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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 108 (1991), S. 70-77 
    ISSN: 0942-0940
    Keywords: Foramen magnum ; clivus ; meningioma ; chordoma ; lateral approach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lesions ventral to the neuraxis at the craniocervical junction can pose a significant management problem because of their strategic location. Conventional posterolateral approaches sometimes may not permit adequate visualization of the entire base of the tumor without significant manipulation of the brain stem and spinal cord. The anterior transoral and extrapharyngeal approaches are alternate ways of exposing this region without neural retraction. However, these approaches do not provide adequate exposure of the lateral margins of the tumour, there is no control of the vertebral arteries and cranial nerves and the tumor—brain stem interface is not seen till the end of the operation. A lateral approach is described in this report which involves additional bone removal in the region of the mastoid process and the articular pillars in order to provide a true lateral perspective for the removal of these tumors. The advantages include excellent definition of the interface between the tumor and cord/brain stem without manipulation of the neuraxis, control of the ipsilateral vertrebral artery and caudal cranial nerves, ability to remove the intra- and extradural portions of the tumor in one operation and the ability to perform an immediate bony fusion if necessary. The application of this approach in the management of 9 patients with a variety of intra- and extradural lesions at the clivus and foramen magnum is discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 81 (1990), S. 18-24 
    ISSN: 1432-1106
    Keywords: Facial motonucleus ; Hemifacial spasm ; Kindling ; Animal model of hemifacial spasm ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On the basis of results of electrophysiological studies in patients undergoing microvascular decompression (MVD) operations to relieve hemifacial spasm (HFS), we have postulated that the abnormal muscle response characteristically found in patients with HFS is the result of irritation of the facial nerve by the blood vessel that is compressing the facial nerve near its exit from the brainstem in these patients. This abnormal muscle response is seen when one branch of the facial nerve is electrically stimulated and recordings are made from muscles that are innervated by other branches of the facial nerve. We further hypothesized that the facial nucleus is hyperactive in patients with HFS and that the spasm and the abnormal muscle response are results of a phenomenon known as “kindling”. These hypotheses are supported by recent studies showing that chronic electrical stimulation of the facial nerve trunk in rats near the brainstem results in an abnormal muscle response that is similar to that seen in patients with HFS. In this paper, we present the results of recording from the facial motonucleus in rats that had been subjected to repeated electrical stimulation of the facial nerve. The results indicate that the abnormal muscle response in these rats was caused by changes in the function of the facial motonucleus. We interpret these results as showing that the physiological abnormalities that give rise to the signs of HFS in man are located in the facial motonucleus, and that the changes in the function of the nucleus are produced by chronic antidromic neural activity resulting from close contact between a blood vessel and the facial nerve.
    Type of Medium: Electronic Resource
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