ISSN:
0951-4198
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Physics
Notes:
Stereochemistry study has always been a very important subject, but the determination of chirality has become potentially possible with the emergence of chemical ionization. In this study, mass spectrometry and tandem mass spectrometry (MS/MS) were used as a tool for distinguishing the isomers of (+) and (-) isopinocampheols and (+) and (-) menthols by ion/molecule reaction in the gas phase using two different chiral gases, G. The reactive plasma is made up of the ion GH+. Interactions between the plasma and the isomer M of (+) and (-) isopinocampheols and (+) and (-) menthols lead to the formation of the ions [M-M2O+H]+, [M-H2O+GH]+, [M+GH]+ and [2M+H]+. In mass spectrometric analysis, their relative intensities differ because of the absolute configuration of M. In MS/MS the relative intensities of the daughter ions of [M-H2O+GH]+ ions enable a positive determination of (+) and (-) isomers. The susbtitution ion [M-H2O+GH]+ arises via an SN2 pathway that is regioselective and sterospecific.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/rcm.1290081107
Permalink
