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  • 1
    Electronic Resource
    Electronic Resource
    Receptor-Mediated Inotropic Effect in Heart (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 639 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb17328.x
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  • 2
    Electronic Resource
    Electronic Resource
    Ouabain stimulation of noradrenaline transport in guinea pig heart (1980)
    [s.l.] : Nature Publishing Group
    Nature 286 (1980), S. 817-819 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] There is increasing evidence that low doses of cardiac glycosides increase the contractility of the myocardium and stimulate the active transmembranous transport of monovalent cations15'18. Such a conclusion has been vigorously challenged by Michael and co-workers19'20. It is possible that the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/286817a0
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  • 3
    Electronic Resource
    Electronic Resource
    Alterations in β-adrenergic receptor binding during ethanol withdrawal (1978)
    [s.l.] : Nature Publishing Group
    Nature 276 (1978), S. 407-409 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 Effect of chronic ethanol treatment on specific binding of 3H-DHA to b-adrenergic receptors in brain and heart particulate fractions Time after termination of ethanol Brain Heart treatment Ethanol- Ethanol- (h) Control treated Control treated 0 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/276407a0
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  • 4
    Electronic Resource
    Electronic Resource
    Presynaptic muscarinic cholinergic receptors (1978)
    [s.l.] : Nature Publishing Group
    Nature 272 (1978), S. 276-278 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The sympathetic nerve endings of peripheral organs may be selectively destroyed by the intravenous administration of 6-hydroxydopamine8'9. A predominant localisation of [3H]-ouabain binding sites in the sympathetic nerve endings of cat heart was demonstrated by measuring specific [?]-ouabain ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/272276a0
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  • 5
    Electronic Resource
    Electronic Resource
    Amphetamine induces β-adrenergic receptor supersensitivity (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 380-381 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Effect of chronic administration of ^/-amphetamine on specific binding of 3H-dihydroalprenolol. The drug was administered intraperitoneally at a dose of 10 mg per kg daily for a period of six weeks. The rats were killed at the indicated times after drug administration by decapitation and the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/271380a0
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  • 6
    Electronic Resource
    Electronic Resource
    Extracellular heparin inhibits Ca2+ transients and contraction in mammalian cardiac myocytes (1995)
    Springer
    Pflügers Archiv 431 (1995), S. 84-90 
    Details
    ISSN: 1432-2013
    Keywords: Cardiac muscle ; Calcium transients ; Heparin ; Calcium channels ; Extracellular matrix ; Glycosaminoglycans ; Dihydropyridines ; Cardiomyocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of heparin on Ca2+ transients and cell shortening was studied in isolated cardiac myocytes from rat and guinea-pig ventricles. Ca2+ signals were measured with the fluorescent indicator fura-2. Heparin reversibly decreased Ca2+ transients and cell shortening in a dose-dependent manner. Half and complete blockade were obtained with 50 μg/ml and 200 μg/ml heparin, respectively. The dihydropyridine agonist BAY K 8644 (50 nM) antagonized the effects of heparin. However, Ca2+ release elicited by caffeine (10 mM) was not affected by heparin. The actions of heparin were also studied in multicellular preparations. In papillary muscle, heparin (5 mg/ml) reversibly reduced the amplitude of the plateau of the action potential and the associated peak tension. BAY K 8644 (500 nM) also antagonized these effects. It is proposed that heparin interacts with dihydropyridine-sensitive Ca2+ channels to cause a decrease of Ca2+ transients and contractility in heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374380
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  • 7
    Electronic Resource
    Electronic Resource
    Modulation of cytosolic free calcium concentration by α1-adrenoceptors in rat atrial cells (1992)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 346 (1992), S. 88-93 
    Details
    ISSN: 1432-1912
    Keywords: Intracellular Ca2+ concentration ; Fura-2 ; Ca2+ current ; Phenylephrine ; Isoprenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of α1-adrenoceptor stimulation by phenylephrine (PE) and β-adrenoceptor stimulation by isoprenaline (ISO) on Ca2+ current (ICa) and free intracellular Ca2+ concentration ([Ca2+]i) were studied in isolated atrial myocytes from rat hearts. PE did not significantly affect the magnitude of ICa, whereas large increases of peak ICa were observed in response to ISO. In electrically driven cells, PE evoked a concentration-dependent, gradual increase in diastolic [Ca2+]i and, initially, an increase in the height of peak [Ca2+]i transients. When the diastolic [Ca2+]i was increased to a greater extent, the amplitude of [Ca2+]i transients was decreased. Simultaneous measurements of [Ca2+]i and membrane potential showed that the increase in diastolic [Ca2+]i was associated with a depolarization of the membrane, and the greater amplitude of [Ca2+]i transients with a prolongation of the action potential (AP). The PE-induced increase in diastolic [Ca2+]i was eliminated when the cells were voltage-clamped at the original resting membrane potential (RP); under these conditions, an increase in [Ca2+]i transients was observed in response to PE. ISO usually caused larger increases in the amplitude of [Ca2+]i transients with only minor changes in diastolic [Ca2+]i. These results suggest that PE and ISO increase the amplitude of [Ca2+]i transients in rat atrium in different ways. The increase in [Ca2+]i transients in response to β-adrenoceptor stimulation is commonly thought to be mediated by a greater conductance of voltage-dependent Ca2+ channels causing a greater Ca2+ influx and a release of more Ca2+ from the sarcoplasmic reticulum during the AP. The increase in diastolic [Ca2+]i in response to PE is probably a consequence of the depolarization of the membrane, possibly involving the voltage-dependent Na+-Ca2+ exchange mechanism. The increase in the amplitude of the [Ca2+]i transients in response to PE may be ascribed both to the initial increase in diastolic [Ca2+]i and the prolongation of the AP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167576
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  • 8
    Electronic Resource
    Electronic Resource
    IR study of chlorination of alumina employing mixtures of gaseous chlorine and carbon monoxideDedicated to Professor Dr.-Ing. Hanns Hofmann on the occasion of his 65th birthday (1989)
    Weinheim : Wiley-Blackwell
    Chemical Engineering & Technology - CET 12 (1989), S. 27-32 
    Details
    ISSN: 0930-7516
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The chlorination of an alumina with BET surface area of 100 m2/g has been studied in situ by transmission IR measurements at about 670 K. The chlorinating gases consisting of Cl2 and CO were employed individually and in equimolar proportion. The IR results do not reveal the presence of a phosgene surface species which could support the only mechanism proposed so far to explain the chlorination. A detailed alternative reaction mechanism is suggested for the high temperature chlorination reaction, taking into account the IR results, together with the known electron donor-acceptor properties of the activated alumina and the reaction gases: Cl2 molecules accept electrons from oxide ions with a lower coordination number on the alumina surface, leading to the formation of Cl-and Oad. While Cl- yields AlCl3, Oad reacts further with CO producing CO2.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ceat.270120106
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