
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Acute effects of short-term subcutaneous terbutaline on theophylline disposition (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 191-193 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; terbutaline ; pharmacokinetics ; asthma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Theophylline and subcutaneous terbutaline are frequently used concurrently in the management of acute asthma. Recent evidence demonstrating a reduction in theophylline serum concentrations during concomitant oral terbutaline therapy prompted our evaluation of subcutaneous terbutaline's effect on theophylline pharmacokinetics. Using a randomized, placebo controlled, crossover design, the disposition of a single oral theophylline dose (7 mg/kg) was studied in eight healthy, adult males before and after repeated subcutaneous administration of terbutaline (0.25 mg). Two-way analysis of variance revealed no significant difference in elimination rate constant (ke), area under the concentration-time curve (AUC), or apparent oral clearance (CL/F) of theophylline following terbutaline administration. These results indicate that subcutaneous administration of terbutaline does not alter the pharmacokinetics of single, oral doses of theophylline in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542194
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  • 4
    Electronic Resource
    Electronic Resource
    Immunogold localisation of ubiquitin-protein conjugates in primary (azurophilic) granules of polymorphonuclear neutrophils
    Amsterdam : Elsevier
    FEBS Letters 279 (1991), S. 175-178 
    Details
    ISSN: 0014-5793
    Keywords: Azurophilic granule ; Lysosome ; Polymorphonuclear neutrophil ; Ubiquitin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(91)80142-P
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  • 5
    Electronic Resource
    Electronic Resource
    Electron microscopic and voltammetric analysis of carbon fibre electrode pretreatments (1992)
    Springer
    Journal of materials science 3 (1992), S. 418-425 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The comparison between the differential pulse voltammetric capability of untreated or treated 12 µm or 30 µm diameter carbon fibre electrodes (CFE) to detect electroactive compoundsin vitro has been analysed. Their affinity for ascorbic acid (AA), catechols (dopamine (DA); 3,4-dihydroxyphenylacetic acid (DOPAC)), indoles (serotonin (5HT); 5-hydroxyindoleacetic acid (5HIAA)) and uric acid (UA) has been quantified. It appeared that only the 12 µm CFE, when electrically pretreated, can selectively and simultaneously detect the oxidation of AA, catechols and indoles, while the electrically pretreated 30 µm CFE are specifically sensitive to the indoles. However, both electrodes displayed highest sensitivity for serotonin. To avoid the detection of acids and selectively monitor the oxidation of DA and 5HT the 12 µm CFE and the 30 µm CFE were chemically (chromic acid) and electrically pretreated then electrically coated with Nafion. However, the 30 µm CFE alone selectively measured these compoundsin vitro as the 12 µm CFE did not accept the coat of Nafion. Using transmission electron microscopy (TEM) and scanning electron microscopy (SEM), we have investigated the effect of electrical and/or chemical pretreatments on the structural characteristics of the CFE. It appeared that both pretreatments increased the surface area of the carbon fibres by pitting, roughening and fracturing the carbon. Holes were also observed on the surface of the 30 µm dia. carbon fibres following the electrical pretreatment. The possibility of a correlation between these modifications and the pretreatment-induced voltammetric high sensitivity of the CFE is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00701238
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Epithelial restitution in the large intestine of the rat following insult with bile salts (1988)
    Springer
    Virchows Archiv 414 (1988), S. 77-81 
    Details
    ISSN: 1432-2307
    Keywords: Epithelium ; Intestine ; Desquamation ; Restitution ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In situ loops of large bowel of anaesthetised rats were used to observe epithelial restitution following surface desquamation using solutions of bile salts. The treatment induced complete surface desquamation but no disruption of the basal lamina. There was evidence of, cell migration at 30 min, and a complete surface epithelium two h post treatment. Neither a continuous contact between migrating cells and the basal lamina, nor a complete covering of secreted mucus, appeared necessary for epithelial restitution to occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00749741
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